Case/ Sex (F or M)	Age	CP	etiology	HE	Portal HTN º	Alb (g/dl)	PT %	Bili mg/dl	Serum* ammonia	Mn** (blood/CSF)	MRI
1) F	74	B	OH	I	no	2,9	70	2,2	31	18/3,3	+
2) F	62	C	Cryptog	II-III	yes	2,4	65	1,8	70	17	++
3) F	82	A	OH	I	no	3,8	72	1,5	6	2,1	+
4) M	61	B	OH	I	no	3,1	55	1,7	14	14	++
5) M	62	C	OH	II-III	Yes	3,3	40	2,5	200	6,2	+
6) M	67	C	HCV	II	Yes	3,1	40	2,4	200	21	++
7) F	51	B	Cryptog	I-II	Yes	4,0	65	1,2	270	26	+++
8) M	67	B	Cryptog	I	Yes	3,0	70	2,1	97	14/2,9	++
9) M	54	B	OH	I-II	Yes	3,0	50	1,2	210	0,3	+
10) M	40	B	PBC	II-III	Yes	3,2	55	1,8	140	16	++
11) F	45	C	Wilson	II	Yes	2,7	45	2,5	90	16	++
12) M	53	B	OH	I-II	no	3,0	50	2,2	92	1,4	+++

* Normal range < 30 ug/ml ** Normal range; serum: < 0.06ug/lt; CSF: 0.22 to 0.72 ug/dl. CSF= cerebral spinal fluid; CP= Child Pugh; Alb= albumin; PT= prothrombin time; OH= ethanol; HCV= hepatitis C virus; HE=hepatic encephalopathy (I to IV grades of West Heaven scale). PBC=primary biliar cholangitis. º Portal HTN=portal hypertension, considered in case of oesophago-gastric varices, splenomegaly and/or ascitis. MRI imaging: mild, moderate and severe changes of intensity in basal ganglia (+ to +++).
Table 1: clinical features, laboratory and radiological findings

Score Child-Pugh	Nº of patients	Range of blood Mn levels (ug/l)* / mean
A	1	2.1
B	7	0.3 – 26 / 8.4
C	4	6.2 – 16 / 15.1

Tables at a glance

Figures at a glance