Tables at a glance

Table 1

Table 2

Table 3

Table 4

Table 5

Figures at a glance

Comments

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Figure 2

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Figure 5

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Figure 9

Table 1

Author	Count	Institution	Author	Co-count	Total link strength	Institution
Kanneganti TD	25	St. Jude Children's Research Hospital	Malireddi RKS	65	2992	St. Jude Children's Research Hospital
Malireddi RKS	12	St. Jude Children's Research Hospital	Newton K	56	2860	Genentech
Karki R	10	St. Jude Children's Research Hospital	Kayagaki N	44	2399	Genentech
Green Dr	8	St. Jude Children's Research Hospital	Shi JJ	43	2108	Institute Of Chinese Medical Sciences
Linkermann A	8	University Hospital Carl Gustav Carus At Technische Universität Dresden	Gurung P	40	1941	St. Jude Children's Research Hospital
Vogel P	8	St. Jude Children's Research Hospital	Man SM	38	1758	St. Jude Children's Research Hospital
Zheng M	8	St. Jude Children's Research Hospital	Karki R	36	1649	St. Jude Children's Research Hospital
Kesavardhana S	7	St. Jude Children's Research Hospital	Dondelinger Y	31	1563	Vib Inflammation Research Center
Place De	7	St. Jude Children's Research Hospital	Kesavardhana S	30	1478	St. Jude Children's Research Hospital
Zhang J	7	Eye & Ent Hosp	Galluzzi L	26	1449	Weill Cornell Medical College

Table 1: Analysis of author and co cited author

Table 2

Rank	Country	Count	Percentage	Co-Country	Count	Percentage	Degree	Affiliations	Count	Percentage
1	China	130	34.9%	Usa	22	34.4%	7	St Jude Children S Research Hospital	34	9.1%
2	USA	126	33.8%	China	17	26.6%	4	League Of European Research Universities Leru	22	5.9%
3	Germany	38	10.2%	Germany	6	9.4%	4	Central South University	17	4.5%
4	Australia	27	7.2%	Australia	4	6.3%	5	Institute National De La Sante Et De La Recherche Medicale Inserm	16	4.3%
5	France	20	5.3%	Belgium	2	3.1%	2	University Of Melbourne	15	4.0%
6	Japan	19	5.1%	Greece	1	1.6%	3	Chinese Academy Of Sciences	14	3.7%
7	England	17	4.5%	Pakistan	1	1.6%	2	Udice French Research Universities	12	3.2%
8	Spain	12	3.2%	Ukraine	1	1.6%	2	Walter Eliza Hall Institute	12	3.2%
9	Belgium	11	2.9%	Hungary	1	1.6%	2	Flanders Institute For Biotechnology Vib	9	2.4%
10	India	10	2.6%	France	1	1.6%	1	Ghent University	9	2.4%

Table 2: Top 10 countries, co-cited countries and institutions analysis

Table 3

Journal	Count	IF	JCR	Journal	Citation	IF	JCR
Cell Death and Differentiation	14	12.067	Q1	Nature	440	69.504	Q1
Cell Death & Disease	14	9.685	Q1	Cell	285	66.85	Q1
Frontiers in Immunology	13	8.786	Q1	Proceedings Of the National	240	12.779	Q1
International Journal of Molecular Sciences	11	6.208	Q2	Cell Death and Differentiation	178	12.067	Q1
Frontiers In Cell and Developmental Biology	8	6.081	Q2	International Journal of Radiation Oncology Biology Physics	160	8.013	Q2
Cells	6	7.666	Q1	Science	160	63.714	Q1
Viruses Basel	6	5.818	Q2	Immunity	158	43.474	Q1
Cell	5	66.85	Q1	Immunology	137	7.215	Q2
Cell Death Discovery	5	7.109	Q2	Journal of Experimental Medicine	118	17.579	Q1

Table 3: Analysis of the number of journal articles and co-citations

Table 4

Rank	Title	Authors	Degree	Journal	Publication Year	DOI
1	Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling	Kayagaki N	29	Nature	2015	10.1038/nature15541
2	TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation	Malireddi RKS	26	J Exp Med	2018	10.1084/jem.20171922
3	Pathogen blockade of TAK1 triggers caspase-8 dependent cleavage of Gasdermin D and cell death	Orning P	9	Science	2018	10.1126/science.aau2818
4	Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.	Shi J	31	Nature	2015	10.1038/nature15514
5	ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways.	Kuriakose T	11	Sci Immunol	2016	10.1126/sciimmunol.aag2045
6	Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection	Sarhan J	22	P Natl Acad Sci Usa	2018	10.1073/pnas.1809548115
7	ZBP1 and TAK1: Master Regulators of NLRP3 Inflammasome/Pyroptosis, Apoptosis, and Necroptosis (PAN-optosis).	Malireddi R	21	Front Cell Infect Mi	2019	10.3389/fcimb.2019.00406
8	Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin.	Wang Y	17	Nature	2017	10.1038/nature22393
9	Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense.[13]	Zheng M	16	Cell	2020	10.1016/j.cell.2020.03.040
10	RIPK1 inhibits ZBP1-driven necroptosis during development.	Newton K	20	NATURE	2016	10.1038/nature20559

Table 4: Analysis of TOP 10 cited reference and

Table 5

Rank	Title	Authors	Degree	Journal	Publication Year	DOI
1	Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling	Kayagaki N	29	Nature	2015	10.1038/nature15541
2	TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation	Malireddi RKS	26	J Exp Med	2018	10.1084/jem.20171922
3	Pathogen blockade of TAK1 triggers caspase-8 dependent cleavage of Gasdermin D and cell death	Orning P	9	Science	2018	10.1126/science.aau2818
4	Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.	Shi J	31	Nature	2015	10.1038/nature15514
5	ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways.	Kuriakose T	11	Sci Immunol	2016	10.1126/sciimmunol.aag2045
6	Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection	Sarhan J	22	P Natl Acad Sci Usa	2018	10.1073/pnas.1809548115
7	ZBP1 and TAK1: Master Regulators of NLRP3 Inflammasome/Pyroptosis, Apoptosis, and Necroptosis (PAN-optosis).	Malireddi R	21	Front Cell Infect Mi	2019	10.3389/fcimb.2019.00406
8	Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin.	Wang Y	17	Nature	2017	10.1038/nature22393
9	Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense.[13]	Zheng M	16	Cell	2020	10.1016/j.cell.2020.03.040
10	RIPK1 inhibits ZBP1-driven necroptosis during development.	Newton K	20	NATURE	2016	10.1038/nature20559

Table 5: Analysis of the TOP 10 co-cited references

FIGURE 1

Figure 1: Flowchart of literature selection

FIGURE 2

Figure 2: Analysis of publications and frequency of citations

FIGURE 3

Figure 3: A. Global spatial distribution of the references. B. Country co-occurrence analysis graph. Size of Label is measured by the number of co-occurring articles in to figures

FIGURE 4

Figure 4: A: Institution citation analysis by VOSviewer. B co-institutional analysis by VOSviewer. (Minimum number of documents of an institution > 2)

FIGURE 5

Figure 5: Author co-occurrence analysis of the literature we obtained by VOSviewer. (Minimum number of documents of an author > 1)

FIGURE 6

Figure 6: A: VOSviewer visualization map of keywords density graph. B. The top 12 keywords in keywords occurrence frequency

FIGURE 7

Figure 7: VOSviewer visualization map of keywords clustering analysis related to PANoptosis

FIGURE 8

Figure 8: Top 10 keywords with the strongest citation bursts

FIGURE 9

Figure 9: CiteSpace visualization map of timeline viewer related to PANoptosis