Figure 1: Flowchart of literature selection
Author |
Count |
Institution |
Author |
Co-count |
Total link strength |
Institution |
Kanneganti TD |
25 |
St. Jude Children's Research Hospital |
Malireddi RKS |
65 |
2992 |
St. Jude Children's Research Hospital |
Malireddi RKS |
12 |
St. Jude Children's Research Hospital |
Newton K |
56 |
2860 |
Genentech |
Karki R |
10 |
St. Jude Children's Research Hospital |
Kayagaki N |
44 |
2399 |
Genentech |
Green Dr |
8 |
St. Jude Children's Research Hospital |
Shi JJ |
43 |
2108 |
Institute Of Chinese Medical Sciences |
Linkermann A |
8 |
University Hospital Carl Gustav Carus At |
Gurung P |
40 |
1941 |
St. Jude Children's Research Hospital |
Vogel P |
8 |
St. Jude Children's Research Hospital |
Man SM |
38 |
1758 |
St. Jude Children's Research Hospital |
Zheng M |
8 |
St. Jude Children's Research Hospital |
Karki R |
36 |
1649 |
St. Jude Children's Research Hospital |
Kesavardhana S |
7 |
St. Jude Children's Research Hospital |
Dondelinger Y |
31 |
1563 |
Vib Inflammation Research Center |
Place De |
7 |
St. Jude Children's Research Hospital |
Kesavardhana S |
30 |
1478 |
St. Jude Children's Research Hospital |
Zhang J |
7 |
Eye & Ent Hosp |
Galluzzi L |
26 |
1449 |
Weill Cornell Medical College |
Table 1: Analysis of author and co cited author
Rank |
Country |
Count |
Percentage |
Co-Country |
Count |
Percentage |
Degree |
Affiliations |
Count |
Percentage |
1 |
China |
130 |
34.9% |
Usa |
22 |
34.4% |
7 |
St Jude Children S Research Hospital |
34 |
9.1% |
2 |
USA |
126 |
33.8% |
China |
17 |
26.6% |
4 |
League Of European Research Universities Leru |
22 |
5.9% |
3 |
Germany |
38 |
10.2% |
Germany |
6 |
9.4% |
4 |
Central South University |
17 |
4.5% |
4 |
Australia |
27 |
7.2% |
Australia |
4 |
6.3% |
5 |
Institute National De La Sante Et De La Recherche Medicale Inserm |
16 |
4.3% |
5 |
France |
20 |
5.3% |
Belgium |
2 |
3.1% |
2 |
University Of Melbourne |
15 |
4.0% |
6 |
Japan |
19 |
5.1% |
Greece |
1 |
1.6% |
3 |
Chinese Academy Of Sciences |
14 |
3.7% |
7 |
England |
17 |
4.5% |
Pakistan |
1 |
1.6% |
2 |
Udice French Research Universities |
12 |
3.2% |
8 |
Spain |
12 |
3.2% |
Ukraine |
1 |
1.6% |
2 |
Walter Eliza Hall Institute |
12 |
3.2% |
9 |
Belgium |
11 |
2.9% |
Hungary |
1 |
1.6% |
2 |
Flanders Institute For Biotechnology Vib |
9 |
2.4% |
10 |
India |
10 |
2.6% |
France |
1 |
1.6% |
1 |
Ghent University |
9 |
2.4% |
Table 2: Top 10 countries, co-cited countries and institutions analysis
Journal |
Count |
IF |
JCR |
Journal |
Citation |
IF |
JCR |
Cell Death and Differentiation |
14 |
12.067 |
Q1 |
Nature |
440 |
69.504 |
Q1 |
Cell Death & Disease |
14 |
9.685 |
Q1 |
Cell |
285 |
66.85 |
Q1 |
Frontiers in Immunology |
13 |
8.786 |
Q1 |
Proceedings Of the National |
240 |
12.779 |
Q1 |
International Journal of Molecular Sciences |
11 |
6.208 |
Q2 |
Cell Death and Differentiation |
178 |
12.067 |
Q1 |
Frontiers In Cell and Developmental Biology |
8 |
6.081 |
Q2 |
International Journal of Radiation Oncology Biology Physics |
160 |
8.013 |
Q2 |
Cells |
6 |
7.666 |
Q1 |
Science |
160 |
63.714 |
Q1 |
Viruses Basel |
6 |
5.818 |
Q2 |
Immunity |
158 |
43.474 |
Q1 |
Cell |
5 |
66.85 |
Q1 |
Immunology |
137 |
7.215 |
Q2 |
Cell Death Discovery |
5 |
7.109 |
Q2 |
Journal of Experimental Medicine |
118 |
17.579 |
Q1 |
Table 3: Analysis of the number of journal articles and co-citations
Rank |
Title |
Authors |
Degree |
Journal |
Publication Year |
DOI |
1 |
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling |
Kayagaki N |
29 |
Nature |
2015 |
10.1038/nature15541 |
2 |
TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation |
Malireddi RKS |
26 |
J Exp Med |
2018 |
10.1084/jem.20171922 |
3 |
Pathogen blockade of TAK1 triggers caspase-8 dependent cleavage of Gasdermin D and cell death |
Orning P |
9 |
Science |
2018 |
10.1126/science.aau2818 |
4 |
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. |
Shi J |
31 |
Nature |
2015 |
10.1038/nature15514 |
5 |
ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways. |
Kuriakose T |
11 |
Sci Immunol |
2016 |
10.1126/sciimmunol.aag2045 |
6 |
Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection |
Sarhan J |
22 |
P Natl Acad Sci Usa |
2018 |
10.1073/pnas.1809548115 |
7 |
ZBP1 and TAK1: Master Regulators of NLRP3 Inflammasome/Pyroptosis, Apoptosis, and Necroptosis (PAN-optosis). |
Malireddi R |
21 |
Front Cell Infect Mi |
2019 |
10.3389/fcimb.2019.00406 |
8 |
Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin. |
Wang Y |
17 |
Nature |
2017 |
10.1038/nature22393 |
9 |
Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense.[13] |
Zheng M |
16 |
Cell |
2020 |
10.1016/j.cell.2020.03.040 |
10 |
RIPK1 inhibits ZBP1-driven necroptosis during development. |
Newton K |
20 |
NATURE |
2016 |
10.1038/nature20559 |
Table 4: Analysis of TOP 10 cited reference and
Rank |
Title |
Authors |
Degree |
Journal |
Publication Year |
DOI |
1 |
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling |
Kayagaki N |
29 |
Nature |
2015 |
10.1038/nature15541 |
2 |
TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation |
Malireddi RKS |
26 |
J Exp Med |
2018 |
10.1084/jem.20171922 |
3 |
Pathogen blockade of TAK1 triggers caspase-8 dependent cleavage of Gasdermin D and cell death |
Orning P |
9 |
Science |
2018 |
10.1126/science.aau2818 |
4 |
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. |
Shi J |
31 |
Nature |
2015 |
10.1038/nature15514 |
5 |
ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways. |
Kuriakose T |
11 |
Sci Immunol |
2016 |
10.1126/sciimmunol.aag2045 |
6 |
Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection |
Sarhan J |
22 |
P Natl Acad Sci Usa |
2018 |
10.1073/pnas.1809548115 |
7 |
ZBP1 and TAK1: Master Regulators of NLRP3 Inflammasome/Pyroptosis, Apoptosis, and Necroptosis (PAN-optosis). |
Malireddi R |
21 |
Front Cell Infect Mi |
2019 |
10.3389/fcimb.2019.00406 |
8 |
Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin. |
Wang Y |
17 |
Nature |
2017 |
10.1038/nature22393 |
9 |
Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense.[13] |
Zheng M |
16 |
Cell |
2020 |
10.1016/j.cell.2020.03.040 |
10 |
RIPK1 inhibits ZBP1-driven necroptosis during development. |
Newton K |
20 |
NATURE |
2016 |
10.1038/nature20559 |
Table 5: Analysis of the TOP 10 co-cited references
Figure 1: Flowchart of literature selection
Figure 2: Analysis of publications and frequency of citations
Figure 3: A. Global spatial distribution of the references. B. Country co-occurrence analysis graph. Size of Label is measured by the number of co-occurring articles in to figures
Figure 4: A: Institution citation analysis by VOSviewer. B co-institutional analysis by VOSviewer. (Minimum number of documents of an institution > 2)
Figure 5: Author co-occurrence analysis of the literature we obtained by VOSviewer. (Minimum number of documents of an author > 1)
Figure 6: A: VOSviewer visualization map of keywords density graph. B. The top 12 keywords in keywords occurrence frequency
Figure 7: VOSviewer visualization map of keywords clustering analysis related to PANoptosis
Figure 8: Top 10 keywords with the strongest citation bursts
Figure 9: CiteSpace visualization map of timeline viewer related to PANoptosis
Tables at a glance
Figures at a glance