Table 1

Medical applications	Dog animal model
Retinal studies	(14)
Cataracts	(15)
Retinitis pigmentosoa	(16)
Cancer	(17)
Epilepsy	(18)
Allergic studies	(19)

Table 1

Table 2

Medical applications	Chicken animal model
Aging studies	(25)
Memory evaluation	(26)
Parasitology	(27)
Atherosclerosis	(28)
Reproductive studies	(29)
Infectious disease	(30)
Toxicology	(31)

Table 2

Table 3

Medical applications	Pig animal model
Mouth surgical	(40)
Face surgical	(41)
Orthopedics surgical	(42)
Plastic surgical	(43)

Table 3

Table 4

Medical applications	Guinea pig animal model
Tuberculosis studies	(53)
Syphilis disease	(54)
Cholesterol metabolism	(55)
asthma	(56)
Alzheimer's disease	(57)

Table 4

Table 5

Medical applications	Rat animal model
Feeding studies	(63)
Genetic	(64)
Immunology	(65)
Neurology	(66)
Infectious disease	(67)
Metabolic disease	(68)
Behavioral disease	(69)

Table 5

Table 6

Medical applications	Animal model mice
High blood pressure	(74)
Diabetes	(75)
Cataract	(76)
Obesity	(77)
Epilepsy	(78)
Breathing problems	(79)
Parkinson's disease	(80)

Table 6

Table 7

Medical applications	Animal model rabbit
Atherosclerosis disease	(84)
Immunologic disease	(85)
Osteoporosis	(86)
Eye disease	(87)
Organ surgery	(88)
Pharmacologic studies	(89)
Pregnancy	(90)

Table 7

Table 8

Medical applications	Animal model monkey
Diabetes mellitus	(97)
Autoimmune Encephalitis	(98)
Multiple sclerosis	(99)
Huntington's disease	(100)

Table 8

Table 9

Medical applications	Animal model chimpanzee
Malaria falciparum	(104)
Epithelial cancer	(105)
Alzheimer's disease	(106)
HIV disease	(107)
Hepatitis disease	(108)

Table 9

Table 10

Medical applications	Zebrafish animal model
Biochemical studies	(144)
Molecular biology	(115)
Cellular biology	(116)
Epilepsy and ASD disease	(117)
Genetics studies	(118)

Table 10

Tables at a glance

Table 1

Table 2

Table 3

Table 4

Table 5

Table 6

Table 7

Table 8

Table 9

Table 10

Figures at a glance

Comments

Figure 1

Comments

Figure 2

FIGURE 1

Figure 1: Mouse models of liver cancer. A – Spontaneous model B – Xenograft C – Syngeneic D – Genetically engineered mice

FIGURE 2

Table 1: Summary of animal models of human diseases using the CRISPR gene editing system