Figure 1: Antibiotic Sensitivity Test
Groups |
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Parameters |
Control |
|
Ia |
|
Ib |
|
Ic |
|
Id |
|
Hb (g/dl) |
12.23±0.17* |
14.18±0.03 |
14.60±0.40* |
15.01±0.93* |
15.07±0.20* |
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PCV (%) |
39.14± 1.10* |
45.38± 1.05* |
46.72± 1.00* |
48.03±1.06* |
48.22±1.40* |
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WBC (109/L) |
7.32±0.21* |
10.04±0.77* |
10.20±0.60* |
10.35±0.25* |
10.41±0.10* |
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Lymphocytes(%) |
56.34±1.30* |
58.97±1.15* |
60.04±1.29* |
62.19±1.30* |
61.64±1.18* |
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Eosinophils(%) |
0.11±0.01 |
|
0.25±0.02 |
|
0.28±0.03 |
|
0.20±0.02 |
|
0.38±0.03 |
|
Monocytes (%) |
0.50±0.06 |
0.41±0.01 |
0.43±0.09 |
0.44±0.08 |
0.49±0.06 |
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Basophils (%) |
0.30±0.08 |
0.31±0.01 |
0.33±0.01 |
0.35± 0.03 |
0.30±0.02 |
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MCH (pg) |
3.52±0.10 |
3.56±0.22 |
3.59±0.19 |
4.08±0.10 |
4.10±0.39 |
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MCHC (g/dl) |
0.90±0.03 |
0.92±0.01 |
0.91±0.02 |
0.93±0.01 |
0.93±0.05 |
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ESR (mm/hr) |
5.01±0.16 |
5.09±0.27 |
5.14±0.10 |
5.32±0.89 |
5.10±0.20 |
|
Results are mean and standard deviation of five determinations. Values asterisked are statistically significant against the control (p<0.05).
Table 1 : Acute toxicity studies of haematology of rats given Solanum aethiopicum leaf for 28 days
Concentratio of extract(mg/ml) |
E.coli |
Staphylococcus aureus |
Streptococcus sp |
Klebsiella sp |
|
14.00 |
12.50 |
11.80 |
10.60 |
200 |
12.00 |
10.00 |
9.30 |
8.40 |
100 |
9.00 |
8.00 |
7.20 |
6.80 |
50 |
7.00 |
6.20 |
5.10 |
- |
|
21.00 |
17.00 |
14.50 |
12.80 |
Table 2: Mean diameter zones of inhibition of ethanol leaf extracts against the tested organisms (mm)
Extaracts |
E.coli |
Staphylococcus aureus |
Streptococcus sp |
Klebsiella sp |
|
50 |
50 |
100 |
100 |
|
100 |
100 |
200 |
200 |
Table 3: Minimum inhibitory concentration (MIC) of the test extracts (mg/ml)
|
T. WBC SX103 |
NEX103 |
Lyx103 |
MOX103 |
EOX103 |
After zero time from infection A |
4.60 |
3.05 |
1.17 |
0.37 |
0.00 |
B |
4.30 |
2.79 |
1.07 |
0.34 |
0.00 |
AB |
4.50 |
3.05 |
1.17 |
0.37 |
0.00 |
After 5 days from infection A |
4.60 |
3.05 |
1.17 |
0.37 |
0.00 |
B |
9.70 |
7.96 |
1.02 |
0.72 |
0.00 |
AB |
11.30 |
10.05 |
1.18 |
0.10 |
0.00 |
After 8 days from infection A |
4.60 |
3.05 |
1.17 |
0.37 |
0.00 |
B |
14.40 |
7.13 |
0.61 |
0.69 |
0.00 |
AB |
9.50 |
7.96 |
1.02 |
0.72 |
0.00 |
After 12 days from infection A |
4.60 |
3.05 |
1.17 |
0.37 |
0.00 |
B |
16.30 |
13.84 |
1.32 |
0.94 |
0.00 |
AB |
7.30 |
6.31 |
0.09 |
0.58 |
0.00 |
After 16 days from infection A |
4.60 |
3.05 |
1.17 |
0.37 |
0.00 |
B |
13.60 |
11.85 |
1.63 |
0.21 |
0.00 |
AB |
5.10 |
5.58 |
0.98 |
0.51 |
0.00 |
A = Control; B = Infected mice with E.coli; AB = Infected mice with E.coli and treated with plant extract; TWBCs = total white blood cells; Ne= Neutrophil; Ly = Lymphosite; Mo= Monosite Eo = Eosinophil
Table 4: The effect of Solanum aethiopicum leaf extract on E.coli in vivo
Figure 1: Antibiotic Sensitivity Test
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