Figures at a glance

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FIGURE 1

Figure 1: Body weight of female C57BL/6cenp mice up to 15-16 months of age. Data (n=10) shown are the means±SD. * indicates P< 0.05 compared to young control group (3-4 months of age)

FIGURE 2

Figure 2: Y maze task of female C57BL/6cenp mice up to 15-16 months of age. A) Number of entries to each maze’s arm. B) Percentage of alternation. Data (n=10) shown are the means ±SD. * indicates P< 0.05 compared to young control group (3-4 months of age)

FIGURE 3

Figure 3: Morris water maze task of female C57BL/6cenp mice up to 15-16 months of age. A) Change in latency over time in young animals. B) Change in latency over time in aged animals. C) Percentage of time in each quadrant. Data (n=10) shown are the means±SD. * indicates P< 0.05 compared to young control group (3-4 months of age). + indicates P< 0.05 compared to day 2 of training. o indicates P< 0.05 compared to day 3 of training

FIGURE 4

Figure 4: Escape latency in female C57BL/6cenp mice up to 15-16 months of age. (A) Passive avoidance test. Data (n=10) shown are the means±SD. * indicates P< 0.05 compared to young control group (3-4 months of age)

FIGURE 5

Figure 5: Hematological parameters and glucose concentration of female C57BL/6cenp mice up to 15-16 months of age. (A) Lymphocytes. (B) Nuclear polymorphs. (C) Glucose. Data (n=10) shown are the means±SD. * indicates P< 0.05 compared to young control group (4-5 months of age)

FIGURE 6

Figure 6: Weight of the organs relative to the body weight of female C57BL/6cenp mice up to 15-16 months of age. (A) Brain weight. (B) Thymus weight. (C) Spleen weight. (D) Lungs weight. (E) Liver weight. Data shown are the means±SD. * indicates P< 0.05 compared to young control group (3-4 months of age)

FIGURE 7

Figure 7: Damages presented in lungs of female C57BL/6cenp mice up to 15-16 months of age. (A) Minimal infiltration of lymphocytes in lungs of young control group (3-4 months of age). (B) Non-affected regions in lungs of aged mice (C) Thickening of the alveolar septa and lymphocytic infiltration in aged mice. HE 40X

FIGURE 8

Figure 8: Damages presented in liver of female C57BL/6cenp mice up to 15-16 months of age. (A) Normal morphology of the liver of young control animals. HE 40X. (B) Perivascular lymphocytic infiltration in aged mice. HE 40X. (C) Macro focal and micro vesicular lipidosis in aged mice. HE 40X

FIGURE 9

Figure 9: Normal brain of female C57BL/6cenp mice up to 15-16 months of age. (A) Cerebellum of mice from the young, healthy control group. (B) Cerebellum of the aged, healthy group. HE40X