S no	Mechanical Property	Clinical Relevance	Design objective	Design option
1	Pushability: ability to exert longitudinal force from the proximal end to distal end of the shaft	Allows the physician to easily push the device to the target treatment site	Maximize the pushability of the catheter	Maximize areal moment of inertia/cross sectional area tensile stiffness
2	Torque transmission: ability to transmit proximal end input torque to distal end output torque	Allows for rotation of the implant in the intended orientation with respect to the patient anatomy	Maximize the torque transmission with minimal inter-shaft frictional loss	Maximize polar moment of inertia torsional stiffness
3	Trackability: ability to flex with application of minimal bending force	Allows the catheter to bend and conform to the patient’s anatomy without causing traumatic vascular damage	Maximize the bendability	Minimize cross sectional area/moment of inertia bending stiffness
4	Kink Radius- ability to bend around corners without distortion of cross-sectional shape of the catheter	Allows for easier delivery of implants and ancillary devices like guidewires through the catheter lumen to the target treatment site	Retain the cross-sectional shape of the catheter with minimal shape distortion	Maximize cross sectional area/ areal moment of inertia Minimize bending stiffness

Table 1 : Catheter Mechanical Properties, their clinical relevance and design options to achieve them

S No	Design Parameters	Values
1	LCH Outer Diameter (OD)	0.134 inches
2	LCH Inner Diameter (ID)	0.100 inches
3	LCH Length	1.5 inches
4	Number of slots per spiral rotation	3 count
5	Total Number of Slots	180 count

Parameter	Value
Material Model	Linear Elastic-Plastic
Young’s Modulus(psi)	2.9E7
Poisson’s Ratio	0.29
Plastic Behavior (Stress, Strain)	(137000,0.00) (175000,0.198)
Ultimate Strain (%)	20

Run Order	Blocks	Input Variables			Response Variables
Run Order	Blocks	Slot Width (in)	Slot Arc Length (in)	Spiral Pitch (in)	Tensile Stiffness (lbf/in)	Torsional Stiffness (lbf-in/rad)	Bending Stiffness (lbf/in)
1	1	0.0030	0.0560	0.0200	149.60	10.93	17.00
2	1	0.0070	0.0560	0.0200	79.40	7.20	8.42
3	1	0.0030	0.0840	0.0200	31.19	5.75	3.59
4	1	0.0070	0.0840	0.0200	7.01	2.83	0.85
5	1	0.0030	0.0560	0.0350	256.20	9.88	25.17
6	1	0.0070	0.0560	0.0350	185.80	6.33	14.25
7	1	0.0030	0.0840	0.0350	101.40	3.58	9.65
8	1	0.0070	0.0840	0.0350	34.68	0.80	3.83
9	1	0.0016	0.0700	0.0275	93.83	10.30	10.20
10	1	0.0084	0.0700	0.0275	30.76	5.47	1.84
11	1	0.0050	0.0465	0.0275	136.40	12.55	15.94
12	1	0.0050	0.0935	0.0275	24.31	4.02	1.82
13	1	0.0050	0.0700	0.0149	7.12	2.99	0.29
14	1	0.0050	0.0700	0.0401	95.42	3.20	10.69
15	1	0.0050	0.0700	0.0275	47.10	7.60	5.04
16	1	0.0050	0.0700	0.0275	47.10	7.60	5.04
17	1	0.0050	0.0700	0.0275	47.10	7.60	5.04
18	1	0.0050	0.0700	0.0275	47.10	7.60	5.04
19	1	0.0050	0.0700	0.0275	47.10	7.60	5.04
20	1	0.0050	0.0700	0.0275	47.10	7.60	5.04

Regression Coefficient	Tensile Stiffness (y1)		Bending Stiffness(y2)		Torsion Stiffness(y3)
Regression Coefficient	Regression coefficient	Associated p-value for the term	Regression coefficient	Associated p-value for the term	Regression coefficient	Associated p-value for the term
η0	724	0.000	97.9	0.000	4.89	0.000
η1	-52606	0.012	-6403	0.000	-1364	0.000
η2	-15345	0.000	-1941	0.000	-255	0.000
η3	6174	0.002	168	0.001	1768	0.000
η21	3451025	0.110a	268541	0.100a	2293	0.951a
η22	103007	0.028	10641	0.006	770	0.324a
η23	176097	0.237a	15763	0.166a	-29947	0.000
η12	221879	0.570a	48858	0.117a	7084	0.334a
η13	-356175	0.624a	-45234	0.414a	2623	0.844a
η23	-137049	0.203a	-5898	0.455a	-2723	0.174a
R2 (Model)	0.885	-	0.934	-	0.983	-
R2(adj) (Model)	0.782	-	0.874	-	0.967	-
3Lack of Fit (F-value) for Model	8.57	-	15.69	-	62.63	-
Lack of Fit (P-value) for Model	0.001	-	0.000	-	0.000	-