1Porth CA (2005) Circulatory failure-shock stages. In Porth CA (eds) "Pathophysiology–Concepts of Altered Health States" (7thedn) , Lippincott Williams & Wilkins: Philadelphia 617-625.

2Peitzman AB, Billiar TR, Harbrecht BG, Kelly E, Udekwu AO, et al. (1995) Curr Probl Surg 32 : 925 - 1002.

3Zhao KS (2018) Fifty years in shock research. In: Zhao KS et al eds, "Advances in the Mechanism of Cardio-Celebral Disease", Research Signpost: Kerala (India) 1-40.

4Jin CH, Zhao KS (2009) The effects and mechanism of polydatin in shock treatment, In Zhao KS, Xu Q eds. "Molecular Mechanism of Severe Shock", Research Signpost. Kerala 192-223.

5Zhao KS, Jin C, Huang X, Liu J, Yan WS, et al. (2003) The mechanism of Polydatin in shock treatment. Clin Hemorheol Microcirc 29:211-217.

6Zhao KS (2005) Hemorheologic events in severe shock. Biorheology 42:463-477.

7Zhao KS, Junke D, Delano FA, Zweifach BW (1985) Microvascular adjustments during irreversible hemorrhagic shock in rat skeletal muscle. Microvasc Res 30:143-153.

8Morishima I, sone T, Okumura K, Tsnboi H, Kondo J, et al. (2000) Angiographic no-reflow phenomenon as a predictor of adverse low term outcome in patients treated with percutaneous transluminal coronary angioplasty for first acute myocardial infarction. J Amer College Cardiol 30:1202-1209.

9Romano M, Buffoli F, Tomasi L, Aroldi M, et al. (2009) The no-reflow phenomenon acute myocardial infarction after primary angioplasty incidence, predictive factors and long term outcomes. J Cardiovas Med 9: 59-63.

10Tsai AG, Friesenecker B, Intaglietta M (1995) Capillary flow impairment and functional capillary density. Int J Microcirc Clin Exp15:238-243.

11Intaglietta M (1999) Microcirculatory basis for the design of artificial blood. Microcirculation 6:247-258.

12Zhao KS, Huang X, Wu K, Zhu Z (1994)Rheological behavior of leukocyte in rats during hemorrhagic shock. In: Zhao KS, Jin L, Xu Q (eds) ( Advances in Burns and Trauma)) International Academic Publisher. Beijing 19-21.

13Jiang Y, Zhao KS, Li SX (1993) Computer assisted analysis of leukocyte rheological behavior in microvasculature. Chin Med J 106:883-888.

14Zhao KS (2015) Leukocyte adherence in microcirculation after burns. In: Yang Z (eds)(Chinese Burn Surgery) Springer Science: Heidelberg 19-21.

15Wu X, Huang X, Zhao KS (1996) Effect of CD11a-CD18 monoclonal antibody on the microcirculation disorder of rabbits in endotoxic shock. Med Coll PLA 11:151-154.

16Zhao K (1996) Advances in the study on rheological behavior of leukocyte during severe shock. Chin Med J 109 : 110-111.

17Zhu Z, Zhao KS (1994) Effects of crystal NO4 of Polygonum cuspidatum on the systemic circulation in rabbits and microcirculation in rat during severe hemorrhagic shock. In: Zhao KS, et al. (eds) "Advances in Burns and Trauma" International Academic Publishers: Beijing 63-68.

18Zhao KS, Wu X, Wang Y (1994) Effect of Polygonum Cuspidatum on the leukocyte activation and adhesion of rat during burn shock. In Niimi H, et al, (eds) "Progress in Microcirculation Research", Elsevier Science Ltd: Oxford 55-58.

19Zhao KS, Woo GY, Tian Y, Zhu ZG (1985) The effect of Polygonum cuspidatum on the microcirculation of burned skin. In:Chang HM (eds) "Advances in Chinese Medicinal Material Research", World Scientific Publ: Singapore 591-595.

20Zhao KS, Zhu Z, Wu K, Huang X (1990) Effect of crystal No4 of polygonum cuspidatum on cardio function of rats with hemorrhagic shock. J Med Coll PLA 5: 12-16.

21Zhao KS, Zhu ZJ, Wu KY, Huang XL (1991) Importence of enhancing cardiac function in the treatment of burn shock - Effect of crystal No4 of Polygounm cuspidate. In: Sheng C, Zhu Z, eds. "Advances in Burns", Interl Acad Pub: Beijing 31-38.

22Zhao K, Liu J, Jin C (2000) The role of membrane potential and calcium kinetic changes in the pathogenesis of vascular hyporeactivity during severe shock. Chin Med J 113:59-64.

23Zhao Q, Zhao KS (2007) Inhibition of L-type calcium channels in arteriolar smooth muscle cells is involved in the pathogenesis of vascular hyporeactivity in severe shock. Shock 28 :717-721.

24Zhao G, Zhao Y, Pan B, Liu J, Huang X, et al. (2007) Hypersensitivity of BKCa to Ca2+ sparks underlies hyporeactivity of arterial smooth muscle in shock. Circ Res. 31:493-502.

25Pan BX, Zhao GL, Huang XL, Jin JQ, Zhao KS (2004) Peroxynitrite induces arteriolar smooth muscle cells membrane hyperpolarization with arteriolar hyporeactivity in rats. Life Sci 74:1199-1210.

26Pan BX, Zhao GL, Huang XL, Zhao KS (2004) Calcium mobilization is required for peroxynitrite-mediated enhancement of spontaneous transient outward currents in arteriolar smooth muscle cells. Free Radic Biol Med. 37:823-838.

27Pan BX, Zhao GL, Huang XL, Zhao KS (2004) Mobilization of intracellular calcium by peroxynitrite in arteriolar smooth muscle cells from rats. Redox Rep 9:49-55.

28Liu J, Zhao KS (2000) The ATP-sensitive K+ channel and membrane potential in the pathogenesis of vascular hyporeactivity in severe hemorrhagic shock. Chin J Trauma 3:39-44.

29Liu J, Zhao K.S, Jin CH, Huang QB (1999) Effect of intracellular acidosis on the pathogenesis of vascular hyporeactivity in severe hemorrhagic shock. Crit Care Shock 3:112-118.

30Zhao KS, Huang X, Liu J, Huang Q, Jin C, et al. (2002) New approach to treatment of shock-restitution of vasoreactivity. Shock 18:189-192.

31Song R, Bian H, Wang X, Huang X, Zhao KS (2011) Mitochondrial injury underlies hyporeactivity of arterial smooth muscle in severe shock. Am J Hypertens 24:45-51.

32Wang X, Song R, Bian HN, Brunk UT, Zhao M, et al. (2012) a natural polyphenol, protects arterial smooth muscle cells against mitochondrial dysfunction and lysosomal destabilization following hemorrhagic shock. Am J Physiol Regul Integr Comp Physiol 302 : 805-814.

33Wang X, Song R, Chen Y, Zhao M, Zhao KS (2013) Polydatin--a new mitochondria protector for acute severe hemorrhagic shock treatment. Expert Opin Investig Drugs 22:169-179.Wang X, Song R, Chen Y, Zhao M, Zhao KS (2013) Polydatin--a new mitochondria protector for acute severe hemorrhagic shock treatment. Expert Opin Investig Drugs 22:169-179.

34Zeng Z, Chen Z, Xu S, Song R, Yang H, Zhao KS (2015) Polydatin alleviates small intestine injury during hemorrhagic shock as a SIRT1 activator. Oxid Med Cell Longev 965961.1-13.

35Zeng Z, Chen Z, Xu S, Zhang Q, Wang X, Gao Y, Zhao KS (2016) Polydatin protecting kidneys against hemorrhagic shock-induced mitochondrial dysfunction via SIRT1 activation and p53 deacetylation. Oxid Med Cell Longev. 1737185. 1-16.

36Zhao KS, Song R, Wang XM (2014) Mitochondrial dysfunction in severe hemorrhagic shock. Advances in Medicine and Biology 77: 119-133.

37Zheng ZH, Xu SQ, Zhao KS (2017) Protection against mitochondrial and cell damage a new approach to treat severe hemorrhagic shock. Advances in Medicine Biology 110: 61- 93.

38Chen YY, Wang XM, Song R, Zhao KS (2012) Changes of platelet mitochondria in rats with severe hemorrhagic shock and intervention effect of polydatin. Chin J Trauma 29: 822-889.

39Li P, Liu Y, Burns N, Zhao KS, Song R (2017) SIRT1 is required for mitochondrial biogenesis reprogramming in hypoxic human pulmonary arteriolar smooth muscle cells. Inter J Mol Med 39:1127-1136.

40Li P, Wang X, Zhao M, Song R, Zhao KS (2015) Polydatin protects hepatocytes against mitochondrial injury in acute severe hemorrhagic shock via SIRT1- SOD2 pathway. Expert Opin Ther Targets 19 : 997-1010.

41Meng X, Tan J, Li M, Song S, Miao Y, Zhang Q (2017) Sirt1: role under the condition of ischemia/hypoxia. Cell Mol Neurobiol 37:17-28.

42Siqi Xu, Youguang Gao, Qin Zhang, Siwei Wei, et al. (2016) SIRT1/3 activation by resveratrol attenuates acute kidney injury in a septic rat model. Oxidative Medicine and Cellular Longevity Volume Article. 2016, 7296092. 1-12.

43Zeng Z, Yang Y, Dai X, Xu S, Li T, et al. (2016) Polydatin ameliorates injury to the small intestine induced by hemorrhagic shock via SIRT3 activation-mediated mitochondrial protection. Expert Opin Ther Targets 20:645-652.

44Yang H, Gu ZT, Li L, Maegele M, Zhou BY, et al. (2017) SIRT1 plays a neuroprotective role in traumatic brain injury in rats via inhibiting the p38 MAPK pathway. Acta Pharmacol Sin 38:168-181.

45Zeng Z, Chen Z, Li T, Zhang J, Gao Y, et al. (2015) Polydatin: a new therapeutic agent against multiorgan dysfunction. J Surg Res 198:192-199.