Figure 1 Three pathogenesis factors in severe shock (shock stage III) [3].

Figure 2 The schema for the etiology of vascular hyporeactivity in severe shock [3]

Figure 3Ultrastructural alterations of ASMC mitochondria in severe shock [3]. A: normal mitochondria (some arrowed) in the control group. B: mitochondria swollen with poorly defined crystae in the shock group. These alterations are partially prevented in the shock + CsA (C), shock + RVS (D), and shock + PD groups (E), respectively. Scale bars: 1.0μm.

Figure 4SIRT1/3 low activity with over acetylation of mitochondrial-related protein in shock [3]