Figure 1 Box plots of liver stiffness values obtained with Point SWS measurements and TEin comparison. The top and the bottom of the boxes are the upper and lower limits of the 95% confidence interval. The line through the middle of each box represents the mean value.

Figure 2 Box plots of liver stiffness values obtained with SWS imaging and TE. The top and the bottom of the boxes are the upper and lower limits of the 95% confidence interval. The line through the middle of each box represents the mean value.

Figure 3a) Receiver operating characteristic (ROC) curve for shear wave elastography in patients with fibrosis F2 vs F0; b) Receiver operating characteristic (ROC) curve for shear wave elastography in patients with fibrosis F3 vs F2; c) Receiver operating characteristic (ROC) curve for shear wave elastography for patients with fibrosis F4 vs F3.

	PATIENTS		HEALTHY PARTECIPANTS
	Median (IQR) or Absolute Count	Range	Median (IQR) or Absolute Count	Range
MALE	36		5
FEMALE AGE (YEARS)	12 61(18)	39 - 83	6 50 (15)	35 - 62
BMI (KG/M2) ALT (U/L)	24,2(5) 32(18,8)	18 - 36 11,1 - 282	22,9 (5,2) 19 (9,6)	20,3 – 27,8 12 – 27,5
AST (U/L) GGT(U/L)	35,5(32,9) 45(50,6)	16 - 190 12 - 221	17(6,7) 16(5)	10,3 - 21 10 -25
ALKALINE PHOSPHATASE (U/L)	95(37,2)	64 - 138	73(31,3)	45 - 89
PLATELETS COUNT (103/L)	211(88)	108 - 328	268(42)	230-335

Table 1:Patients and Healthy Partecipants characteristics.Data are reported as medians and ranges or as absolute count. BMI: body mass index. ALT: alanine transaminase. AST: aspartate transaminase. GGT: gamma gluthamyl synthetase.

	F≥2	F≥3	F=4
Cut off (kPa)	6,2	7,65	13
Sensitivity (%)	80	86	100
Specificity (%)	82	68	79
AUROC (95% CI)	0,85 (0,73 – 0,98)	0,74 (0,57 – 0,91)	0,93 (0,83 – 1)

Table 2: Operative characteristics of shear-wave elastography in predicting fibrosis stages