|
+CE (n=422) |
- CE (n=483) |
p |
Mean age,years |
78.7±7.7 |
82.4±7.7 |
<0.0001 |
Female gender, |
211(50.1%) |
325(67.3%) |
<0.0001 |
Median weight, kg |
74.8 (62.5-86.6) |
66.2(56.7-81.6) |
<0.0001 |
Mean SBP, mmHg |
147.1 ±29.2 |
150.7±28.4 |
0.06 |
SBP <100 mmHg |
14 (3.3%) |
12(2.5%) |
0.32 |
Mean HR |
85.4(±17.9) |
84.5(±16.0) |
0.47 |
HR >100 |
73 (17.3%) |
78(16.1%) |
0.47 |
Median GCS |
15 (14-15) |
15 (15-15) |
0.03 |
AIS Head >3 |
152(36.1% ) |
157 (32.5%) |
0.26 |
Median ISS |
16(9-21) |
10(9-17) |
<0.0001 |
Median Scr, mg/dl |
0.87 (0.7-1.07) |
0.92(0.7-1.26) |
0.003 |
Scr> 1.5 mg/dl |
13 (3.1%) |
73 (15.1%) |
<0.0001 |
eGFR>60 ml/min/1.73m2 |
311(73.9%) |
261(54.0%) |
<0.0001 |
eGFR=60 and >30 ml/min/1.73m2 |
106(25.2%) |
185 (38.3%) |
|
eGFR=30 ml/min/1.73m2 |
5(1.2%) |
37(7.6%) |
|
Diabetes mellitus |
110 (26.1%) |
117 (24.2% ) |
0.51 |
Received packed RBC prior to or in ED |
12(2.9%) |
6(1.2%) |
0.08 |
Renal or bladder injuries |
3 (0.7%) |
1 (0.2%) |
0.34 |
Intubated prior to or in ED |
40(9.5%) |
17(3.5%) |
<0.0001 |
Median volume of contrast in first 48 hours, ml a |
100 (100-100) |
---- |
--- |
AKI |
21(5.0%) |
31(6.2%) |
0.36 |
30-day mortality |
35 (8.3%) |
26 (5.4%) |
0.08 |
Table1 Characteristics of patients with and without contrast exposure
|
AKI(n=52) |
No AKI (n=853) |
p |
Mean age,years |
81.1 (±8.2) |
80.6(±7.9) |
0.67 |
Female gender |
26 (50.0%) |
510 (59.9%) |
0.16 |
Median weight, kg |
81.8 (68.5-98.4) |
69.4(58.1-83.6) |
0.001 |
Mean SBP, mmHg |
147.6(±30.7) |
149.1(±28.8) |
0.74 |
SBP<100 mmHg |
3 (5.7%) |
24 (2.8%) |
0.20 |
Mean HR |
79.9 (±14.2) |
85.2(±17.0) |
0.01 |
HR>100 |
6 (11.5%) |
143(16.7%) |
0.4 |
Median GCS |
15(15-15) |
15(14-15) |
0.17 |
AIS Head >3 |
16 (30.7%) |
293 (34.3%) |
0.65 |
Median ISS |
12 (9-17) |
13(9-18) |
0.77 |
Median Scr, mg/dl |
1.07(0.74-1.34) |
0.88(0.70-1.12) |
0.03 |
Scr>1.5 mg/dl |
8 (15.4%) |
78 (9.2%) |
0.14 |
eGFR>60 ml/min/1.73m2 |
27(51.9%) |
545(63.9%) |
0.08 |
eGFR>30 and =60 ml/min/1.73m2 |
21(40.4%) |
270 (31.6%) |
|
eGFR=30 ml/min/1.73m2 |
4(7.7%) |
38(4.5%) |
|
Diabetes mellitus |
20(38.5%) |
207(24.5%) |
0.02 |
Received packed RBC prior to or in ED |
2 (3.9%) |
16 (1.9%) |
0.28 |
Renal or bladder injuries |
0(0%) |
4(0.47%) |
1.0 |
Intubated prior to or in the ED |
2(3.9%) |
55(6.5%) |
0.77 |
+CE |
21 (40.4%) |
400(46.9%) |
0.36 |
30-day mortality |
7(13.5%) |
54(6.4%) |
0.08 |
Table2 Univariate analysis of predictors associated with early AKI
|
+CE |
-CE |
P |
eGFR =30 ml/min/1.73m2 |
|
|
0.41a |
AKI |
1 |
3 |
|
No AKI |
4 |
34 |
|
|
|
|
|
eGFR>30 and = 60 ml/min/1.73m2 |
|
|
0.82a |
AKI |
7 |
14 |
|
No AKI |
99 |
171 |
|
|
|
|
|
GFR3>60 ml/min/1.73m2 |
|
|
0.56a |
AKI |
13 |
14 |
|
No AKI |
298 |
247 |
|
Table3 Association between contrast exposure CE and early AKI stratified by estimated glomerular filtration rate
aFisher exact test
Mantel-Haenszel common odds ratio: 0.85 (95% C.I. 0.45, 1.56)
Breslow– Day test for homogeneity of odds, p=0.59
|
+CE |
-CE |
P |
Scr =1.5 |
|
|
0.64a |
AKI |
20 |
24 |
|
No AKI |
388 |
386 |
|
|
|
|
|
Scr>1.5 |
|
|
1.0a |
AKI |
1 |
7 |
|
No AKI |
12 |
66 |
|
Table4 Association betweencontrast exposure and early AKI stratified by admission serum creatinine
aFisher’s exact test
Mantel-Haenszel common odds ratio 0.83 (95% C.I. 0.44-1.54)
Breslow– Day test for homogeneity of odds, p=0.96
|
Nonsurvivors(n=61) |
Survivors (n=844) |
p |
Mean age,years |
83.2±7.7 |
80.5±7.9 |
0.011 |
Female gender |
28 (45.9%) |
508 (60.2%) |
0.027 |
Median weight, kg |
72.5 (55.2-84.88) |
69.9(59.0-83.9) |
0.84 |
Mean SBP, mmHg |
144.2±38.9 |
149.3±28.0 |
0.32 |
SBP<100 mmHg |
6 (9.8%) |
21(2.5%) |
0.007 |
Mean HR |
88.2±20.4 |
84.7±16.6 |
0.20 |
HR>100 |
14 (23.0%) |
136 (16.1%) |
0.20 |
Median GCS |
14(3-15) |
15(15-15) |
<0.0001 |
AIS Head >3 |
40(65.6%) |
269(31.9%) |
<0.0001 |
Median ISS |
19 (15-26)
|
13 (9-17) |
<0.0001 |
Median Scr, mg dl-1 |
1.11(0.82-1.36) |
0.89(0.70-1.11) |
0.0003 |
Scr>1.5 mg dl-1 |
12 (19.7%) |
74 (8.8%) |
0.011 |
eGFR>60 ml/min/1.73m2 |
25 (41.0%) |
547 (64.9%) |
<0.0001 |
eGFR>30 and ≤60 ml/min/1.73m2 |
33 (54.1%) |
258 (30.6%) |
|
eGFR≤30 ml/min/1.73m2 |
3 (4.9%) |
39 (4.6%) |
|
Diabetes mellitus |
209 (32.8%) |
207(24.5%) |
0.15 |
Received packed RBC prior to or in ED |
8 (13.1%) |
10 (1.2%) |
<0.0001 |
Renal or bladder injuries |
0 |
4 (0.47%) |
1.0 |
Intubated prior to or in the ED |
27 (44.3%) |
30 (3.6%) |
<0.0001 |
CE (n, %) |
35(57.8%) |
386(45.8%) |
0.08 |
Early AKI |
7 (11.5%) |
45 (5.3%) |
0.077 |
Table5 Univariate analysis of predictors of 30-day mortality
Variable |
Coefficient |
Odds ratio (95% C.I.) |
p |
Constant |
-5.71 |
|
0.007 |
Age |
0.043 |
1.05 (1.00-1.09) |
0.033 |
Female gender |
-0.59 |
0.55 (0.30- 1.03) |
0.063 |
GCS |
-0.26 |
0.77 (0.72- 0.83) |
<0.0001 |
ISS |
0.045 |
1.05 (1.01-1.08) |
0.006 |
GFR < 30 ml/min/1.73m2 |
0.44 |
1.57 (0.36-6.89) |
0.55 |
GFR >30 or ≤ 60 ml/min/1.73m2 |
0.78 |
2.19 (1.13-4.26) |
0.021 |
Received blood in or prior to the ED |
1.34 |
3.63 (1.15-12.15) |
0.034 |
HR |
0.016 |
1.02 (1.00-1.03) |
0.087 |
AKI |
1.07 |
2.90 (1.08- 7.78) |
0.034 |
CE |
0.17 |
1.18 (0.61- 2.30) |
0.61 |
Pre-existing diabetes |
0.44 |
1.56 (0.79-3.06) |
0.22 |
Table6 Multivariate analysis of predictors of 30-day mortality by stepwise logistic regression.
areferent is eGFR>60 ml/min/1.73m2
Chi-square goodness of fit tests: Pearson,χ2=815.03, p=0.9; Deviance,χ2 =321.57, p=1.0