First Line Treatment |
Protective clothing to prevent UV light exposure, cooling compounds (wet towel, ice packs) |
Oral antihistamines (hydroxyzine, loratadine, cetirizine) |
Topical local anesthetics agents (capsaicin) |
Oral anti-depressants (amitriptyline, doxepin, fluoxetine) |
Oral anti-convulsants (pregabalin, gabapentin) |
Second Line Treatment |
Oral antipsychotics (risperidone, pimozide, chlorpromazine) |
Combination therapy (amitriptyline-ketamine cream, amitriptyline-ketamine-lidocaine cream) |
NK-1 antagonists (aprepitant) |
Alternative therapies: botulinum A toxin |
Surgical interventions (cervical spine manipulation, discectomy) |
Table 1 First and Second Line Therapy in the Treatment of BRP [2,5,6].