
Figure 1: Brain MRI (diffusion-weighted imaging) showing restricted diffusion predominantly in the lateral and paramedian aspects of the left parietal lobe,the paramedian left frontal lobe, left insular cortex and basal ganglia bilaterally
|
Value |
Reference range |
Complete blood count |
WBC: 9.2 × 109/L |
3.5-10 × 109/L |
Neutrophils: 68.3% |
40-75% |
|
Lymphocytes: 22.6% |
20-45% |
|
Monocytes: 8.2% |
4-12% |
|
Eosinophils: 0.3% |
0-7% |
|
Metabolic panel |
Sodium: 141 mmol/L |
135-145 mmol/L |
|
Potassium: 4.3 mmol/L |
3.5-5.3 mmol/L |
BUN: 13 mg/dL |
6-23 mg/dL |
|
Calcium: 9.5 mg/dL |
8.6-10.4 mg/dL |
|
Ammonia: 17 µmol/L |
11-51 µmol/L |
|
B12: 504 pg/mL |
232-1,245 pg/mL |
|
Folate: 18.8 ng/mL |
> 4 ng/mL |
|
Autoimmunity |
ESR: 25 mm/hr |
< 29 mm/hr |
CRP: 4.3 mg/L |
< 8 mg/L |
|
ANA: 1:80 |
< 1:40 |
|
Ro/SSA, La/SSB, Smith, RNP, Scl-70, JO-1: Negative |
Negative |
|
Anti-PR3, Anti-MPO: Negative |
Negative |
|
Serum |
HIV Ab: Negative |
Negative |
RPR: Negative |
Negative |
|
Lyme Ab: Negative |
Negative |
|
CSF cell count |
WBC: 1 cells/mm3 |
0-5 cells/mm3 |
RBC: 8 cells/mm3 |
0 cells/mm3 |
|
CSF cytology |
Rare scattered mononuclear cells, mostly benign lymphocytes |
|
CSF analysis |
Protein: 79 mg/dL |
15-45 mg/dL |
CSF/serum glucose ratio: 60% |
50-90% |
|
RT-QuIC for PrP: Positive |
Negative |
|
Protein 14-3-3: Positive |
Negative |
|
T-tau protein: 10,077 pg/mL |
0-1,149 pg/mL |
|
CSF microbiology |
Gram stain: No organism |
Negative |
Culture: No growth |
Negative |
|
AFB: No growth |
Negative |
|
HSV 1-2: Negative |
Negative |
|
Enterovirus: Negative |
Negative |
|
Cryptococcal Ag: Negative |
Negative |
|
Borrelia: Negative |
Negative |
|
CSF autoimmune panel |
NMDA-R Ab, AMPA-R Ab, DPPX Ab, CASPR2-IgG, LGI1-IgG, GABA-B-R, Ab: Negative |
Negative |
Abnormal results are shown in bold.
Ab: antibody; AFB: acid-fast bacteria; Ag: antigen; AMPA-RAb:
Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antibody; ANA: antinuclear antibody; BUN: blood urea nitrogen; CASPR2- IgG: Contactin-associated protein-like 2 immunoglobulin G; CRP: C-reactive protein; DPPX Ab: Dipeptidyl-peptidase-like protein antibody; ESR: erythrocyte sedimentation rate; GABA-B-R Ab: Gamma Aminobutyric acid receptor type B antibody; HIV: human immunodeficiency virus; HSV: herpes simplex virus; LGI1-IgG: Leucine-Rich glioma-inactivated protein 1 immunoglobulin G; MPO: myeloperoxidase; NM- DA-R Ab: N-methyl-d-aspartate receptor antibody; PR3: proteinase 3; PrP: prion protein; RBC: red blood cells; RPR: rapid plasma reagin; RT-QuIC: real-time quaking-induced conversion; WBC: white blood cells
Table 1: Relevant laboratory analysis
OR |
Table 2: CDCʼs Diagnostic Criteria for Probable CJD
Figure 1: Brain MRI (diffusion-weighted imaging) showing restricted diffusion predominantly in the lateral and paramedian aspects of the left parietal lobe,the paramedian left frontal lobe, left insular cortex and basal ganglia bilaterally
Tables at a glance
Figures at a glance