(DE) -Ubiquitination in The TGF-β Pathway
Received Date: July 18, 2013; Accepted Date: August 14, 2013; Published Date: August 16, 2013
Citation: Pieter Eichhorn, et al. (2013) (DE) -Ubiquitination in The TGF-β Pathway. J Cancer Res Therap Oncol 1: 1-6
Abstract
Aberrations in the enzymes that modify ubiquitin moieties have been observed to cause a myriad of diseases, including cancer. Therefore a better understanding of these enzymes and their substrates will lead to the identification of prospective druggable targets. Here we discuss the role of ubiquitin modifying enzymes in the canonical TGF-β pathway highlighting the ubiquitin regulating enzymes, which may potentially be targeted by small molecule inhibitors.