Journal of Cancer Research and Therapeutic Oncology
Review Article

(DE) -Ubiquitination in The TGF-β Pathway

Received Date: July 18, 2013; Accepted Date: August 14, 2013; Published Date: August 16, 2013

Citation: Pieter Eichhorn, et al. (2013) (DE) -Ubiquitination in The TGF-β Pathway. J Cancer Res Therap Oncol 1: 1-6

Abstract

Aberrations in the enzymes that modify ubiquitin moieties have been observed to cause a myriad of diseases, including cancer. Therefore a better understanding of these enzymes and their substrates will lead to the identification of prospective druggable targets. Here we discuss the role of ubiquitin modifying enzymes in the canonical TGF-β pathway highlighting the ubiquitin regulating enzymes, which may potentially be targeted by small molecule inhibitors.

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