Single strand break (SSBs) and base damage lesions which do not distort the helical structure of the DNA are repaired by base excision repair (BER), bulky adducts and cross-linkages are repaired by nucleotide excision repair (NER) (See figure 1 for DNA damage types and appropriate repair routes). Double strand breaks (DSBs) are resolved through a more complex repair mechanisms involving two separate intricate pathways referred to as Non-homologous end-joining (NHEJ) and Homologous recombination (HR)
Figure 1: Forms of DNA damage, their corresponding repair pathways and signalling complexes
Tables at a glance
Figures at a glance