Clinicopathologic and demographic characteristics

No RT
(N=422)After matching

RT
(N=422)After matching

p-value After matching

No RT
(N=1752)Before matching

RT
(N=422)Before matching

P-value Before matching

Sex

0.529

< 0.001

Female

168 (39.8%)

177 (41.9%)

903 (51.5%)

177 (41.9%)

Male

254 (60.2%)

245 (58.1%)

849 (48.5%)

245 (58.1%)

Age

0.680

0.143

18-64

208 (49.3%)

214 (50.7%)

819 (46.7%)

214 (50.7%)

65+

214 (50.7%)

208 (49.3%)

933 (53.3%)

208 (49.3%)

Race

0.789

0.256

Non-Hispanic Asian or Pacific Islander

28 (6.6%)

34 (8.1%)

134 (7.6%)

34 (8.1%)

Non-Hispanic Black

40 (9.5%)

45 (10.7%)

145 (8.3%)

45 (10.7%)

Non-Hispanic White

334 (79.1%)

324 (76.8%)

1364 (77.9%)

324 (76.8%)

Other

20 (4.7%)

19 (4.5%)

109 (6.2%)

19 (4.5%)

Histologic Grade

0.673

< 0.001

Grade I-II

165 (39.1%)

171 (40.5%)

925 (52.8%)

171 (40.5%)

Grade III-IV

257 (60.9%)

251 (59.5%)

827 (47.2%)

251 (59.5%)

Marital status at diagnosis

0.435

0.061

Married

256 (60.7%)

267 (63.3%)

1021 (58.3%)

267 (63.3%)

Not married/ divorced/ widowed

166 (39.3%)

155 (36.7%)

731 (41.7%)

155 (36.7%)

Pleural Invasion

0.575

< 0.001

Visceral pleura invasion

104 (24.6%)

116 (27.5%)

819 (46.7%)

116 (27.5%)

Parietal pleura invasion

153 (36.3%)

153 (36.3%)

190 (10.8%)

153 (36.3%)

Tumor extends to pleura unspecified if visceral or parietal

165 (39.1%)

153 (36.3%)

743 (42.4%)

153 (36.3%)

Size and extent of primary tumor “T”

0.288

< 0.001

T2

113 (26.8%)

111 (26.3%)

994 (56.7%)

111 (26.3%)

T3

264 (62.6%)

251 (59.5%)

632 (36.1%)

251 (59.5%)

T4

45 (10.7%)

60 (14.2%)

126 (7.2%)

60 (14.2%)

Tumor Histology

0.559

< 0.001

Adenocarcinoma

226 (53.6%)

236 (55.9%)

1230 (70.2%)

236 (55.9%)

SCC

173 (41.0%)

169 (40.0%)

468 (26.7%)

169 (40.0%)

Other histology

23 (5.5%)

17 (4.0%)

54 (3.1%)

17 (4.0%)

Clinical and demographic characteristics

Value

5 year CSS

p.value Univariate analysis

aHR

p.value Multivariate analysis

Age

18-64

0.63
(0.58-0.68)

(ref)

(ref)

(ref)

65+

0.55 (0.5-0.6)

0.009*

1.32

0.012*

(1.06-1.63)

Sex

Female

0.63
(0.58-0.69)

(ref)

(ref)

(ref)

Male

0.56

0.004*

1.33

0.012*

(0.52-0.61)

(1.06-1.66)

Race

Non-Hispanic Asian or Pacific Islander

0.52
(0.4-0.67)

(ref)

(ref)

(ref)

Non-Hispanic Black

0.64

0.273

0.79

0.373

(0.54-0.76)

(0.48-1.32)

Non-Hispanic White

0.59

0.321

0.82

0.314

(0.55-0.63)

(0.56-1.21)

Other

0.64

0.232

0.69

0.273

(0.49-0.83)

(0.36-1.34)

Histologic

I-II

0.63

(ref)

(ref)

(ref)

Grade

(0.58-0.69)

III-IV

0.56

0.078

1.16

0.211

(0.52-0.61)

(0.92-1.45)

Size and extent

T2

0.66

(ref)

(ref)

(ref)

of Tumor

(0.6-0.73)

T3

0.57

0.004*

1.48

0.008*

(0.52-0.61)

(1.11-1.98)

T4

0.55

0.011*

1.55

0.021*

(0.45-0.66)

(1.07-2.25)

Marital status

Married

0.58

(ref)

(ref)

(ref)

at diagnosis

(0.53-0.63)

Not married-

0.61

0.458

0.98

0.887

divorced- widowed

(0.56-0.67)

(0.79-1.23)

Pleural

Visceral Pleural

0.6

(ref)

(ref)

(ref)

Invasion

Invasion (PL1/PL2)

(0.53-0.67)

Parietal Pleura

0.58

0.787

0.81

0.162

invasion (PL3)

(0.53-0.65)

(0.6-1.09)

Tumor extends to pleura unspecified if visceral or parietal

0.59
(0.54-0.65)

0.701

0.88
(0.67-1.16)

0.372

Tumor

Adenocarcinoma

0.62

(ref)

(ref)

(ref)

Histology

(0.57-0.67)

SCC

0.56

0.064

1.16

0.204

(0.5-0.62)

(0.92-1.45)

Other

0.55

0.143

1.54

0.071

(0.41-0.74)

(0.96-2.46)

Clinical and demographic characteristics

Value

5 year OS

p.value Univariate

aHR

p.value Multiv

Age

18-64

0.56
(0.52-0.61)

(ref)

(ref)

(ref)

65+

0.42
(0.38-0.48)

<0.001***

1.45
(1.2-1.74)

<0.001***

Sex

Female

0.55 (0.5-0.61)

(ref)

(ref)

(ref)

Male

0.46 (0.41-0.5)

<0.001***

1.39
(1.14-1.69)

<0.001***

Race

Non-Hispanic Asian or Pacific Islander

0.47
(0.35-0.62)

(ref)

(ref)

(ref)

Non-Hispanic Black

0.58 (0.48-0.7)

0.471

0.92
(0.58-1.48)

0.736

Non-Hispanic White

0.49
(0.45-0.53)

0.926

1.01
(0.7-1.45)

0.966

Other

0.46
(0.32-0.66)

0.902

1.06
(0.61-1.83)

0.835

Histologic grade

I-II

0.55 (0.5-0.61)

(ref)

(ref)

(ref)

III-IV

0.46
(0.42-0.51)

0.043*

1.18
(0.97-1.43)

0.1

Size and extent of Tumor

T2

0.57
(0.51-0.65)

(ref)

(ref)

(ref)

T3

0.48
(0.44-0.53)

0.009*

1.33
(1.03-1.7)

0.028*

T4

0.4 (0.31-0.51)

<0.001***

1.63
(1.2-2.22)

0.002*

Marital status at diagnosis

Married

0.48
(0.44-0.53)

(ref)

(ref)

(ref)

Not married/ divorced/ widowed

0.51
(0.46-0.57)

0.353

0.98
(0.81-1.19)

0.84

Pleural Invasion

Viseral Pleural Invasion (PL1/PL2)

0.53 (0.47-0.6)

(ref)

(ref)

(ref)

Parietal Pleura invasion (PL3)

0.48
(0.43-0.55)

0.506

0.87
(0.67-1.13)

0.29

Tumor extends to pleura unspecified if visceral or parietal

0.48
(0.43-0.54)

0.514

0.98
(0.77-1.25)

0.892

Tumor Histology

Adenocarcinoma

0.54
(0.49-0.59)

(ref)

(ref)

(ref)

SCC

0.43
(0.38-0.49)

0.002*

1.24
(1.02-1.5)

0.028*

Other

0.51 (0.38-0.7)

0.307

1.36
(0.88-2.09)

0.166

Clinical and demographic characteristics

Value

No RT

RT

p.value

aHR

p.valuemultiv

Age

18-64

0.64

0.49 (0.43-

<0.001***

1.73

<0.001***

(0.57-0.71)

(1.3-2.31)

0.56)

65+

0.49

0.36 (0.3-

0.002*

1.52

<0.001***

(0.42-0.57)

(1.19-1.95)

0.44)

Race

Non-Hispanic

0.54

0.4 (0.27-

0.108

2.08

0.055

Asian

(0.37-0.8)

(0.99-4.4)

or Pacific Islander

0.61)

Non-Hispanic

0.59

0.57

0.55

1.31

0.429

Black

(0.46-0.77)

(0.45-0.74)

(0.67-2.56)

Non-Hispanic

0.56

0.41

<0.001***

1.61

<0.001***

White

(0.51-0.62)

(0.36-0.47)

(1.31-1.99)

Other

0.53

0.38

0.295

1.61

0.324

(0.35-0.81)

(0.21-0.7)

(0.62-4.16)

Sex

Female

0.61

0.5

0.004*

1.58

0.004*

(0.53-0.69)

(0.43-0.58)

(1.16-2.17)

Male

0.53
(0.47-0.6)

0.38
(0.32-0.45)

<0.001***

1.6
(1.27-2.01)

<0.001***

Size and extent of tumor

T2

0.69
(0.6-0.79)

0.46
(0.37-0.56)

<0.001***

2.29
(1.53-3.43)

<0.001***

T3

0.53
(0.46-0.59)

0.43
(0.37-0.5)

0.004*

1.52
(1.2-1.92)

<0.001***

T4

0.43
(0.3-0.62)

0.38
(0.27-0.52)

0.308

1.11
(0.67-1.85)

0.687

Histologic Grade

I-II

0.63
(0.55-0.71)

0.47
(0.4-0.55)

<0.001***

1.78
(1.3-2.43)

<0.001***

III-IV

0.52
(0.46-0.59)

0.4
(0.34-0.47)

0.001*

1.5
(1.19-1.9)

<0.001***

Tumor Histology

Adenocarcinoma

0.6
(0.54-0.68)

0.47
(0.41-0.54)

<0.001***

1.66
(1.28-2.16)

<0.001***

SCC

0.5
(0.42-0.58)

0.37
(0.3-0.45)

0.009*

1.52
(1.15-2.01)

0.004*

Other

0.65 (0.60
- 0.67)

0.41
(0.23-0.73)

0.159

2.24
(0.9-5.6)

0.085

Marital status at diagnosis

Married

0.56
(0.49-0.62)

0.42
(0.36-0.48)

<0.001***

1.62
(1.28-2.05)

<0.001***

Not married- divorced- widowed

0.57
(0.49-0.65)

0.45
(0.38-0.54)

0.011*

1.56
(1.14-2.12)

0.005*

Visceral Parietal Invasion

Visceral Pleural Invasion (PL1/PL2)

0.65
(0.56-0.75)

0.43
(0.35-0.54)

<0.001***

2.15
(1.44-3.19)

<0.001***

Parietal Pleural Invasion (PL3)

0.54
(0.46-0.63)

0.43
(0.35-0.52)

0.038*

1.45
(1.06-1.98)

0.019*

Tumor extends to pleura unspecified if visceral or parietal

0.53
(0.46-0.62)

0.43
(0.35-0.51)

0.01*

1.52
(1.13-2.05)

0.006*

Clinical and demographic characteristics

Value

No RT
Group

RT Group

p.value

aHR

p.value multivariate

Age

18-64

0.7
(0.63-0.77)

0.56 (0.49-

<0.001***

1.78 (1.29-

<0.001***

0.63)

2.45)

65+

0.59
(0.52-0.66)

0.51 (0.44-

0.067

1.35 (1.01-

0.042*

0.59)

1.81)

Sex

Female

0.66
(0.59-0.75)

0.6
(0.53-0.68)

0.081

1.34
(0.94-1.91)

0.103

Male

0.63
(0.57-0.7)

0.49
(0.43-0.56)

0.001*

1.6
(1.22-2.1)

<0.001***

Race

Non-Hispanic Asian or Pacific Islander

0.64
(0.47-0.87)

0.42
(0.28-0.63)

0.063

2.28
(1.02-5.11)

0.045*

Non-Hispanic Black

0.68
(0.55-0.85)

0.61
(0.48-0.77)

0.417

1.7
(0.8-3.62)

0.17

Non-Hispanic White

0.64
(0.59-0.7)

0.53
(0.48-0.6)

0.002*

1.49
(1.18-1.9)

0.001*

Other

0.64
(0.45-0.93)

0.63
(0.43-0.93)

0.872

2.13
(0.56-8.05)

0.267

Size and extent of Tumor

T2

0.75
(0.67-0.85)

0.57
(0.48-0.68)

0.002*

2.11
(1.32-3.38)

0.002*

T3

0.6
(0.54-0.67)

0.53
(0.47-0.6)

0.032*

1.42
(1.09-1.85)

0.01*

T4

0.59
(0.45-0.77)

0.52
(0.4-0.68)

0.296

1.39
(0.73-2.62)

0.313

Histologic Grade

I-II

0.68
(0.61-0.77)

0.58
(0.51-0.67)

0.018*

1.56
(1.09-2.22)

0.015*

III-IV

0.62
(0.55-0.68)

0.51
(0.44-0.58)

0.006*

1.48
(1.13-1.94)

0.004*

Histology

Adenocarcinoma

0.68
(0.62-0.75)

0.56
(0.5-0.63)

0.003*

1.59
(1.18-2.14)

0.002*

SCC

0.6
(0.52-0.69)

0.51
(0.43-0.6)

0.067

1.46
(1.05-2.03)

0.026*

Other

0.65 (0.60 -
0.67)

0.49
(0.29-0.82)

0.266

1.94
(0.72-5.21)

0.189

Marital status at diagnosis

Married

0.62
(0.56-0.69)

0.53
(0.47-0.6)

0.009*

1.47
(1.12-1.93)

0.005*

Not married/ divorced/ widowed

0.67
(0.6-0.76)

0.55
(0.47-0.63)

0.015*

1.64
(1.15-2.35)

0.007*

Pleural Invasion

Viseral Pleural Invasion (PL1/PL2)

0.69
(0.6-0.79)

0.52
(0.43-0.62)

0.006*

1.87
(1.21-2.88)

0.005*

Parietal Pleura invasion (PL3)

0.64
(0.56-0.73)

0.52
(0.45-0.62)

0.046*

1.5
(1.05-2.14)

0.027*

Tumor extends to pleura unspecified if visceral or parietal

0.62
(0.54-0.7)

0.57
(0.49-0.66)

0.122

1.44
(1.01-2.05)

0.044*