Figure 1 Bladder wall masses biopsy showing low-grade papillary transitional epithelium carcinoma, H-E ×100

Figure 2 A) Bone marrow aspirate smear demonstrating large numbers of plasma cells with eccentric round nucleus and condensed chromatin, some of plasmablast with basophilic cytoplasm. Wright-Giemsa. ×1000. B) Bone marrow trephine biopsy showing extensive infiltration of neoplastic plasma cells, H-E ×100

Authors,
year

Age
/sex

Malignancies before MM

Treatment before MM

Malignancies-MM interval

SPE/IE

Treatment after MM

Outcome

Abnormal chro-
-mosome/gene

Drasin H
et al., 1979

50,F

Lung Lymphocytic
lymphoma

Radiation therapy

9 years

IgG

MOP

Died after
28 months

NS

Claudia W et al., 1999

57,M

T-cell lymphoma

PUVA + INFa2b

2 years

IgG
?

alkeran+ decortin

Died after
28 months

NS

Muzaffer K et al., 2013

68 M

Colon adenocarcinoma gastrointestinal stromal tumor
lung cancer

folinic acid 5-fl
urouracil irinote
can bevacizumab

15 months

IgG
?

Chemotherapy and biphosphomate

Died after
18 months

K-RAS mutation
t(4;14),17p13,

Vassilia G. et al., 2005

68 M

CML

INF a
Imatinib

18 months

IgG
?

MP + Imatinib

Alive after 8 months

t(9;14;22)(q34;q24;q11)

Francesc C et al., 1995

74 F

ET

INF a2b
P32

61 months

IgA
?

MP

Died after
3 months

NS

Philip M et al., 1995

94 F

ET

Alkylating + thiotepa

11 years

IgA
?

MP

NA

NS

Montserral R et al., 1990

38 F

CNL

Without any therapy

7 years

?

MP

Alive after 5 months

46XX; Ph(-)

Michalis M et al., 2009

63 F

CML

Imatinib

65 months

IgA
?

TD + Imatinib
VAD Velcode

Alive after two years

NS

Pérez LM et al., 2007

63 M

Prostate ade-
-nocarcinoma

NA

NA

NA

NA

NA

NS

Rogulj IM et al., 2011

NA

CLL

NA

11 years

 

Without any therapy

NA

NS

Prósper F,et al, 1992

NA

ET

NA

5 years

NA

NA

NA

NS

Dorn GW et al., 1984

NA M

Hodgkin's disease

NA

NA

NA

NA

NA

NS

Tzilves D et al., 2007

74 M

gastrointestinal stromal tumor

Imatinib

1 month

IgA
?

MP + Imatinib

Died after
6 months

NS

Nowakowsk et al., 2007

65 M

Penile myeloid sarcoma

NA

NA

NA

NA

Died after
16 months

NS

Monique A, 2010

71 M

Merkel cell carcin-
-oma CLL

RFC

14 years

?

CTX+P

Died after
6 months

NS

Hashimoto S et al., 1992

71 M

Diffuse large B cell malignant lymphoma

CHOP

32 months

IgA
?

Combination chemotherap

alive

NS

Derghazarian et al., 1974

65F

CML

busulphan

3 years

IgG
?

L

NA

46XX;.22q-;
Ph (+)

Zoumbos et al., 1987

57M

CNL

busulphan

5 years

?

NA

NA

NS

Majhail NS
et al., 2003

85 M

ET

hydroxyurea

50 months

IgG
?

Without any therapy

Refuse any treatment

NS

Majhail NS et al., 2003

54M

ET

Hydroxyurea

29 months

IgG
?

MP
DOP

Died after 5 years

NS

Derghazarian C et al., 1974

65 F

ET

busulfan

7 years

IgG
?

Radiotherapy
L + busulfan

Alive after 2 years

NS

Kough RH et al., 1978

75F

CLL

Chlorambucil

80 months

IgA?

MP
CTX

Died after 3 year

NS

Kough RH et al., 1978

58 M

CLL

Chlorambucil

4 years

?

MP

Died after 1 year

NS

Table 1:Clinical data from cases of MM following other malignancies CTX, cyclophosphamide; L, Phenylalanine mustard; MP, melphalan + prednisone; TD,Thalidomide + dexamethasone; VAD vincristine + liposomal doxorubicin + dexamethasone; MOP, MP + Vincristine; DOP, vincristine + doxorubicin + dexamehasone; RFC, fludarabine + cyclophosphamide + rituxmab; CHOP doxorubicin + cyclophosphamide + vinscristine + rpednisolone; F, female; M, male; NA, not available; NS, not stated; SPE, serum protein electrophoresis; IE, immunoelectrophrosis; + combined with; - negative; ? increased; CNL, chronic neutrophilic leukaemia; CLL,chronic lymphocytic leukemia; CML, Chronic myeloid leukemia; ET,essential thrombocythemia; L, Phenylalanine mustard; INF, interferon