Authors, year	Age /sex	Malignancies before MM	Treatment before MM	Malignancies-MM interval	SPE/IE	Treatment after MM	Outcome	Abnormal chro- -mosome/gene
Drasin H et al., 1979	50,F	Lung Lymphocytic lymphoma	Radiation therapy	9 years	IgG	MOP	Died after 28 months	NS
Claudia W et al., 1999	57,M	T-cell lymphoma	PUVA + INFa2b	2 years	IgG ?	alkeran+ decortin	Died after 28 months	NS
Muzaffer K et al., 2013	68 M	Colon adenocarcinoma gastrointestinal stromal tumor lung cancer	folinic acid 5-fl urouracil irinote can bevacizumab	15 months	IgG ?	Chemotherapy and biphosphomate	Died after 18 months	K-RAS mutation t(4;14),17p13,
Vassilia G. et al., 2005	68 M	CML	INF a Imatinib	18 months	IgG ?	MP + Imatinib	Alive after 8 months	t(9;14;22)(q34;q24;q11)
Francesc C et al., 1995	74 F	ET	INF a2b P32	61 months	IgA ?	MP	Died after 3 months	NS
Philip M et al., 1995	94 F	ET	Alkylating + thiotepa	11 years	IgA ?	MP	NA	NS
Montserral R et al., 1990	38 F	CNL	Without any therapy	7 years	?	MP	Alive after 5 months	46XX; Ph(-)
Michalis M et al., 2009	63 F	CML	Imatinib	65 months	IgA ?	TD + Imatinib VAD Velcode	Alive after two years	NS
Pérez LM et al., 2007	63 M	Prostate ade- -nocarcinoma	NA	NA	NA	NA	NA	NS
Rogulj IM et al., 2011	NA	CLL	NA	11 years		Without any therapy	NA	NS
Prósper F,et al, 1992	NA	ET	NA	5 years	NA	NA	NA	NS
Dorn GW et al., 1984	NA M	Hodgkin's disease	NA	NA	NA	NA	NA	NS
Tzilves D et al., 2007	74 M	gastrointestinal stromal tumor	Imatinib	1 month	IgA ?	MP + Imatinib	Died after 6 months	NS
Nowakowsk et al., 2007	65 M	Penile myeloid sarcoma	NA	NA	NA	NA	Died after 16 months	NS
Monique A, 2010	71 M	Merkel cell carcin- -oma CLL	RFC	14 years	?	CTX+P	Died after 6 months	NS
Hashimoto S et al., 1992	71 M	Diffuse large B cell malignant lymphoma	CHOP	32 months	IgA ?	Combination chemotherap	alive	NS
Derghazarian et al., 1974	65F	CML	busulphan	3 years	IgG ?	L	NA	46XX;.22q-; Ph (+)
Zoumbos et al., 1987	57M	CNL	busulphan	5 years	?	NA	NA	NS
Majhail NS et al., 2003	85 M	ET	hydroxyurea	50 months	IgG ?	Without any therapy	Refuse any treatment	NS
Majhail NS et al., 2003	54M	ET	Hydroxyurea	29 months	IgG ?	MP DOP	Died after 5 years	NS
Derghazarian C et al., 1974	65 F	ET	busulfan	7 years	IgG ?	Radiotherapy L + busulfan	Alive after 2 years	NS
Kough RH et al., 1978	75F	CLL	Chlorambucil	80 months	IgA?	MP CTX	Died after 3 year	NS
Kough RH et al., 1978	58 M	CLL	Chlorambucil	4 years	?	MP	Died after 1 year	NS

Table 1:Clinical data from cases of MM following other malignancies CTX, cyclophosphamide; L, Phenylalanine mustard; MP, melphalan + prednisone; TD,Thalidomide + dexamethasone; VAD vincristine + liposomal doxorubicin + dexamethasone; MOP, MP + Vincristine; DOP, vincristine + doxorubicin + dexamehasone; RFC, fludarabine + cyclophosphamide + rituxmab; CHOP doxorubicin + cyclophosphamide + vinscristine + rpednisolone; F, female; M, male; NA, not available; NS, not stated; SPE, serum protein electrophoresis; IE, immunoelectrophrosis; + combined with; - negative; ? increased; CNL, chronic neutrophilic leukaemia; CLL,chronic lymphocytic leukemia; CML, Chronic myeloid leukemia; ET,essential thrombocythemia; L, Phenylalanine mustard; INF, interferon