Figure 1 Bladder wall masses biopsy showing low-grade papillary transitional epithelium carcinoma, H-E ×100
Figure 2 A) Bone marrow aspirate smear demonstrating large numbers of plasma cells with eccentric round nucleus and condensed chromatin, some of plasmablast with basophilic cytoplasm. Wright-Giemsa. ×1000. B) Bone marrow trephine biopsy showing extensive infiltration of neoplastic plasma cells, H-E ×100
Authors, |
Age |
Malignancies before MM |
Treatment before MM |
Malignancies-MM interval |
SPE/IE |
Treatment after MM |
Outcome |
Abnormal chro- |
Drasin H |
50,F |
Lung Lymphocytic |
Radiation therapy |
9 years |
IgG |
MOP |
Died after |
NS |
Claudia W et al., 1999 |
57,M |
T-cell lymphoma |
PUVA + INFa2b |
2 years |
IgG |
alkeran+ decortin |
Died after |
NS |
Muzaffer K et al., 2013 |
68 M |
Colon adenocarcinoma gastrointestinal stromal tumor |
folinic acid 5-fl |
15 months |
IgG |
Chemotherapy and biphosphomate |
Died after |
K-RAS mutation |
Vassilia G. et al., 2005 |
68 M |
CML |
INF a |
18 months |
IgG |
MP + Imatinib |
Alive after 8 months |
t(9;14;22)(q34;q24;q11) |
Francesc C et al., 1995 |
74 F |
ET |
INF a2b |
61 months |
IgA |
MP |
Died after |
NS |
Philip M et al., 1995 |
94 F |
ET |
Alkylating + thiotepa |
11 years |
IgA |
MP |
NA |
NS |
Montserral R et al., 1990 |
38 F |
CNL |
Without any therapy |
7 years |
? |
MP |
Alive after 5 months |
46XX; Ph(-) |
Michalis M et al., 2009 |
63 F |
CML |
Imatinib |
65 months |
IgA |
TD + Imatinib |
Alive after two years |
NS |
Pérez LM et al., 2007 |
63 M |
Prostate ade- |
NA |
NA |
NA |
NA |
NA |
NS |
Rogulj IM et al., 2011 |
NA |
CLL |
NA |
11 years |
|
Without any therapy |
NA |
NS |
Prósper F,et al, 1992 |
NA |
ET |
NA |
5 years |
NA |
NA |
NA |
NS |
NA M |
Hodgkin's disease |
NA |
NA |
NA |
NA |
NA |
NS |
|
Tzilves D et al., 2007 |
74 M |
gastrointestinal stromal tumor |
Imatinib |
1 month |
IgA |
MP + Imatinib |
Died after |
NS |
Nowakowsk et al., 2007 |
65 M |
Penile myeloid sarcoma |
NA |
NA |
NA |
NA |
Died after |
NS |
Monique A, 2010 |
71 M |
Merkel cell carcin- |
RFC |
14 years |
? |
CTX+P |
Died after |
NS |
Hashimoto S et al., 1992 |
71 M |
Diffuse large B cell malignant lymphoma |
CHOP |
32 months |
IgA |
Combination chemotherap |
alive |
NS |
Derghazarian et al., 1974 |
65F |
CML |
busulphan |
3 years |
IgG |
L |
NA |
46XX;.22q-; |
Zoumbos et al., 1987 |
57M |
CNL |
busulphan |
5 years |
? |
NA |
NA |
NS |
Majhail NS |
85 M |
ET |
hydroxyurea |
50 months |
IgG |
Without any therapy |
Refuse any treatment |
NS |
Majhail NS et al., 2003 |
54M |
ET |
Hydroxyurea |
29 months |
IgG |
MP |
Died after 5 years |
NS |
Derghazarian C et al., 1974 |
65 F |
ET |
busulfan |
7 years |
IgG |
Radiotherapy |
Alive after 2 years |
NS |
Kough RH et al., 1978 |
75F |
CLL |
Chlorambucil |
80 months |
IgA? |
MP |
Died after 3 year |
NS |
Kough RH et al., 1978 |
58 M |
CLL |
Chlorambucil |
4 years |
? |
MP |
Died after 1 year |
NS |
Table 1:Clinical data from cases of MM following other malignancies CTX, cyclophosphamide; L, Phenylalanine mustard; MP, melphalan + prednisone; TD,Thalidomide + dexamethasone; VAD vincristine + liposomal doxorubicin + dexamethasone; MOP, MP + Vincristine; DOP, vincristine + doxorubicin + dexamehasone; RFC, fludarabine + cyclophosphamide + rituxmab; CHOP doxorubicin + cyclophosphamide + vinscristine + rpednisolone; F, female; M, male; NA, not available; NS, not stated; SPE, serum protein electrophoresis; IE, immunoelectrophrosis; + combined with; - negative; ? increased; CNL, chronic neutrophilic leukaemia; CLL,chronic lymphocytic leukemia; CML, Chronic myeloid leukemia; ET,essential thrombocythemia; L, Phenylalanine mustard; INF, interferon