Figure 1 the concept of sentinel lymph node.

Figure 2 Treatment Algorism For clinically negative neck.

The Study

Type of the study

No of cN0 patients

Type of diagnostic procedures

Type of management of neck

Recurrence Or failure

G.B Flach et al -2013 (7)

Retrospective

285

 USgFNAC

W&S =234
ND =51

W&S =65
ND =20

O'Connor R et al-2013 (8)

Prospective

481

SLNB

ND

12

P. W. Poeschl et al- 2012(9)

Retrospective

74

C.T-MRI

ND

13

Martin Canis et al;-2012(10)

Retrospective

425

C.T-MRI

W&S =223
ND =202

W&S =16
ND =10

Didier & Philippe -2011(11)

Prospective

21

C.T-MRI

ND

2

Bart M. Wensing et al-2011(12)

Retrospective

197

USgFNAC

W&S

48

David M. Montes et al -2011(13)

Retrospective

109

C.T-MRI

W&S= 61
ND= 48

W&S=9
ND=11

Civantos et al-2010(14)

prospective

140

C.T-MRI

ND

7

B.M Wensing et al-2010(15)

Retrospective

224

USgFNAC-US

ND

40

Yuen Apet al -2009(16)

Prospective

71

USgFNAC-US

W&S=35
MD=36

W&S=13
ND=2

M. Okura et al-2009(17)

Prospective

165

C.T-MRI

W&S=118
ND=47

W&S=25
ND=2

Keski-Säntti H et al-2008(18)

Prospective

13

SLNB

W&S=11
ND=2

0

Huang et al-2008(19)

Retrospective

380

C.T-MRI-US

W&S=556
ND=324

W&S=16
ND=40

E. M.Lype et al-2008(20)

Retrospective

161

C.T-MRI-US

ND=119
ND+RT=42

ND=11
ND+RT=9

Borgemeester MC et al-2008(21)

Retrospective

163

USgFNAC-US

W&S=37
ND=126

W&S=17
ND=21

Ana Capote et al-2007(22)

Retrospective

154

C.T-MRI-US

W&S=67
ND=87

W&S=18
ND=7

H. Keski et al-2006(23)

Retrospective

80

C.T-MRI-US

W&S=34
ND=46

W&S=15
ND=9

Ng et al-2006(24)

Prospective

134

C.T-MRI- [18F]FDG PET-CT

ND

0

Wensing et al- 2006(25)

Prospective

30

US followed by [18F]FDG PET-CT

ND

6

Robert D. Hart et al-2005(26)

Prospective

20

SLNB

ND

0

Alexandru & lidia -2004(27)

Retrospective

185

C.T-MRI

W&S= 154
ND=20
RT=11

W&S=99
RT=6

T. Poli et al-2003(28)

Prospective

10

SLNB

ND

0

Sato Eida et al-2003(29)

Prospective

58

Combination CT & US

W&S

17

Nieuwenhuis EJ et al-2002(30)

Prospective

161

USgFNAC

W&S

34

Rodeny J Taylor et al-2001(31)

Prospective

9

SLNB

ND

0

Shoaib T et al- 2001(32)

Prospective

40

SLNB

ND

0

Michiel W.M et al- 1999(33)

Prospective

77

USgFNAC

W&S

14

Table1 studies included in the current systematic review

Type of intervention

No. of the patients

Failure or recurrence

Neck dissection

2291

148

Wait and see policy

1523

406

Radiotherapy

11

6

Combined therapy

42

9

Sentinel lymph node biopsy

734

19

Ultrasonography-guided cytology (USgFNAC)

1107

236

Table2 Type of intervention, no. of patients and failure or recurrence in the studies included in the current systematic review.