Figure 1 A. Tumor growth curves in mice treated with oral RRX-001 alone. B. Tumor growth curves in mice treated with combination of oral RRx-001 and local tumor irradiation. C. Body weight of tumor-bearing mice treated with combination of oral RRx-001 and local tumor irradiation.

	Number	Number	4X TGT	TGD		P value (t-test)
	of mice	of death	(day)	(day)
	of mice	of death	(day)	(day)	Control	12mg/kg
					20mg/kg
Untreated Control	7		3.5 ± 0.6

12 mg/kg, QD x 5	6		4.9 ± 0.4	1.3 ± 0.4	<0.01

20 mg/kg, QOD x	7		4.9 ± 1.0	1.3 ± 1.0	0.01	1.0
3

60 mg/kg, one	7	2	5.0 ± 0.3	1.5 ± 0.3	<0.01	0.5	0.7
dose

A. Oral RRx-001 alone

	Number	4X TGT	TGD		P value (t-test)
	of mice	(day)	(day)
	of mice	(day)	(day)	Control	RRx-001
				Radiation
Untreated Control	7	3.0 ± 0.3

RRx-001 10mg/kg QD x 5	7	3.5 ± 0.4	0.5 ± 0.4	0.01

Radiation 250cGy daily x 5	7	3.9 ± 0.7	0.9 ± 0.7	0.01	0.3

RRx-001 + Radiation	7	6.1 ± 1.8	3.1 ± 1.8	<0.01	0.01	0.02

B. Combination of RRx-001 and radiation

Table 1: Tumor growth delay time of SCC VII tumors in mice