Figure 1 A. Tumor growth curves in mice treated with oral RRX-001 alone. B. Tumor growth curves in mice treated with combination of oral RRx-001 and local tumor irradiation. C. Body weight of tumor-bearing mice treated with combination of oral RRx-001 and local tumor irradiation.

 

Number

Number

4X TGT

TGD

 

P value (t-test)

 

 

of mice

of death

(day)

(day)

 

 

 

 

Control

12mg/kg

 

 

 

 

 

 

20mg/kg

 

 

Untreated Control

7

 

3.5 ± 0.6

 

 

 

 

 

 

 

 

 

 

 

 

12 mg/kg, QD x 5

6

 

4.9 ± 0.4

1.3 ± 0.4

<0.01

 

 

 

 

 

 

 

 

 

 

20 mg/kg, QOD x

7

 

4.9 ± 1.0

1.3 ± 1.0

0.01

1.0

 

3

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

60 mg/kg, one

7

2

5.0 ± 0.3

1.5 ± 0.3

<0.01

0.5

0.7

dose

 

 

 

 

 

 

 

A. Oral RRx-001 alone

 

Number

4X TGT

TGD

 

P value (t-test)

 

 

of mice

(day)

(day)

 

 

 

 

Control

RRx-001

 

 

 

 

 

Radiation

 

 

Untreated Control

7

3.0 ± 0.3

 

 

 

 

 

 

 

 

 

 

 

RRx-001 10mg/kg QD x 5

7

3.5 ± 0.4

0.5 ± 0.4

0.01

 

 

 

 

 

 

 

 

 

Radiation 250cGy daily x 5

7

3.9 ± 0.7

0.9 ± 0.7

0.01

0.3

 

 

 

 

 

 

 

 

RRx-001 + Radiation

7

6.1 ± 1.8

3.1 ± 1.8

<0.01

0.01

0.02

B. Combination of RRx-001 and radiation

Table 1: Tumor growth delay time of SCC VII tumors in mice