Authors & Year

Topic

Type of Study

Focused
Nutrients

Results

Findings

Shishir Ram
Shetty et
al, 2013 [18]

Role of Serum
Trace Elements
in Oral
Precancerous and
Oral Cancer – A Biochemical
Study.

Case control
study

Zinc, and Copper

Mean Copper
level was
significantly
higher in oral
sub mucous
fibrosis (310.61 + 4.22 μg/dL)
compared to
Control (196.54 + 3.76µg/dL).

Mean Zinc level (110.11 + 2.83µg/dL) was
significantly
lower in cases
compared to
Controls (162.07 +2.91µg/dL).

Copper - Zinc
ratio was found
to be higher (2.1 in OSMF, 1.32 in Oral Leucoplakia, 2.91 in Oral Squamous Cell Carcinoma) in the pre-cancer
and cancer
cases
compared to
Controls (1.21).

Authors & Year

Topic

Type of Study

Focused
Nutrients

Results

Findings

Amith Kumar et.al, 2014 [19]

Estimation of
Serum
Micronutrient
Levels and The
Possible Risk of Oral Cancer
and Pre-malignancy

Hospital Based
Case Control
Studies

Zinc, Copper,
Selenium,
Iron

1. Mean serum

level of Zinc (31.4±5.82 µg/gm Hb)
and Copper (109.76±25.58 µg/dL) was
significantly lower
(p<0.001) in oral cancer cases compared to
Controls (Zn: 35.6±6.25 µg/gm Hb And Cu: 180.9±5.48 µg/dL).

Mean serum level of
Selenium was
significantly higher
(p<0.001)
among Cancer cases (0.12 + 0.04 μg/dL)
compared to in
Controls. (0.10 + 0.01nμg/dL).

No Significant Difference found in Serum Fe level.

Zinc and
Copper was
found
protective for
Cancer.

Selenium was found to increase the
Risk.

No significant
effect was
found with
serum Iron
Level.

Authors & Year

Topic

Type of Study

Focused
Nutrients

Results

Findings

Preeti Singh et.al, 2005 [20].

Association
between
Breast Cancer
and Vitamin C,
Vitamin E and Selenium
Levels: Results
of a Case-
Control Study
in India

Hospital based
case control
study

Vitamin C,
Vitamin E
and Selenium

Mean serum
levels of
Vitamin C (0.68+0.45 mg/dL) and Vitamin E (0.92 + 0.68 mg/dL) in breast cancer patients are significantly lower than control.
For Vit C, the OR=0.16, 95% CI: 0.09 - 0.27.
And for Vit E the OR =0.23, 95% CI :
0.15 - 0.33).

No significant
difference was
found in the
mean serum
level of
Selenium.

84% and 77%
risk reduction
were observed
respectively
with Vitamin C and Vitamin E.

Selenium was
not found to
have a
significant
protective
effect.

Authors & Year

Topic

Type of Study

Focused
Nutrients

Results

Findings

Kapil U et al,
2003 [21].

Association of
Vitamin A,
Vitamin C and
Zinc with
Laryngeal
Cancer

Hospital based
case- control
study

Vitamin A,
Vitamin C
and Zinc

Maximum
cancer risk
reduction
(42%) was
found with
Vitamin C (OR= 0.58).

Risk
reduction
associated with
Vitamin A (2%) and Zinc (1%) were very
much lower.

Vitamin C,
Vitamin A and
Zinc were found to have
significant
protective
effect.

Authors & Year

Topic

Type of Study

Focused
Nutrients

Results

Findings

Madhuri K et al, 2011 [22].

Role of
Ascorbic Acid
as an
Antioxidant in
Gastric Cancer
Patients in
South Indian
Population

Hospital based
case control
study

Vitamin C

Total
chromosomal
aberrations as
well as sister
chromatid
exchange per
cell decreased
significantly
(t =9.39,
p <0.001)
in cases
following
3 months of
Vitamin C
prophylaxis.
No such
difference was
found in
controls.

Vitamin C
prophylaxis in
cancer patient
has a significant
effect in
reducing
chromosomal
aberrations.

Authors & Year

Topic

Type of Study

Focused
Nutrients

Results

Findings

Sunil Chandy et. al, 2008 [23].

Effect of
Vitamin B12
and Folate on
Homocysteine
levels in
Colorectal
Cancer

Case Control
study

Vitamin B12,
Folic acid

Mean folate
levels in cases
and controls
were 10.30 +
7.05 ng/mL and
10.53 + 3.99
ng/mL, respectively. (p=0.90).

Mean
Vitamin B12
levels were
419.76 +
281.70 pg/mL in cases and
239.41+
116.58 pg/mL in Controls
(p =0.014)

Vitamin B12
levels were
significantly
higher in cases.

No significant
difference in
folate level
between cases
and controls.