
Figure 1:Mutation profile of the cohort prior to osimertinib therapy (A), and at disease progression with osimertinib (B). The mutation profiles from the two time-points were also compared and depicted in (C). A-C. The patients were grouped according to baseline EGFR mutations 19del (green) or L858R (red) as indicated by the bar located at the bottom of the oncoprint. B–C. An annotation depicting the EGFR T790M status of each patient at progression, whether lost (blue) or retained (yellow) was also added at the bottom of the oncoprint. Each column represents a patient and each row represents a gene. Table on the left represents the mutation rate of each gene. Top plot represents the overall number of mutations a patient carried. Different colors denote different types of mutation.
Tables at a glance
Figures at a glance