No

Ad vector

Transgene

Cancer

Phase

Reference

1

Ad5-SGE REIC/Dkk3

REIC/Dkks

Localized Prostate cancer

I/II

123

2

Ad5-PSA

PSA

Prostate cancer; recurrent/hormone refractory prostate cancer

I/II

113, 114

3.

Advexin (rAd-p53)

P53

squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, and larynx; colorectal cancer, HCC, NSCLC, prostate cancer, breast cancer, ovarian cancer, bladder cancer, glioma, and squamous cell carcinoma of the head and neck

I/II

39, 108

4.

Adv/tk (GMCI)

HSV-tk

Advanced non-metastatic pancreatic adenocarcinoma II

II

NCT02446093

5.

Ad5-yCD/ mutTKSR39rep-hIL-12

Cytosine deaminase, HSV-tK, hIL-12

metastatic Prostate cancer

I

NCT03281382

6.

Ad5-SGE REIC/Dk3 (MTG201)

REIC/Dkk3

Relapsed malignant pleural mesothelioma

II

124

No

Ad vector

Transgene

Cancer

Phase

Reference

7

AdHSV-tk /GCV

HSV-tk Ad- hCMV- Flt3L

High-grade malignant gliomas

I/II

125

8

ETBX-011

CEA

Metastatic colorectal cancer

I/II

109, 110, 126

9

Adv/tk

HSV-tk

Advanced hepatocellular carcinoma

III

127

10

SCH-58500

P53

Primary ovarian cancer, fallopian cancer and peritoneal cancer

I

128

11

ONCOS-102

GM-CSF

Melanoma

I

64

12

Adv-tk (GMCI)

Adv-tk

Pediatric brain tumors

I

129

13

Ad-MAGEA3

MAGE-A3

Advanced/Met., MAGE-A3+ Solid Tumors, NSCLC

I/II

NCT02285816

14

rAd-IFN/Syn-3 (instiladrin)

INFα-2b

High grade non-muscle invasive bladder cancer

III

130

15

Ad-RTS-hIL-12

IL-12

Glioblastoma or malignant glioma; Advanced or metastatic breast cancer; recurrent or progressive melanoma

I

131

No

Ad vector

Transgene

Cancer

Phase

Reference

16

Ad-E6E7 and MG1-E6E7

HPV E6/E7

HPV-associated cancer

I

117

17

TILT-123

hTNF-α, hIL-2

Advanced melanoma

I

66

18

ADV/RSV-TK

HSV-TK

prostate cancer; glioma, retinoblastoma, mesothelioma

I

86-88

18

BG00001

INF-β

Pleural melanoma

I

87

20

LOAd703

CD40L, 4-1BBL

Pancreatic cancer, bacillary cancer, collateral cancer

I/II

NCT03225989

21

Adv/HSV-tk

HSV-tk

Metastatic non-small cell lung carcinoma and uveal melanoma

II

NCT02831933

22

DNX-2440

OX40L

Glioblastoma

I

NCT03714334

23

Ad/PNP+ fludarabine

PNP

Head and neck squamous cell carcinoma

1

132

24

DNX-2401

Recurrent glioma

II

NCT02798406

No

Ad vector

Transgene

Cancer

Phase

Reference

25

Oncorine or H101

head and neck cancer

III

39

26

Ad-MAGEA3

MAGE-A3

NSCLC

I/II

NCT02879760

27

Gendicine (rAd-p53)

P53

head and neck squamous cell carcinoma, malignant glioma, HCC, NSCLC and epithelial ovarian carcinoma

III

133; 134

28

ONYX-015

Advanced cancer

Preclinical trail

52

29

ETBX-011, ETBX-061, and ETBX-051 (Tri-Ad vaccine)

TAA

Advanced cancer

I

111

30

ChAdOx1–MVA

STEAP1

Prostate cancer

Preclinical

118

31

Ad5-yCD/ mutTKSR39rep-hIL-12

Cytosine deaminase, HSV-tK, IL-12

Prostate cancer

I

NCT02555397

32

Ad-IFN/Syn 3

INF-α

Bladder cancer

Preclinical trail

61