1Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, et al. (2010) Executive Summary: Heart Disease and Stroke Statistics--2010 Update: A Report From the American Heart Association. Circulation 121: 948-954.
2 Eisner DA, Isenberg G, Sipido KR (2003) Normal and Pathological Excitation- Contraction Coupling in the Heart -- an Overview. J Physiol 546: 03-04.
3 Baartscheer A, van Borren MMGJ (2008) Sodium Ion Transporters as New Therapeutic Targets in Heart Failure. Cardiovasc Hematol Agents Med Chem 6: 229-236.
4 Murphy E, Eisner DA (2009) Regulation of Intracellular and Mitochondrial Sodium in Health and Disease. Circ Res 104: 292-303
5 Despa S, Islam MA, Weber CR, Pogwizd SM, Bers DM (2002) Intracellular Na(+) Concentration is Elevated in Heart Failure but Na/K Pump Function is Unchanged. Circulation 105: 2543-2548.
6 Baartscheer A, Schumacher CA, van Borren MMGJ, Belterman CNW, Coronel R, et al. (2003) Increased Na+/H+-Exchange Activity is the Cause of Increased [Na+]i and Underlies Disturbed Calcium Handling in the Rabbit Pressure and Volume Overload Heart Failure Model. Cardiovasc Res 57: 1015-1024.
7 Pieske B, Houser SR (2003) [Na+]i Handling in the Failing Human Heart. Cardiovasc Res 57: 874-886.
8 Engelhardt S, Hein L, Keller U, Klämbt K, Lohse MJ (2002) Inhibition of Na(+)-H(+) Exchange Prevents Hypertrophy, Fibrosis, and Heart Failure in Beta(1)- Adrenergic Receptor Transgenic Mice. Circ Res 90: 814-819.
9 Chen L, Chen CX, Gan XT, Beier N, Scholz W, et al. (2004) Inhibition and Reversal of Myocardial Infarction-Induced Hypertrophy and Heart Failure by NHE-1 Inhibition. Am J Physiol Heart Circ Physiol 286: 381-387.
10 Marano G, Vergari A, Catalano L, Gaudi S, Palazzesi S, et al. (2004) Na+/ H+ Exchange Inhibition Attenuates Left Ventricular Remodeling and Preserves Systolic Function in Pressure-Overloaded Hearts. Br J Pharmacol 141: 526-532.
11 Baartscheer A, Schumacher CA, van Borren MMGJ, Belterman CNW, Coronel R, et al. (2005) Chronic Inhibition of Na+/H+-Exchanger Attenuates Cardiac Hypertrophy and Prevents Cellular Remodeling in Heart Failure. Cardiovasc Res 65: 83-92.
12 Cingolani HE, Ennis IL (2007) Sodium-hydrogen exchanger, cardiac overload, and myocardial hypertrophy. Circulation 115: 1090-1100.
13 Huber JD, Bentzien J, Boyer SJ, Burke J, DeLombaert S, et al. (2012) Identification of a potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor with a suitable profile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat. J Med Chem 55: 7114-7140.
14 Goldman S, Raya TE (1995) Rat Infarct Model of Myocardial Infarction and Heart Failure. J Card Fail 1: 169-177.
15 Gaballa MA, Goldman S (2002) Ventricular Remodeling in Heart Failure. J Card Fail. 8: 476-485.
16 16) Pfeffer MA, Pfeffer JM, Steinberg C, Finn P (1985) Survival After Experimental Myocardial Infarction: Beneficial Effects of Long-Term Therapy with Captopril. Circulation 72: 406-412.
17 Raya TE, Gay RG, Aguirre M, Goldman S (1989) Importance of Venodilatation in Prevention of Left Ventricular Dilatation after Chronic Large Myocardial Infarction in Rats: A Comparison of Captopril and Hydralazine. Circ Res 64: 330-337.
18 Gaballa MA, Raya TE, Goldman S (1995) Large Artery Remodeling After Myocardial Infarction. Am J Physiol 268: 2092-2103.
19 Raya TE, Gaballa M, Anderson P, Goldman S (1997) Left Ventricular Function and Remodeling after Myocardial Infarction in Aging Rats. Am J Physiol 273: 2652-2658.
20 Thai H, Castellano L, Juneman E, Phan H, Do R, et al. (2006) Pretreatment with Angiotensin Receptor Blockade Prevents Left Ventricular Dysfunction and Blunts Left Ventricular Remodeling Associated with Acute Myocardial Infarction. Circulation 114: 1933-1939.
21 Thai HM, Juneman E, Lancaster J, Hagerty T, Do R, et al. (2009) Implantation of a Three-Dimensional Fibroblast Matrix Improves Left Ventricular Function and Blood Flow After Acute Myocardial Infarction. Cell Transplant 18: 283-295.
22 Lancaster JL, Juneman E, Hagerty T, Do R, Hicks M, et al. (2010) Viable Fibroblast Matrix Patch Induces Angiogenesis and Increases Myocardial Blood Flow in Heart Failure after Myocardial Infarction. Tissue Eng.Part A 16: 3065-3073.
23 Pennock GD, Raya TE, Bahl JJ, Goldman S, Morkin E (1993) Combination Treatment with Captopril and the Thyroid Hormone Analogue 3,5- Diiodothyropropionic Acid. A New Approach to Improving Left Ventricular Performance in Heart Failure. Circulation 88: 1289-1298.
24 Karmazyn M, Sawyer M, Fliegel L (2005) The Na(+)/H(+) Exchanger: A Target for Cardiac Therapeutic Intervention. Curr Drug Targets Cardiovasc Haematol Disord 5: 323-335.
25 Takewaki S, Kuro-o M, Hiroi Y, Yamazaki T, Noguchi T, et al. (1995) Activation of Na(+)-H+ Antiporter (NHE-1) Gene Expression During Growth, Hypertrophy and Proliferation of the Rabbit Cardiovascular System. J Mol Cell Cardiol 1995, 27: 729-742.
26 Avkiran M, Haworth RS (2003) Regulatory Effects of G Protein-Coupled Receptors on Cardiac Sarcolemmal Na+/H+ Exchanger Activity: Signalling and Significance. Cardiovasc. Res 57: 942-952.
27 Dulce RA, Hurtado C, Ennis IL, Garciarena CD, Alvarez MC, et al. (2006) Endothelin-1 Induced Hypertrophic Effect in Neonatal Rat Cardiomyocytes: Involvement of Na+/H+ and Na+/Ca2+ Exchangers. J Mol Cell Cardiol 41: 807-815.
28 Spitznagel H, Chung O, Xia Q, Rossius B, Illner S, et al. (2000) Cardioprotective Effects of the Na(+)/H(+)- Exchange Inhibitor Cariporide in Infarct- Induced Heart Failure. Cardiovasc Res 46: 102-110.