GROUPS |
BWT |
RV |
LV |
LV |
MAP |
Tau |
HR |
SYS |
LV EDP |
LV +dP/dt |
LV -dP/dt |
Dead Volume |
LV PDP (mmHg) |
Sham N = 8 |
378±18 | 0.18±0.10 | 0.80±.04 | 0.2±0.1 | 119±3 | 13.9±1.5 | 275±15 | 136±3 | 7±1 | 8138±426 | 6769±468 | 0.19±0.02 | 186±7 |
LVD N = 4 |
360±13 | 0.22±0.03 | 0.80±.02 | 0.2±0.1 | 118±8 | 18.2±0.7 | 252±17 | 136±8 | 8±1 | 6789±467 | 5067±591 | 0.21±0.04 | 163±10 |
CHF N = 10 |
350±9 | 0.41±0.03* | 0.78±0.03 | 0.2±0.1 | 99±3* | 24.2±1.4* | 243±8 | 110±3* | 26±1* | 4890±193* | 3073±142* | 0.29±0.03* | 118±3* |
Sham NHE-1 1.0 mg/kg N = 6 |
359±5 | 0.19±0.03 | 0.76±0.02 | 0.2±0.0 | 119±1 | 13.6±1.2 | 292±13 | 136±3 | 5±1 | 8337±430 | 7205±550 | 0.14±0.01 | 178±16 |
LVD NHE-1 1.0 mg/kg N = 7 |
361±9 | 0.20±0.02 | 0.80±0.03 | 0.2±0.0 | 116±2 | 20.2±1.5 | 266±7 | 132±3 | 10±2 | 6404±256 | 4664±316 | 0.20±0.01 | 154±9 |
CHF NHE-1 1.0 mg/kg N = 9 |
360±9 | 0.38±0.01 | 0.72±0.03 | 0.2±0.0 | 95±4 | 23.0±1.0 | 237±4 | 108±5 | 23±1 | 5014±184 | 3099±112 | 0.22±0.02 | 123±3 |
Sham NHE-1 3 mg/kg N = 11 |
372±7 | 0.23±0.12 | 0.82±0.10 | 0.2±0.0 | 119±3 | 13.8±0.6 | 275±9 | 129±4 | 5±1 | 7938±362 | 6745±288 | 0.15±0.02 | 197±6 |
LVD NHE-1 3.0 mg/kg N = 7 |
368±7 | 0.24±0.01 | 0.85±0.03 | 0.2±0.0 | 106±3 | 18.5±1.5 | 273±13 | 121±4 | 9±1 | 6248±285 | 4604±272 | 0.24±0.03 | 161±2 |
CHF NHE-1 3.0 mg/kg N = 9 |
345±8 | 0.36±0.03 | 0.80±0.05 | 0.2±0.0 | 100±4 | 24.1±0.9 | 246±9 | 104±10 | 23±2 | 5069±260 | 3288±204 | 0.27±0.01 | 119±7 |
Body weight (BWT); right ventricular weight (RV); left ventricular weight (LV); LV/body weight ratio (LV WT/BW); left ventricular dysfunction
(LVD); mean arterial pressure (MAP); heart rate (HR); LV end-diastolic pressure (EDP); LV peak developed pressure (LV PDP)
*P< 0.05 Sham versus Severe CHF
>Table 1: In Vivo Hemodynamic Measurements
Figure 1: Ejection fraction in CHF rats. Baseline (N=36), 6wk control (N=6), 6wk 0.3mg (N=9), 6wk 1mg (N=10), 6wk 3mg (N=13). Data are mean + SE. * denotes statistical significance between baseline and all other groups (P < 0.05). ** denotes statistical significance for intergroup comparison (P < 0.05).
Figure 2: LV diastolic diameter in CHF rats. Baseline (N=36), 6wk control (N=6), 6wk 0.3mg (N=9), 6wk 1mg (N=10), 6wk 3mg (N=13). Data are mean + SE. * denotes statistical significance between baseline and all other groups (P < 0.05). ** denotes statistical significance for intergroup comparison (P < 0.05).
Figure 3: LV systolic diameter in CHF rats. Baseline (N=36), 6wk control (N=6), 6wk 0.3mg (N=9), 6wk 1mg (N=10), 6wk 3mg (N=13). Data are mean + SE. * denotes statistical significance between baseline and all other groups (P < 0.05). ** denotes statistical significance for intergroup comparison (P < 0.05).
Figure 1: Ejection fraction in CHF rats. Baseline (N=36), 6wk control (N=6), 6wk 0.3mg (N=9), 6wk 1mg (N=10), 6wk 3mg (N=13). Data are mean + SE. * denotes statistical significance between baseline and all other groups (P < 0.05). ** denotes statistical significance for intergroup comparison (P < 0.05).
Figure 2: LV diastolic diameter in CHF rats. Baseline (N=36), 6wk control (N=6), 6wk 0.3mg (N=9), 6wk 1mg (N=10), 6wk 3mg (N=13). Data are mean + SE. * denotes statistical significance between baseline and all other groups (P < 0.05). ** denotes statistical significance for intergroup comparison (P < 0.05).
Figure 3: LV systolic diameter in CHF rats. Baseline (N=36), 6wk control (N=6), 6wk 0.3mg (N=9), 6wk 1mg (N=10), 6wk 3mg (N=13). Data are mean + SE. * denotes statistical significance between baseline and all other groups (P < 0.05). ** denotes statistical significance for intergroup comparison (P < 0.05).