Figure 1:
FIGURE 1
|
|
GROUP-1 NSTEMI |
GROUP-2 STEMI |
p-VALUE |
|
|
AGE |
>50 |
15 (25 ) |
24(40) |
0.07 |
|
<50 |
45(75) |
36(60) |
||
|
SEX |
MALE |
49(64.83) |
44(73.33) |
0.172 |
|
FEMALE |
11(35.17) |
16(26.67) |
||
|
SMOKING |
NON SMOKER |
22(36.66) |
28(46.66) |
0.465 |
|
SMOKER |
28(63.34) |
32(53.34) |
||
|
ALCOHOL |
NON -ALCOHOL |
48(80) |
38(73.65) |
0.043 |
|
ALCOHOL |
12(20) |
22(26.35) |
||
|
PHYSICAL ACTIVITY |
REGULAR |
15(25) |
11(18.33) |
0.375 |
|
INTERMITTENT |
45(75) |
49(81.66) |
||
|
WEIGHT (kgs) |
<50 |
13(21.66) |
11(18.33) |
|
|
>50 |
47(78.33) |
49(51.04) |
||
|
Diabetus mellitus(DM) |
NO |
45(75.00) |
45(75.00) |
1.000 |
|
YES |
15(25.0) |
15(25.0) |
||
|
Blood pressure (BP) |
90- 130 |
30(50.0) |
36(60.0) |
0.197 |
|
>130 |
30(50.0) |
22(36.6) |
||
|
<90 |
0(0.00) |
1(1.66) |
||
|
Killip class |
NO CLASS |
1(1.66) |
2(3.33) |
0.275 |
|
CLASS 1 |
28(46.6) |
39(65.0) |
||
|
CLASS 2 |
14(23.3) |
8(13.33) |
||
|
CLASS 3 |
8(13.33) |
5(8.33) |
||
|
CLASS 4 |
9(15.0 ) |
6(1.0) |
||
|
Congestive heart Failure (CHF) |
NO |
41(68.33) |
43(71.66) |
0.690 |
|
YES |
19(31.66) |
17(28.33) |
||
|
Hemoglobin (gm/dl) |
>9 |
57(95.0) |
60(100.0) |
0.122 |
|
<9 |
3(5.00) |
0(0.00) |
||
|
Hematocrit (%) |
41-53 |
18(30.0) |
22(36.66) |
0.439 |
|
1>53 |
42(70.0) |
38(63.33) |
||
|
Platelet count (Lakh/mi- |
<1.5 |
48(80.00) |
52(86.66) |
0.327 |
|
>4.5 |
12(20.00) |
8(13.33) |
||
|
Total leucocyte count (cells/cumm) |
10000 |
48(80.0) |
42(70) |
0.386 |
|
>10000 |
10(16.66) |
17(28.33) |
||
|
<4000 |
2(3.33) |
1(1.66) |
||
|
ESR (mm/hr) |
MALE<17, FEMALE<25 |
16(26.66) |
35(58.33) |
0.000 |
|
MALE>17, FEMALE>25 |
44(73.33) |
25(41.66) |
||
|
Glucose (mg/dL) |
UPTO 140 |
51(85.0) |
50(83.33) |
0.636 |
|
>140 |
9(15) |
10(16.66) |
||
|
Dyslipidemia |
NO |
36(60) |
35(58.33) |
0.853 |
|
YES |
24(40) |
25(41.66) |
||
|
CRP (µg/ml) |
UPTO 3 |
28(46.66) |
31(51.66) |
0.584 |
|
>3 |
32(53.33) |
29(48.33) |
||
|
Troponin-I |
NEGATIVE |
39(65.0) |
34(56.66) |
0.453 |
|
POSITIVE |
21(35.0) |
25(43.33) |
||
|
Creatinine Kinase (CK) |
|
43(71.66) |
26(43.33) |
0.002 |
|
|
17(28.33) |
34(56.66) |
||
|
Creatinine Kinase-MB (U/L) |
8.5(0.1-267) |
8(0.8-414) |
0.637 |
|
|
Coagulopathy |
NO |
58(96.66) |
52(86.66) |
0.047 |
|
YES |
2(3.33) |
8(13.33) |
||
|
Site of infarction |
ANTERIOR |
33(55.0) |
33(55.00) |
1.000 |
|
Coagulopathy |
26(43.33) |
25(41.66) |
||
|
POSTERIOR |
1(1.66) |
2(3.33) |
||
Table 1: Baseline of physical, clinical and laboratory characteristics of Study participants
|
CYTOKINE |
GROUP 1` STEMI (Min-Max) |
GROUP 2 NSTEMI (Min-Max) |
GROUP 3 CONTROLS (Min-Max) |
P –VALUE OVERALL |
1 VS 2 |
1 VS 3 |
2VS3 |
|
IL 6 -day 0 |
5.16 (0- 304.48) |
1.07 (0 - 261.87 ) |
0.30 (0 -10.83) |
0.0001 |
0.0026 |
0.0000 |
0.0145 |
|
IL 6- day 3 |
8.26 (0-324.05) |
1.14 (0 -412.46) |
0.30 (0 -10.83) |
0.0001 |
0.0005 |
0.0000 |
0.0152 |
|
P VALUE |
0.123 |
0.513 |
--- |
--- |
--- |
--- |
--- |
|
IL 10 -day 0 |
1.87 (0- 143.05) |
1.84 (0 -243.80) |
1.42 (0 -189.16) |
0.8157 |
---- |
--- |
--- |
|
IL10 –day 3 |
2.96 (0 -143.57) |
2.18 (0 -64.70) |
1.42 (0 -189.16) |
0.1032 |
--- |
--- |
--- |
|
P VALUE |
0.000 |
0.485 |
--- |
--- |
--- |
--- |
--- |
|
IL 18 –day 0 |
434.95 ( 2 3 . 9 3 |
263.08 (0 - 4872.10) |
46.51 ( 0 - 495.81) |
0.0001 |
0.8604 |
0.0000 |
0.0000 |
|
IL 18- day 3 |
123.73 (0-1935.11) |
108.40 (0-3763.62) |
46.51 ( 0 - 495.81) |
0.0005 |
0.1538 |
0.0025 |
0.0005 |
|
P VALUE |
0.000 |
0.002 |
--- |
---- |
---- |
---- |
---- |
|
TNF alpha |
33.48 ( 0 - 98.89 ) |
60.68 (0 - 634.43) |
6.37 ( 0 -866.86) |
0.0001 |
0.0000 |
0.0000 |
0.0000 |
|
TNF al- pha-day 3 |
33.48 (9.41 - |
43.53 (6.61 - |
6.37 (0 -866.86) |
0.0001 |
0.0212 |
0.0000 |
0.0000 |
|
P VALUE |
0.6540 |
0.0088 |
----- |
---- |
----- |
---- |
---- |
Table 2: Correlation of cytokines IL6, IL10, IL18 and TNF alpha among groups of STEMI, NSTEMI and controls on day 0 and day 3 of admission
Figure 1:
Figure 2:
Tables at a glance
Figures at a glance