|
Control |
COPD |
p Value |
GSH (U/ml) |
0.159±0.47 |
0.024±0.013 |
<0.001* |
MDA (nmol/ml) |
0.179±0.057 |
0.871±0.265 |
<0.001* |
Hb (g/dl) |
14.76±1.50 |
15.42±1.75 |
0.124 |
Hct (%) |
44.38±4.51 |
48.06±6.09 |
0.010* |
LDL (mg/dL) |
109.40±31.08 |
98.97±38.22 |
0.251 |
TG (mg/dL) |
116.77±81.12 |
126.63±56.92 |
0.588 |
HDL (mg/dL) |
45.77±10.80 |
39.20±7.50 |
0.009* |
Cholesterol (mg/dL) |
178.73±41.25 |
163.23±45.67 |
0.173 |
D-dimer (µg/l) |
152.93±95.29 |
228.70±216.63 |
0.087 |
EF (%) |
64.07±4.81 |
60.27±4.07 |
0.002* |
O2 saturation (%) |
96.97±1.67 |
83.60±5.44 |
<0.001* |
CAT† (U/ml) |
0.002-0.002 |
0.0004-0.000 |
<0.001* |
CRP† (mg/l) |
0.400-0.388 |
0.670-0.648 |
<0.001* |
Table 1. Overview of parameters under investigation in COPD patients and the control group.
(Abbreviations: COPD: chronic obstructive pulmonary disease; GSH: glutathione peroxidase; MDA: malondialdehyde; Hb: hemoglobin; Hct: hematocrit; LDL: low-density lipoproteins; TG: triglycerides; HDL: high-density lipoproteins; EF: ejection fraction; CAT: catalase; CRP: C-reactive protein; *: statistically significant; †: expressed as median-interquartile range)
|
PHT (-) |
PHT (+) |
p Value |
GSH (U/ml) |
0.023-0.008 |
0.022-0.015 |
0.385 |
MDA (nmol/ml) |
0.769-0.613 |
0.801-0.265 |
0.362 |
Hb (g/dl) |
15.35-1.10 |
15.80±3.35 |
0.539 |
Hct (%) |
47.45-5.92 |
49.45-11.80 |
0.672 |
LDL (mg/dL) |
124.00-39.50 |
85.50-62.25 |
0.046* |
TG (mg/dL) |
152.00-119.75 |
105.00-64.50 |
0.038* |
HDL (mg/dL) |
40.50-10.25 |
43.00-12.50 |
0.298 |
Cholesterol (mg/dL) |
193.00-52.25 |
160.00-53.25 |
0.117 |
D-dimer (µg/l) |
167.00-156.00 |
140.00-213.00 |
0.882 |
EF (%) |
60.00-7.50 |
60.00-6.25 |
0.687 |
O2 saturation (%) |
86.00-5.25 |
82.00-9.00 |
0.089 |
CAT (U/ml) |
0.0004-0.0003 |
0.0004-0.0004 |
0.866 |
CRP (mg/l) |
0.67-0.66 |
0.67-0.70 |
0.799 |
Table 2. Comparison of COPD patients with and without PHT†.
(Abbreviations: COPD: chronic obstructive pulmonary disease; GSH: glutathione peroxidase; MDA: malondialdehyde; Hb: hemoglobin; Hct: hematocrit; LDL: low-density lipoproteins; TG: triglycerides; HDL: high-density lipoproteins; EF: ejection fraction; CAT: catalase; CRP: C-reactive protein; *: statistically significant)
†: All data have been expressed as a median-interquartile range.
Variable |
Correlate |
p Value |
r |
Age |
MDA |
0.032 |
0.282 |
GSH |
MDA |
0.001 |
-0.418 |
TG |
0.004 |
0.375 |
|
MDA |
EF |
0.025 |
-0.293 |
O2 saturation |
<0.001 |
-0.536 |
|
Hct |
HDL |
0.019 |
-0.307 |
LDL |
TG |
0.005 |
0.361 |
Cholesterol |
<0.001 |
-0.536 |
|
TG |
HDL |
0.032 |
-0.282 |
Cholesterol |
<0.001 |
0.514 |
|
Cholesterol |
CRP |
0.012 |
-0.327 |
CRP |
EF |
0.002 |
-0.392 |
D-dimer |
O2 saturation |
0.022 |
-0.301 |
Table 3. Correlation of biochemical, inflammatory and cardiorespiratory variables in the whole study population.
(Abbreviations: GSH: glutathione peroxidase; MDA: malondialdehyde; Hct: hematocrit; LDL: low-density lipoproteins; TG: triglycerides; HDL: high-density lipoproteins; EF: ejection fraction; CRP: C-reactive protein; *: statistically significant)