
Figure 1: A flow chart of the study selection process
Variables |
All subjects |
Age, years |
63 ± 6 |
Male, n (%) |
229,927 (43%) |
Suita score |
46 ± 10 |
Framingham risk score |
6.6 ± 2.9 |
BMI, kg/m2 |
23.5 ± 3.4 |
Waist circumference, cm |
84 ± 9 |
Hypertension, n (%) |
231,126 (43%) |
Systolic BP, mmHg |
129 ± 16 |
Diastolic BP, mmHg |
76 ± 11 |
Dyslipidemia, n (%) |
298,946 (56%) |
Diabetes mellitus, n (%) |
62,189 (12%) |
Smoking, n (%) |
82,391 (15%) |
Biochemical data |
|
eGFR, ml/min/1.73m2 |
76 ± 17 |
HbA1c, % |
5.4 ± 0.7 |
FBS, mg/dL |
98 ± 21 |
Total cholesterol, mg/dL |
211 ± 35 |
Triglyceride, mg/dL |
125 ± 89 |
HDL-C, mg/dL |
61 ± 15 |
LDL-C, mg/dL |
125 ± 30 |
Proteinuria, n (%) |
31,498 (6%) |
CKD, n (%) |
98,816 (18%) |
Medications |
|
Anti-hypertensive drug, n (%) |
159,140 (30%) |
Anti-diabetic drug, n (%) |
29,307 (5%) |
Anti-dyslipidemia drug, n (%) |
79,149 (15%) |
Table 1:Baseline characteristic of all subjects.
Data are expressed as mean ± SD, number (percentage). BMI, body mass index; BP, blood pressure; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; FBS, fasting blood sugar; HbA1c, glycosylated hemoglobin A1c; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol.
Variables |
Low Suita score |
High Suita score |
P value |
Age, years |
62 ± 9 |
69 ± 4 |
<0.0001 |
Male, n (%) |
154,752 (29%) |
75175 (87%) |
<0.0001 |
Framingham risk score |
6.0 ± 3.6 |
9.9 ± 2.4 |
<0.0001 |
BMI, kg/m2 |
23.2 ± 3.5 |
24.5 ± 3.2 |
<0.0001 |
Waist circumference, cm |
84 ± 10 |
88 ± 8 |
<0.0001 |
Hypertension, n (%) |
166,153 (37%) |
64,973 (75%) |
<0.0001 |
Systolic BP, mmHg |
127 ± 17 |
139 ± 18 |
<0.0001 |
Diastolic BP, mmHg |
76 ± 11 |
80 ± 11 |
<0.0001 |
Dyslipidemia, n (%) |
237,225 (53%) |
61,721 (72%) |
<0.0001 |
Diabetes mellitus, n (%) |
33,075 (7.4%) |
29,114 (34%) |
<0.0001 |
Smoking, n (%) |
56,385 (13%) |
26,006 (30%) |
<0.0001 |
Biochemical data |
|
|
|
eGFR, ml/min/1.73m2 |
77 ± 17 |
68 ± 18 |
<0.0001 |
HbA1c, % |
5.3 ± 0.6 |
5.8 ± 1.0 |
<0.0001 |
FBS, mg/dL |
96 ± 18 |
110 ± 31 |
<0.0001 |
Total cholesterol, mg/dL |
211 ± 36 |
216 ± 37 |
<0.0001 |
Triglyceride, mg/dL |
121 ± 89 |
148 ± 94 |
<0.0001 |
HDL-C, mg/dL |
63 ± 16 |
53 ± 14 |
<0.0001 |
LDL-C, mg/dL |
123 ± 31 |
134 ± 32 |
<0.0001 |
Proteinuria, n (%) |
20,381 (4.6%) |
11,117 (13%) |
<0.0001 |
CKD, n (%) |
64,008 (14%) |
34,808 (40%) |
<0.0001 |
Medications |
|
|
|
Anti-hypertensive drug, n (%) |
113,247 (25%) |
45,893 (53%) |
<0.0001 |
Anti-diabetic drug, n (%) |
15,425 (3.4%) |
13,882 (16%) |
<0.0001 |
Anti-dyslipidemia drug, n (%) |
65,270 (15%) |
13,879 (16%) |
<0.0001 |
Table 2: Comparison of clinical characteristics between subjects with high and low Suita score.
Data are expressed as mean ± SD, number (percentage). BMI, body mass index; BP, blood pressure; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; FBS, fasting blood sugar; HbA1c, glycosylated hemoglobin A1c; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol.
|
Univariate analysis |
||
Variables |
HR |
95%CI |
P value |
Aortic aneurysm rupture deaths |
|
|
|
Suita score* |
4.605 |
3.281-6.466 |
<0.0001 |
Framingham risk score* |
1.926 |
1.496-2.481 |
<0.0001 |
Waist circumference |
1.046 |
1.016-1.077 |
0.0021 |
Alcohol consumption |
2.094 |
1.093-4.011 |
0.0220 |
Aortic dissection deaths |
|
|
|
Suita score* |
1.989 |
1.558-2.539 |
<0.0001 |
Framingham risk score* |
1.278 |
1.068-1.527 |
0.0067 |
Waist circumference |
1.037 |
1.014-1.058 |
0.0009 |
Alcohol consumption |
1.067 |
0.680-1.674 |
0.7760 |
Table 3: Univariate Cox proportional hazard analyses of predicting aortic aneurysm rupture and aortic dissection deaths.
*Per 1-SD increase. CI, confidence interval; HR, hazard ratio.
|
Multivariate analysis |
||
Variables |
HR |
95%CI |
P value |
Aortic aneurysm rupture deaths |
|
|
|
Suita score* |
4.342‡ |
3.014-6.257 |
<0.0001 |
Suita score* |
3.792# |
2.564-5.609 |
<0.0001 |
Framingham risk score* |
1.922‡ |
1.450-2.547 |
<0.0001 |
Framingham risk score* |
1.823# |
1.367-2.431 |
<0.0001 |
Aortic dissection deaths |
|
|
|
Suita score* |
1.992‡ |
1.524-2.602 |
<0.0001 |
Suita score* |
1.705# |
1.289-2.255 |
0.0002 |
Framingham risk score* |
1.228‡ |
1.006-1.498 |
0.0433 |
Framingham risk score* |
1.164# |
0.950-1.427 |
0.1416 |
Table 4: Multivariate Cox proportional hazard analyses of predicting aortic aneurysm rupture and aortic dissection deaths.
* Per 1-SD increase. ‡after adjustment for waist circumference and alcohol consumption. #after adjustment for waist circumference, alcohol consumption and chronic kidney disease. CI, confidence interval; HR, hazard ratio.
Figure 1: A flow chart of the study selection process
Figure 2: Kaplan–Meier analysis of deaths of ischemic heart disease (A), aortic aneurysm rupture (B), and aortic dissection (C) for subjects with a high and low Suita score.
Figure 3: Comparisons of receiver operating characteristic curve analyses of deaths of ischemic heart disease (A), aortic aneurysm rupture (B), and aortic dissection (C) between the Suita score and the Framingham risk score.
Tables at a glance
Figures at a glance