NM	Manufacturer	Size	Suspended media	Aerosol generation method	Exposure route	Reference
AgNP	NANATECH Co, Korea	60 nm (52.7-70.9)	0.5% Carboxy methyl cellulose	NA	Oral	[20]
AgNP	NANOTECH Co, Korea	CMD 56 nm GSD 1.46	0.5% Carboxy methylcellulose	NA	Oral	[22]
AgNP	ABC Nanotech, Korea, OECD WPMN reference material	CMD 10 nm GSD 1.28	0.9% citrate	NA	Oral	[21]
AgNP	ABC Nanotech, Korea, OECD WPMN reference material	CMD 25 nm GSD 2.1	0.9% citrate	NA	oral	[21]
AgNP	Daedeok Science, Korea	CMD 18 nm GSD 1.5	Aerosol	Evaporation and condensation from silver wire	Inhalation	[24]
AgNP	INEXUS INC, Korea	CMD 18.1-19.6 GSD 1.40	Aerosol	Evaporation and condensation from silver wire	Inhalation	[23]
AgNP	ABC Nanotech, Korea, OECD WPMN reference material	CMD 10 nm GSD 1.28	0.9% citrate	MA	intravenous	[25,26]

Table 1: Nanoparticle identification
NM, nanomaterial; AgNP, silver nanoparticle; NA, not applicable

AgNP size (nm)	Route of exposure/sex	Duration	Dose/Conc	Blood Agconc (?/g)	platelet	PT	APTT	Toxicity	Ref
60	Oral/MF	28-d	0, 30, 300, 1000 mg/kg	M: 0.01, 0.18, 0.43, 0.80 F: 0, 0.16, 0.44, 0.70		-	Shortening in the high dose (1000 mg/kg/d in female rats	Liver toxicity from 300 mg/kg	[20]
56	Oral/MF	90-d	0, 30, 125, 500 mg/kg	M: 0.001, 0.111, 0.191, 0.419 F: 0.002, 0.087, 0.122, 0.303		-	-	Liver toxicity from 125 mg/kg	[22]
10	Oral/MF	28-d	0, 100, 500 mg/kg	M: 0, 0.17, 0.27 F: 0, 0.23, 0.33		-	-	-	[21]
25	Oral/ MF	28-d	0, 100, 500 mg/kg	M: 0, 0.11, 0.31 F: 0, 0.16, 0.26	Decreased at 500 mg/kg female rats after 2-month recovery	Increased in the high dose	-	-	[21]
18	Inhalation	90-d/MF	0, 49, 133,, 515 ?/m3	M: 0.00009, 0.00068, 0.0018, 0.0043 F: 0.00005, 0.00085, 0.0021, 0.0069			-	Liver toxicity and lung inflammation from 515 ?/m3;; increased percent of erythrocyte aggregation in the high concentration female	[24]
18.1-19.6	Inhalation	28-d. PEO-28/M	0.31, 82, 116 ?/m3	ND			decreased significantly after 28-day exposure at all concentrations	Lung inflammation from 82 ?/m3	[23]
10	IV injection	28-d/M	0, 10, 100 痢/kg/d	M: 0, 0.0016, 0.0016			-	-	[25,26]

Data quality	OECD WPMN Category	GLP compliance	Based on OECD test guidelines	Peer-review publication
High	1or 2	Yes	Yes	Yes
Medium	1 or 2	No	Yes/no	Yes/no
Low	4	No	No	No