|
Popliteal aneurysm (P) (n=48) |
Control group (V) (n=49) |
||
|
male |
female |
male |
female |
Age |
44 (74.5 years) |
4 (78.25 years) |
19 (51.5 years) |
30 (51.6 Years) |
Nicotin, active |
28 (63.6 %) |
2 (50.0%) |
9 (47.3%) |
15 (50.0%) |
Ex-nicotin |
16 (36.4 %) |
0 |
0 |
0 |
Hypertension |
44 (100%) |
2 (50%) |
3 (15.7%) |
3 (10.0%) |
Diabetes |
11 (25%) |
1 (25%) |
0 |
0 |
Hyperlipoproteinaemia |
23 (52.2%) |
1 (25%) |
0 |
1 (3.3%) |
Hyperuricaemia |
3 (6.8%) |
0 |
0 |
0 |
CHD |
20 (45.4%) |
1 (25%) |
0 |
1 (3.3%) |
Carcinoma |
10 (2.3%) |
2 (50.0%) |
1 (5.2%) |
1 (3.3%) |
Renal insufficiency |
7 (15.9%) |
0 |
0 |
0 |
COPD, emphysema |
6 (13.6%) |
0 |
0 |
0 |
Table 1: Characterization of the study cohort
Continous variables are presented as mean + standard deviation. Categorical variables are presented as an absolute percentage. Abbreviations: CHD: Corona Heart Disease, COPD: Chronic Obstructive Pulmonary Diasease
|
V (control group without aneuryms) |
P with popliteal |
p-value |
Gender |
% within diagnosis |
% within diagnosis |
|
female |
31 (63.3%) |
3 (6.3%) |
|
male |
18 (36.7%) |
45 (93.8%) |
< 0.0001 |
Ex |
5 (10.2%) |
11 (22.9%) |
|
Smoking |
21 (42.9%) |
33 (68.8%) |
< 0.0001 |
No smoking |
23 (46,9%) |
4 (8.3%) |
|
Table 2: Association of male gender, age and smoking for diagnosis of popliteal aneurysm
Ex: ex smoking
Popliteal aneurysm occurs predominantly in male patients and in smokers.
|
V N=49 |
P N=48 |
p- value |
i (n=117, 60.%) |
59 (60.2%) |
58 (60.4%) |
|
d (n=77, 39.7%) |
39 (39.8%) |
38 (39.6%) |
|
|
|
|
1.0 |
Odd ratio (95% CI) |
0.996 |
1.004 |
|
Table 3: distribution i or d allele
Continous variables are presented as mean + standard deviation. Categorical variables are presented as an absolute percentage. Abbreviations: CHD: Corona Heart Disease, COPD: Chronic Obstructive Pulmonary Diasease
|
V N=49 |
P N=48 |
p-value |
ii (n=34, 35.1%) |
18 (36.7%) |
16 (33.3%) |
|
id (n=49, 50.5%) |
23 (46.9%) |
26 (54.2%) |
|
dd (n=14, 14,4%) |
8 (16.3%) |
6 (12.5%) |
|
|
|
|
0.749 |
Table 4: Distribution of NF‐κB genotypes
|
V N=49 |
P N=48 |
p-value |
ii (n=34, 35.1%) |
18 (36.7%) |
16 (33.3%) |
|
di + dd (n=63, 64.9%) |
31 (63.3%) |
32 (66.7%) |
|
del vs. ins (ii/di+dd) |
|
|
0.832 |
ii + dd (n=48, 49.5%) |
26 (53.1%) |
22 (45.8%) |
|
id (n=63, 64.9%) |
23 (49.6%) |
26 (54.2%) |
|
id vs. others |
|
|
0.545 |
ii + id (n=83, 85.6%) |
41 (83.7%) |
87.5%) |
|
dd (n=14, 14.4%) |
8 (16.3%) |
6 (12.5%) |
|
dd versus others |
|
|
0.774 |
Odd ratio (95% CI) |
V N=49 |
P N=48 |
del vs. ins (ii/di+dd) |
1.076 (0.718-1.612) |
0.926 (0.602-1.426) |
id vs. others |
1.154 (0.777-1.714) |
0.864 (0.576-1.295) |
dd versus others |
0.864 (0.523-1.430) |
1.181 (0.622-2.242) |
Table 5: NF‐κB genotype constellations in relation to the popliteal aneurysm
No significant differences in NF‐κB genotype constellations between healthy volunteers and patients with a popliteal aneurysm
|
Regression coefficient B |
Standard |
Sig. |
Odds ratio |
Gender male |
-3.978 |
1.358 |
0.003 |
0.019 |
age |
0.240 |
0.063 |
0.000 |
1,272 |
all smokers (currently |
1.146 |
1.180 |
0.331 |
3.145 |
NFkappaB genotypes |
-0.031 |
0.653 |
0.963 |
0.970 |
NFkappaB genotypes |
-0.432 |
0.909 |
0.635 |
0.649 |
NFkappaB genotypes |
0.340 |
1.229 |
0.782 |
1.405 |
Table 6: Influence of age, male gender, smoking and NFkappa B genotypes for diagnosis of popliteal aneurysm
No influence of NF‐κB genotypes on the popliteal aneurysm
Tables at a glance