Symptoms	Score
	0	1	2	3
Epistaxis	Trivial or < 5	Episode > 5	Consultation	-
Cutaneous	Trivial or < 5	Episode > 5	Consultation	-
Bleeding from m inor wounds	Trivial or <5	Episode > 5	Consultation	-
Oral Bleedin!!:	Trivial or <5	Eoisode > 5	Consultation	-
GI Bleeding	Trivial or <5	-	Consultation	-
Surgery	Trivial or no bleeding	Surgical bleeding episode	Consultation	Surgical hemostasis
Masde/hema rthrosis	Trivial or <5	Episode > 5	Consultation	Compression
Menorrha!!:ia	Trivial or <5	Eoisode > 5	Consultation	Medication

Table 1 : Clinical and biochemical characteristics in OSA patients as well as in control groups x̄±s

Epistaxis
	FVIII normal	FVIII deficient	Fischer’s
No	(60.3) 97	(40.0) 2	0.322
Yes	(39.7) 64	(60.0) 3
	FII normal	FII deficient	Fischer’s
No	(S9.3) 35	(50.0)1	0.656
Yes	(40.7) 24	(50.0)1
	FV normal	FV deficient	Fischer’s
No	(60.4) 29	(58.8) 10	0.565
Yes	(39.6) 19	(41.2) 7
	FVII normal	FVII deficient	Fischer’s
No	(60.3) 38	(50.0) 1	0.644
Yes	(39.7) 25	(50.0) l
	FIX normal	FIX deficient	Fischer's
No	(61.6) 82	(60.0) 3	0.639
Yes	(38.4) 51	(40.0) 2
	FXIII normal	FXIII deficient	Fischer’s
No	(53.7) 22	-
Yes	(46.3) l9	-
	FX normal	FX deficient	Fischer’s
No	(60.0) 33	0	0.41 l
Yes	(40.0) 22	(100) 1
	vWF Ag normal	vwf Ag deficient	Fischer’s
No	(60.0) 99	-
Yes	(40.0) 66	-
	vWF Activity normal	vWF Activity deficient	Fischer’s
No	(61.4) 97	(50.0) 7	0.288
Yes	(38.6) 61	(50.0) 7
Cutaneous Symptoms
	FVIII normal	FVIII deficient	Fischer’s
No	(64.0) 103	(40.0) 2	0.26
Yes	(36.0)58	(60.0) 3
	FII normal	FII deficient	Fischer’s
No	(61.0)36	( 100)2	0.384
Yes	(39.0)23	0
	FV normal	FV deficient	Fischer’s
No	(64.6)31	(64.7) 11	0.617
Yes	(35.4) 17	(35.3) 6
	FVII normal	FVII deficient	Fischer’s
No	(65.0}41	-	0.586
Yes	(35.0}22	-
	FIX normal	FIX deficient	Fischer’s
No	(60.2)80	(100) 5	0.085
Yes	(39.8)53	0
	FXII normal	FXII deficient	Fischer’s
No	(73.3)33	-
Yes	(26.7) 12	-
	FXIII normal	FXIII deficient	Fischer’s
No	(51.2)21	-
Yes	(48.8)20	-
	FX normal	FX deficient	Fischer’s
No	(60.0)33	0	0.411
Yes	(40.0)22	(100) 1
	vWF Ag normal	vwfAg deficient	Fischer’s
No	(64.2) 106	-
Yes	(36.)59	-
	vWF Activity normal	vWF Activity deficient	Fischer’s
No	(66.5) 105	(64.3) 9	0.541
Yes	(33.5)53	(35.7) 5
Bleeding Minor Wounds
	FVIII norma1	FVJ II deficient	Fischer’s
No	(81.4) 131	(80.0)4	0.65
Yes	(18.6)30	(20.0) 1
	FII normal	Fil deficient	Fischer's
No	(74.6) 44	(100.0)2	0.566
Yes	(25.4) 15	0
	FV normal	FV deficient	Fischer’s
No	(77.1) 37	(76.5) 13	0.6
Yes	(22.9) 11	(23.5) 4
	FVII normal	FVII deficient	Fischer’s
No	(77.8) 49	(50.0) 1	0.411
Yes	(22.2) 14	(50.0) 1
	FIX normal	FIX deficient	Fischer’s
No	(80.5) 107	(60.0) 3	0.267
Yes	( 19.5) 26	(40.0) 2
	FXIII normal	FXIII deficient	Fischer’s
No	(75.6)31	-
Yes	(24.4) 10	-
	FX normal	FX deficient	Fischer’s
No	(74.5) 41	(100) 1	0.75
Yes	(25.5) 14	0
	vWF Ag normal	vwf Ag deficient	Fischer’s
No	(82.4) 136	-
Yes	(17.6) 29	-
	vWF Activity normal	vWF Activity deficient	Fischer’s
No	(81.6) 129	(92.9) 13	0.258
Yes	(18.4) 29	(7.1) 1
Ora l Bleeding
	FVIII normal	FVIII present	Fischer’s
No	(46.0) 74	(60.0) 3	0.432
Yes	(54.0) 87	(40.0) 2
	FII normal	FII deficient	Fischer’s
No	(54.2) 32	0	0.222
Yes	(45.8) 27	(100.0) 2
	FV normal	FV deficient	Fischer’s
No	(56.2) 27	(47.1 ) 8	0.579
Yes	(43.8) 21	(52.9) 9	0.355
	FVII normal	FVII deficient	Fisd1er's
No	(54.0) 34	(50.0) 1	0.714
Yes	(46.0) 29	(50.0) 1
	FIX normal	FIX deficient	Fischer's
No	(44.4) 59	(60.0) 3	0.404
Yes	(55.6) 74	(40.0) 2
	FXIII normal	FXIII deficient	Fischer’s
No	(48.8) 20	-
Yes	(51.2) 21	-
	FX normal	FX deficient	Fischer’s
No	(52.7) 29	0	0.482
Yes	(47.3) 26	(100) 1
	vWF Ag normal	vwf Ag deficient	Fischer’s
No	(45.5) 75	-
Yes	(54.5) 90	-
	vWF Activity normal	vWF Activity deficient	Fischer’s
No	(45.6) 72	(50.0) 7	0.482
Yes	(54.4) 86	(50.0) 7
GI Bleeding
	FVIII normal	FVIII deficient	Fischer’s
No	(92.5) 149	(80.0) 4	0.338
Yes	(7.5) 12	(20.0) 1
	FII normal	FII deficient	Fisdier's
No	(81.4) 48	( 100) 2	0.669
Yes	(18.6) 11	0
	FV normal	FV deficient	Fischer's
No	(89.6)43	(64.7) 11	0.028
Yes	(10.4) 5	(35.3) 6
	FVII normal	FVII deficient	Fisdier's
No	(82.5) 52	(100) 2	0.688
Yes	( 17.5) 11	0
	FIX normal	FIX deficient	Fischer's
No	(91.7) 122	(100.0) 5	0.656
Yes	(8.3) 11	0
	FXIII normal	FXIII deficient	Fischer’s
No	(85.4)35	-
Yes	(14.6) 6	-
	FX normal	FX deficient	Fischer's
No	(80.0) 44	(100) 1	0.804
Yes	(20.0) 11	(0) 0
	vWF Ag normal	vwfAgdeficient	Fischer's
No	(92.7) 153	-
Yes	(7.3) 12	-
	vWF Activity normal	vWF Activity deficient	Fischer’s
No	(93.0) 147	(92.86) 13
Yes	(7.0) 11	(7.1) 1
Surgery
	FVIII normal	FVIII deficient	Fischer’s
No	(83.8) 135	(100) 5	0.422
Yes	(16.2) 26	0
	FII normal	FII deficient	Fischer's
No	(79.7) 47	(50) 1	0.384
Yes	(20.3) l 2	(50) 1
	FV normal	FY deficient	Fischer’s
No	(87.5) 42	(58.8) 10	0.017
Yes	( 12.5)6	(41.2) 7
	FVII normal	FVII deficient	Fischer’s
No	(80.9)51	(50.0) 1	0.363
Yes	(19.1) 12	(50.0) 1
	FIX normal	FIX deficient	Fischer’s
No	(83.5) 111	(60.0) 3	0.208
Yes	(16.5) 22	(40.0) 2
	FXIII normal	FXIII deficient	Fischer’s
No	(82.9)34	-
Yes	( 17.1) 7	-
	FX normal	FX deficient	Fischer’s
No	(80.0)44	(100) 1	0.804
Yes	(20.0) 11	(0) 0
	vWF Ag normal	vwf Ae: deficient	Fischer’s
No	(83.6) 138	-
Yes	(16.4) 27	-
	vWF Activity normal	vWF Activity deficient	Fischer’s
No	(84.2) 133	(85.7) 12	0.619
Yes	(15.8) 25	(14.3) 2
Muscle/ hemarthrosis
	FVIII normal	FVIII deficient	Fischer’s
No	(96.3)155	(100) 5	0.83
Yes	(3.7) 6	0
	FII normal	FII deficient	Fischer’s
No	(96.6) 57	(3.4) 2	0.935
Yes	(3.4) 2	0
	FV normal	FV deficient	Fischer’s
No	(97.9) 47	(94.1) 16	0.458
Yes	(2.1) 1	(5.9) 1
	FVII normal	FVII deficient	Fischer’s
No	(96.8) 61	(100) 2
Yes	(3.2) 2	0
	FIX normal	FIX deficient	Fischer’s
No	(95.5) l 27	(100.0) 5	0.798
Yes	(4.5) 6	0
	FXIII normal	FXIII deficient	Fischer’s
No	(95. l) 39	-
Yes	(4.9) 2	-
	FX normal	FX deficient	Fischer’s
No	(96.4) 53	(100) 1	0.964
Yes	(3.6)2	(0) 0
	vWFAg normal	vwf Ag deficient	Fischer’s
No	(96.4)159	.
Yes	(3.6) 6	.
	Vwf Activity normal	Vwf Activity deficient	Fischer’s
No	(96.2) 152	(100.0) 14	0.596
Yes	(3.8) 6	0
Menorrhagia
	FVIII normal	FVIII deficient	Fischer’s
No	(75.3) 76	(75.0) 3	0.686
Yes	(24.7125	(25.0)1
	FII normal	FII deficient	Fischer’s
No	(63.2)24	0	0.385
Yes	(36.8) 14	(100) 1
	FV normal	FV deficient	Fischer's
No	(60.6) 20	(71.4) 5	0.467
Yes	(39.4) 13	(28.6)2
	FVII normal	FVII deficient	Fischer's
No	(64.1)25	0	0.375
Yes	(35.9) 14	(100) 1
	FIX normal	FIX deficient	Fischer's
No	(73.6)67	(100)2	0.548
Yes	(26.4) 24	0
	FXIII normal	FXIII deficient	Fischer's
No	(71.9) 23	.
Yes	(28.1)9	.
	FX normal	FX deficient	Fischer's
No	(61.1) 22	(100) 1	0.622
Yes	(38.9)14	(0) 0
	vWFAg normal	Vwf Ag deficient	Fischer's
No	(74.5) 76	.
Yes	(25.5) 26	.
	Vwf Activitvy nonnal	Vwf Activity deficient	Fischer's
No	(74.7)74	(80.0) 4	0.633
Yes	(25.3)25	(20.0) 1

Table 2 : Relationship between bleeding questions and clotting factors

Epistaxis
	PT normal	PT prolon ged	Fischer's
No	(56.6) 232	(65.2) 150	0.02
Yes	(43.4) 178	(34.8) 80
	APT normal	APT prolonged	Fischer's
No	(58.0) 134	(60.8) 247	0.269
Yes	(42.0) 97	(39.2) 159
Cutaneous symptoms
	PT normal	PT prolonged	Fischer's
No	(71.5) 293	(74.4) 171	0.245
Yes	(28.5) 117	(25.6) 59
	APT normal	APT prolonged	Fischer's
No	(62.3) 144	(78.3) 318	0.0001>
Yes	(37.7) 87	(21.7) 88
Bleeding minor wounds
	PT normal	PT prolonged	Fischer's
No	(80.5) 330	(78.3) 180	0.283
Yes	(l9.5}80	(21.7) 50
	APT normal	APT prolonged	Fischer's
No	(75.8} 175	(82.0) 333	0.038
Yes	(24.2) 15	(18.0) 73
Oral Bleeding
	PT normal	PT prolonged	Fischer's
No	(40.5) 166	(50.0) 115	0.012
Yes	(59.5) 244	(50.0) 115
	APT normal	APT prolonged	Fischer's
No	(45.0) 104	(42.8) 174	0.327
Yes	(55.0} 127	(57.2) 232
GI bleeding
	PT normal	PT prolonged	Fischer's
No	(91.9}377	(89.1) 205	0.147
Yes	(8.1) 33	( l0.9) 25
	APT normal	APT prolonged	Fischer's
No	(89.2) 206	(91.9) 373

Factors	Score range	Likeli hood
FVIII (n= l 5)	0-9	Score 0 likelihood 0.42
FIX (5)	0-5	Score 1 likelihood 0.60
FXI (0)	N/A	N/A
FXIII (0)	N/A	N/A
vWFAg (11)	I	N/A
vWF-activitvy ( 14)	0-5	Score 1 likelihood 0.57
FII (2)	1	NIA
FV ( 17)	5-Jan	Score 1 likelihood 0.5
(FVII (2)	5	N/A
FX (1)	N/A	N/A

Tables at a glance

Figures at a glance