Author	Bianco		Rocha		Davierwala		Nambiar		Raja
Acronym					SYNTAX Extended
Date	2023		2022		2021		2019		2018
Follow-up	5 years		5 years		11.9 years		3years		5 years
	PCI(n=838)	MAG(n=838)	PCI(n=1027)	MAG(n=1027)	PCI(n=901)	MAG(n=310)	PCI(n=903)	MAG(n=940)	PCI(n=1126)	MAG(n=1030)
Age (years)			59.8(7.4)	59.5(7.4)	65.3(9.6)	62.4(9.9)	65.2(9.7)	61.7(8.9)	55	62
Male sex (%)	77.8	83.1	84.8	85.4	76.5	85.2	76.4	64.9	77.6	87.7
CAD risk factors
Diabetes (%)	44.2	41.6	42.9	42.6	25.7	23.2	25.6	89.2	21.3	18.1
Hypertension (%)	86.9	87.1	70.6	69.3	69.4	63.2	68.9	61.2	53.2	78.1
Dyslipidaemia (%)	86.8	89.3	40.5	40.2	78.3	78.6	78.7	46.8
Current smokers (%)	25.4	24.5	19.5	19.6	18.3	24.4	18.5	16.7	19.1	12
Preoperative risk factors
Previous MI (%)			12.7	12.6	32	29.2	31.9	56	35.4	43.5
Previous cerebrovascular disease	16	16.9	2.4	2.3	13.4	16.8	8.2	2.4	1.8	3.5
Peripheral vascular disease (%)	17.5	19.1			9	9.7			1.5	7.8
COPD (%)	15.8	15.5	12.5	12.9	8.1	6.8		13
Congestive heart failure (%)	11.6	8.7	6.4	5.6	3.9	2.6	4
Clinical presentation
Stable angina (%)	45.1	51.3			57	51.6	56.9		45.7	65.9
Disease type
3-vessel disease (%)	73.3	80	41.9	40.5	59	64.5
LMCAD (%)			2.6	2.4	41	35.5
Author	Thuijs		Benedetto		Locker		Habib		Moshkovitz
Acronym	EXCEL
Date	2018		2016		2016		2015		2012
Follow-up	3years		3.1years		7.9 years		9years		5years
	PCI(n=948)	MAG(n=217)	PCI(n=483)	MAG(n=483)	PCI(n=872)	MAG(n=872)	PCI(n=546)	MAG(n=546)	PCI(n=271)	MAG(n=226)
Age (years)	66.0(9.6)	64.5(9.3)	66(12)	65(9)	66.8(11.6)	62.4(9.9)	60.1(12.8)	60.7(8.1)
Male sex (%)	76.2	85.7	75.6	79.9	26.4	85.2	77.3	75.6	73.4	85.8
CAD risk factors
Diabetes (%)	30.2	33	19	16.8	32.6	34.9	38.5	37	100	100
Hypertension (%)	74.5	67.3	68.7	69.6	80.7	83	59.5	9.5	68.6	78.3
Dyslipidaemia (%)	71.5	67.7							75.6	70.4
Current smokers (%)	24.1	62	20.7	18.2
Preoperative risk factors
Previous MI (%)	18.1	11.5	33.5	32.5	27.3	27.1	34.6	33.7	21.8	33.6
Previous cerebrovascular disease (%)	5.5	4.6	2.9	2.3	8.4	8.2
Peripheral vascular disease (%)	10.3		11.2	9.1	12.5	12			5.2	11.9
COPD (%)	6.9	6			10.8	10.5	6	8.4	3.7	3.5
Congestive heart failure (%)	7.1	5.1	26.5	25.7	9.7	9.9	5.5	5.5	9.6	12.4
Clinical presentation
Stable angina (%)	53.1
Disease type
3-vessel disease (%)			24.6	24.6	57.8	61.2	83.3	84.1	57.6	21.2
LMCAD (%)	100	100	15.1	17.2	5.6	6.5	29.3	8.2	4.1	27
Author		Herz			Herz			Locker
Acronym
Date		2006			2005			2004
Follow-up		1year			3years			6.5years
		PCI(n=87)		MAG(n=87)	PCI(n=113)		MAG(n=113)	PCI(n=363)		MAG(n=439)
Age (years)					60.0(10)		60.1(10)
Male sex (%)		93.1		93.1	95.6		95.6	73		71
CAD risk factors
Diabetes (%)		44.8			36.3		32.7	100		100
Hypertension (%)		64.4			61.1		59.3	49		57
Dyslipidaemia (%)		70.1			72.6		70.8
Current smokers (%)
Preoperative risk factors
Previous MI (%)		32.2			38.9		35.4	37		39
Previous cerebrovascular disease (%)
Peripheral vascular disease (%)		5.7			8.3		6.7	10		9.8
COPD (%)		4.6			4.4		2.7	3		8.4
Congestive heart failure (%)		6.9			6.2		6.2
Clinical presentation
Stable angina (%)
Disease type
3-vessel disease (%)		51.7		51.7	54		54	27		87
LMCAD (%)		3.5		29.1	3.5		26.5	3.3		28

- : CAD=coronary artery disease; COPD=chronic obstructive pulmonary diseases; LMCD=left main coronary artery disease: MAG=multiple ar- terial bypass graft surgery; MI=myocardial infarction; PCI=percutaneous coronary intervention.
Table S1 : The characteristics of the study included

	CABG	PCI	RR	95%CI	p	2 I(%)
MA-CABG vs F-DES
MACCE	339	384	0.40	0.30-0.54	<0.0001	0
All cause death	2835	2489	0.27	0.11-0.63	0.02	90
MI	1579	1466	0.20	0.04-1.03	0.05	75
Repeat revascularization	1805	1737	0.17	0.05-0.60	0.006	95
MA-CABG vs S-DES
MACCE	1244	1975	0.41	0.26-0.63	<0.0001	66
All cause death	2274	3101	0.39	0.23-0.68	0.0009	69
MI	1244	1975	0.43	0.11-1.68	0.22	92
Repeat revascularization	1244	1975	0.16	0.12-0.22	<0.0001	28
BITA-CABG vs PCI
MACCE	556	1332	0.45	0.35-0.57	<0.0001	0
All cause death	2022	2685	0.26	0.09-0.72	0.009	89
Stroke	1270	1964	0.19	0.08-0.47	0.0004	16
MI	1796	2414	0.30	0.06-1.49	0.14	88
Repeat revascularization	2022	2685	0.15	0.05-0.47	0.001	94

Tables at a glance

Figures at a glance