1 Nowak-Solinska E, Rabie AB, Wong RW, Lei SW (2012)The effect of naringin on early growth and development of the spheno-occipital synchondrosis as measured by the expression of PTHrP and SOX-9 in vitro model. Eur J Orthod .
2 Lekic PC, Nayak BN, Al-Sanea R, Tenenbaum H, Ganss B, et al. (2005) Cell transplantation in wounded mixed connective tissues. Anat Rec A Discov Mol Cell Evol Biol 287: 1256-1263.
3 Kim HJ, Choi YS, Jeong MJ, Kim BO, Lim SH, et al. (2007) Expression of UNCL during development of periodontal tissue and response of periodontal ligament fibroblasts to mechanical stress In vivo and vitro. Cell Tissue Res 327: 25-31.
4 Henneman S, Von den Hoff JW, Maltha JC (2008) Mechanobiology of tooth movement. Eur J Orthod 30: 299-306.
5 Yoshizawa T, Takizawa F, Iizawa F, Ishibashi O, Kawashima H, et al. (2004) Homeobox protein MSX2 acts as a molecular difference mechanism for preventing ossification in ligament fibroblasts. Mol. Cell Biol 24: 3460-3472.
6 McCulloch CA (1985) Progenitor cell populations in the periodontal ligament of mice. Anat Rec 211: 258-262.
7 Lekic PC, Pender N, McCulloch CA (1997) Is fibroblast heterogeneity relevant to the health, disease, and treatment of periodontal tissues? Critic Rev Oral Biol Med 8: 253-268.
8 Nayak BN, Wiltshire W, Ganss B, Tenenbaum H, McCulloch CA, et al. (2008) Healing of periodontal tissues following transplantation of cells in a rat orthodontic tooth movement model. Angle Orthod 78: 826-8231.
9 Nakagawa M, Kukita T, Nakashima A, Kurisu K (1994) Expression of the Type I Collagen Gene in rat periodontal ligament during tooth movement as revealed by in situ-hybridization. Arch Oral Biol 39: 289-294.
10 Bumann A, Carvalho RS, Schwarzer CL, Yen EH (1997) Collagen synthesis from human PDL cells following orthodontic tooth movement. Eur J Orthod 19: 29-37.
11 Tashiro K, Sawada T, Inoue S, Yanagisawa T (2002) Development of oxytalan fibers in the rat molar periodontal ligament. J Periodontal Res 37: 345-352.
12 Häkkinen L, Strassburger S, Kähäri VM, Scott PG, Eichstetter I, et al. (2000) A role of decorin in the structural organisation of periodontal ligament. Lab Invest 80: 1869-1880.
13 Waddington TJ, Embery G (2001) Proteoglycans and orthodontic tooth movement. J Orthod 28: 281-290.
14 Krisnan V, Davidovitch Z (2006) Cellular, molecular and tissue-level reactions to orthodontic force. Am J Orthod Dentofacial Orthop 129: 469e1- 469e32.
15 Krishnan V, Davidovitch Z (2009) On a path to unfolding the biological mechanisms of orthodontic tooth movement. J Dent.Res 88: 597-608.
16 Rubin J, Rubin C, Jacobs CR (2006) Molecular pathways mediating mechanical signaling in bone. Gene 367: 1-16.
17 Goulet GC, Cooper DM, Coombe D, Zernicke RF (2008) Influence of cortical canal archit-tecture on lacunocanalicular pore pressure and fluid flow. Comput Methods Biomed Eng 11: 379-387.
18 Norevall Li, Forsgren S, Matsson L (1995) Expression of neuropeptide (CCRP, substance P) during and after orthodontic tooth movement in the rat. Eur J Orthod 17: 311-325.
19 Sacerdote P, Levrini L (2012) Peripheral mechanism of dental pain: The role of Substance P. Mediators Inflamm 2012: 951920.
20 Hall M, Masella R, Meister M (2001) PDL–neurone associated neurotransmitters in orthodontic tooth movement: identification and proposed mechanism of action. Todays FDA 13: 24-25.
21 Yamaguchi N, Chiba M, Mitani H (2002) The induction of c-fos mRNA expression by mechanical stress in human periodontal ligament cells. Arch Oral Biol 47: 465-471.
22 Yang YQ, Tan YY, Wong R, Wenden A, Zhang LK, et al. (2012) The role of vascular endothelial growth in ossification. Int J Oral Sci 4: 64-68.
23 Jackson WM, Jaasma MJ, Tang RY, Keaveny TM (2008) Mechanical loading by fluid shear is sufficient to alter the cytoskeletal composition of osteoblastic cells. Am J Physiol Cell Physiol 295: C1007-C1015.
24 Nishida E, Gotoh Y (1993) The MAP kinase cascade is essential for diverse signal transduction pathways. Trends Biochem Sci 18: 128-131.
25 Wang HB, Dembo M, Hanks SK, Wang Y (2001) Focal adhesion kinase is involved in mechanosensing during fibroblast migration. Proc Natl Academ Sci (USA) 98: 22295-11300.
26 Wang Y, McNamara Lm, Schaffer MB, Weibaum (2007) A model for the role of integrins in flow induced mechanotransduction in osteocytes. Proc Natl Acad Sci (USA) 104: 15941-15946.
27 Taylor AF, Saunders MM, Shingle DL, Cimbala JM, Zhou Z, et al. (2007) Mechanically stimulated osteocytes regulate osteoblastic activity via gap junctions. Am Physiol Cell Physiol 292: C545-C552.
28 Li J, Zhao Z, Wang J, Chen G, Yang J, et al. (2008) The role of extracellular matrix, integrinsan;d cytoskeleton in mechanotransduction of centrifugal loading. Mol Cell Biochem 309: 41-48.
29 Chang HH, Wu CB, Chen YJ, Weng CY, Wong WP, et al. (2008) MMP-3 response to compressive forces in vitro. J Dent Res 87: 692-696.
30 Yang CM, Chien CS, Yao CC, Hsiao LD, Huang YC, et al. (2004) Mechanical strain induces collagenase-3(MMP-13) in MC3T3-E1 osteoblastic cells. J Biol Chem 279: 22158-22165.
31 Brooks PJ, heckler AF, Wei K, Gong SG (2011) M-CSF accelerates orthodontic tooth movement by targeting preosteoblasts in mice. Angle Orthodontist. 82: 277-283.
32Huang W, Chung UI, Kronenberg HM, de Crombrugghe B, et al. (2008) The chondrogenic transcription factor SOX 9 is a target of signaling by the parathyroid hormone-related peptide in the growth plate of endochondral bones. Proc. Natl. Aca. Sci (USA) 98: 160-165.
33 Akiyama H, Chaboissier MC, Martin JF, Schedl A, de Crombrugghe B, et al. (2002) The transcription factor SOX 9 has essential roles in successive steps of the chondrocytes differentiation pathway & is required for expression of SOX 5 and SOX 6. Genes Dev 16: 2813-2828.
34 Ouyang H, McCauley LK, Berry JE, Saygin NE, Tokiyasu Y, et al. (2000) Parathyroid hormone-relatedprotein regulates extracellular matrix gene expression in cementoblasts and inhibitscementoblast-mediated mineralization in vitro J Bone and Mineral. Res 15: 2140-2153.
35 Hughes FJ (1995) Cytokine and cell signaling in the periodontium. Oral Disease. 1: 259-265.
36 Alhashimi N, Frithiof I, Bridvik P, Bakhiet M (1999) Chemokines are upregulated during orthodontic tooth movement. J Interferon Cytokine Res 19: 1047-1052.
37 Yamamoto T, Kita M, Oseko F, Nakamura T, Imanishi J, et al. (2006) cytokine production in human periodontal ligament cells with porphyromonas gingivitis. J. Periodontal Res. 41: 554-559.
38 Worapamorn W, Haase HR, Li H, Bartold PM (2001) Growth factors and cytokines modulate gene expression of cell surface proteoglycans in human periodontalligament cells. J. Cell Physiol 186: 448-456.
39 Okuda K, Kawase T, Momose M, Murata M, Saito Y, et al. (2003) Plateletrich plasma contains high levels of platelet derived growth factor and transforming growth factor beta and modulates the proliferation of periodontally related cells in vitro. J Period 74: 1513-1523.
40 Kurat H, Guillot PV, Chan J, Fisk NM (2007) Osterix induces osteogenic gene expression but not differentiation in primary mesenchymal stem cells. Tissue Engineer 13: 1513-1523.
41 Yamaguchi M (2009) RANK/RANKL/OPG during orthodontic tooth movement. Orthod Craniofac Res 12: 113-119.
42 Matsubara T, Kida K, Yamaguchi A, Hata K, Ichida F, et al. (2008) BMP 2 regulates osterix through msx2 and Run-x-2 during osteoblast differentiation. J Biol Chem 283: 29119-29125.
43 Franceschi RT, Xiao G, Jiang D, Gopalakrishnan R, Yang S, et al. (2003) Multiple signaling pathways converge on the cbfa1/Run x2 transcription factor to regulate osteoblast differentiation. Connective Tissue Res 44: 109-116.
44 Zhao M, Xiao G, Berry JE, Franceschi RT, Reddi A, et al. (2002) Bone morphogenetic protein 2 induces dental follicle cells to differentiate toward a cementoblast/osteoblast phenotype. J Bone and Miner Res 17: 1441-1451.
45 Tulchinsky E (2000) Fos family members: regulation, structure & role in oncogenic transformation. Histol Histopath 15: 921-928.
46 Petersen DN, Tkalcevic GT, MansolfAL, Rivera-Gonzalez R, Brown TA (2000) Identification of osteoblast/osteocyte factor 45, a bone-specific cDNA encoding RGD –containing protein that is highly expressed in osteoblasts and osteocytes.J Biol Chem 275: 36172-36180.
47 Di Domenico M, D'apuzzo F, Feola A, Cito L, Monsurrò A, Pierantoni GM, et al. (2012) Cytokines and VEGF induction in orthodontic movement in animal model. J Biomed. Biotechnology. 2012: 201689.
48 Reddi AH, Reddi A (2009) Bone morphogenetic protein (BMP): from morphogen to metbologens. Cytokine growth Factor Rev 20: 341-342.
49 Han MX, Li Lu, Wang ZD (2013) Expression of osteopontin in periodontal during orthodontic tooth movement. Oral BioMedicine. 4: 79-82.
50 Takahashi I, Nishimura M, Onodera K, Bae JW, Mitani H (2003) Expression of MMP 8 and MMP 13 genes in the periodontal ligament during orthodontic tooth movement in rats. J Dent Res 82: 646-651.
51 Binderman I, Bahar H, Jacob-Hirsch J, Zeligson S, Amariglio N, et al. (2007) P2X4 is upregulated in gingival fibroblasts after periodontal surgery. J Dent Res 86: 181.
52 Patil A, Jayade VP (2006) Advances in Biology of Orthodontic Tooth Movement. A Review. J Ind Orthod Soc 39: 155-164.
53 Denhardt DT, Guo X (1993) Osteopontin: a protein with diverse functions. FASEB 17: 1475-1482.
54 Reinholt FP, Hultenby K, Oldberg A, Heinegård D (1990) Osteopontin- a possible anchor of osteoclasts to bone. Proc Natl Acad Sci (USA) 87: 4473- 4475.
55 Terai K, Takano-Yamamoto T, Ohba Y, Hiura K, Sugimoto M, et al. (1999) Role of osteopontin in bone remodeling caused by mechanical stress. J Bone Miner Res 14: 839-849.
56 Kim JY, Kim BI, Jue SS, Park JH, Shin JW (2012) Localization of osteopontin and osterix in periodontal tissue during orthodontic tooth movement in rats. Angle Orthod. 82: 107-114.
57 Nifforoushan D, Manolson M (2009) Expression of nitric oxide synthases in orthodontic tooth movement. Angle Orthod 79: 502-508.
58 Hayashi K, Igarashi K, Miyoshi K, Shinoda H, Mitani H (2002) Involvement of nitric oxide in orthodontic tooth movement in rats. Am J Orthod Dentofacial Orthop 122: 306-309.
59 Alhashimi N, Frithiof AN, Brudvik P, Bakhiet M (2001) Orthodontic tooth movement and de novo synthesis of proinflammatory cytokines. Am J Orthod Dentofac Orthop119: 307-312.
60 Rooker SM, Liu B, Helms JA (2010) Role of Wnt signaling in the biology of periodon-tium. Dev. Dyn. 239: 140-147.
61 Kook YA, Lee SK, Son DH, Kim Y, Kang KH, et al. (2009) Effects of Substance P on osteoblastic differentiation and hemeoxygenase -1 in human periodontal ligament cells. Cell Biol Int 33: 424-428.