Figure 1 Arestin used in the study

Figure 2 Application of the minocycline at the test site.

Control sites			Minocycline sites			Clinical parameters
At 6 months	At 3 months	Baseline	At 6 months	At 3 months	Baseline	Clinical parameters
0.85 ą 0.15	1.15 ą 0.25	2.58 ą 0.36	0.71 ą 0.25	1.06 ą 0.29	2.46 ą 0.54	Mean ą SD	Plaque index
32.50	33.17	50.35	33.45	35.77	52.12	Percentage (%)	Bleeding upon probing index

Table1 Plaque index and bleeding upon probing values of minocycline sites versus control sites at time intervals.

Values are expressed as mean ą SD and percentage

Control sites			Minocycline sites			Clinical parameters
At 6 months	At 3 months	Baseline	At 6 months	At 3 months	Baseline	Clinical parameters
4-6	4-7	5-8	4-6	4-6	5-8	Range	Probing pocket depth
5.58ą0.41	5.9ą0.6	6.53ą0.34	4.4ą0.4 *	4.8ą0.7 *	6.28ą0.5	Mean ąSD	Probing pocket depth
4-7	5-8	5-8	4-7	4-8	5-9	Range	Clinical Attachment level
6.45ą0.7	6.4ą0.3	6.9ą04	5.7ą0.15 *	5.75ą0.35 *	6.8 ą0.2	Mean ąSD	Clinical Attachment level

Table2 The probing pocket depth and clinical attachment level of the minocycline sites versus control sites at time intervals

Values are expressed as range and mean ą SD (* indicates statistical significance at P < 0.05).