TNF-α inhibitors
(Brand Name)

Etanercept
(Enbrel)

Infliximab
(Remicade)

Adalimumab
(Humira)

Golimumab
(Simponi)

Certolizumab pegol (Cimzia)

 Structure

Humanized structure

Combined mice and human structure

Humanized structure

Humanized structure

Humanized structure

Binding Specificity

TNF-α and LT-α

TNF-α

TNF-α

TNF-α

TNF-α

Effect on TNF-α expressing cells

No lysis

Lysis

Lysis

No lysis

No lysis

Used to Treat diseases

Rheumatoid, Juvenile Idiopathic, and Psoriatic Arthritis

Crohn’s Disease, Ulcerative colitis, Rheumatoid and Psoriatic Arthritis, Ankylosing Spondylitis, Moderate to Severe plaque Psoriasis, and Behçet's Disease

Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriatic arthritis

Rheumatoid and Psoriatic Arthritis,  Ankylosing Spondylitis, Ulcerative Colitis

Crohn's disease, Rheumatoid arthritis, Ankylosing Spondylitis, Moderate to Severe plaque Psoriasis