Figure 1 The Helsinki chronic pain index (HCPI) at T0 (tot_T0) and T2 (tot_T2) in 9 cases with baseline HCPI < 20. On the top of each bar the HCPI is reported.

Figure 2 The Helsinki chronic pain index (HCPI) at T0 (tot_T0) and T2 (tot_T2) in the three cases with baseline HCPI >20. On the top of each bar the HCPI is reported.

Ingredients

Quantity in 2.0 gr of tablet (mg)

Hyaluronic acid

18

Appetite stimulants (D'Tech 8P)

134

Collagen type II-not hydrolised

4

Chondroitin sulfate

300

FLEXIDE® (Camellia sinensis (L.) O. Kuntze, Boswellia serrata Roxb. ex Colebr., Copper complexes of chlorophylls E141)

70

Glucosamine hydrochloride

500

Technological additives (antioxidants, emulsifiers, stabilizing agents)

974

Table 1. Ingredients included in the tested supplement. Quantity of each ingredient contained in 2.0 grams of tablet is reported.

Question asked

0 Points

1 Point

2 Points

3 Points

4 Points

Q1

Rate your dog’s mood

Very alert

Alert

Neither alert nor indifferent

Indifferent

Very indifferent

Q2

Rate your dog’s willingness to participate in play

Very willing

Willing

Reluctantly

Very reluctantly

Does not play at all

Q3

Rate your dog’s vocalization (audible complaining)

Never

Hardly ever

Sometimes

Often

Very often

Q4

Rate your dog’s willingness to walk

Very willing

Willing

Reluctantly

Very reluctantly

Does not walk at all

Q5

Rate your dog’s willingness to trot

Very willing

Willing

Reluctantly

Very reluctantly

Does not trot at all

Q6

Rate your dog’s willingness to gallop

Very willing

Willing

Reluctantly

Very reluctantly

Does not gallop at all

Q7

Rate your dog’s willingness to jump (e.g., into car, onto sofa)

Very willing

Willing

Reluctantly

Very reluctantly

Does not jump at all

Q8

Rate your dog’s ease in lying down

With great ease

Easily

Neither easily nor difficultly

With difficulty

With great difficulty

Q9

Rate your dog’s ease in rising from a lying position

With great ease

Easily

Neither easily nor difficultly

With difficulty

With great difficulty

Q10

Rate your dog’s ease of movement after long rest

With great ease

Easily

Neither easily nor difficultly

With difficulty

Very often/always difficulty

Q11

Rate your dog’s ease of movement after major activity or heavy exercise

With great ease

Easily

Neither easily nor difficultly

With difficulty

Very often/always difficulty

Table 2.Helsinki Chronic Pain Index (HCPI) for veterinary use, as translated from Finnish to English based on an article written by Canapp and colleagues [7].

Cases

Degree of lameness

Type of lameness

Overall classification

T0

T1

T2

T0

T1

T2

Case 1

2

1

1

continuous lameness

cold lameness

Intermittent lameness

Improved

Case 2

3

3

2

continuous lameness

continuous lameness

cold lameness

Improved

Case 3

2

2

2

continuous lameness

continuous cold lameness

intermittent cold lameness

Improved

Case 4

2

1

2

continuous lameness

cold lameness

cold lameness

Improved

Case 5

3

1

1

continuous cold lameness

no lameness

no lameness

Success

Case 6

3

2

2

continuous lameness

continuous cold lameness

continuous cold lameness

Improved

Case 7

3

2

1

continuous cold lameness

continuous cold lameness

intermittent lameness

Improved

Case 8

3

2

2

continuous lameness

continuous lameness

cold lameness

Improved

Case 9

4

3

NA

continuous cold lameness

continuous lameness

intermittent cold lameness

Improved

Case 10

2

2

1

Intermittent cold lameness

Intermittent cold lameness

Intermittent cold lameness

Improved

Case 11

4

4

4

continuous cold lameness

continuous lameness

continuous lameness

Failure

Case 12

3

2

2

continuous lameness

continuous lameness

continuous lameness

Improved

Case 13

4

2

2

continuous lameness

NA

cold lameness

Improved

Table 3. Patients’ lameness progression. Degree of lameness at T0, T1 and T2. Type of lameness at T0, T1 and T2. Overall classification of the animal’s condition after 60 days from the beginning of the treatment.