Nutritional characteristics	Amount per portion (5.5 grams)
Calories (kcal)	18
Lipids (g)	0
Carbohydrates (g)	2.1
Fiber (g)	1.0
Protein (g)	1.7
L-Leucine (mg)	1250
L-Isoleucine (mg)	625
L-Valine (mg)	625
HMB (mg) *	750
Vitamin D (mcg)	20
Zinc (mg)	5.0

* HMB: beta-hydroxy-beta-methylbutyrate

Table 1:Characteristics of oral nutritional supplement Hydroxiram D (ErreKappa-Euroterapici, Milano)

Characteristics	Total Sample (n=20)	Men (n=7)	Women (n=13)	p
Age (years)	63.5 ± 14.6	73.7 ± 6.5	57.3 ± 14.9	0.01
Acute COVID-19 characteristics
Pneumonia diagnosed	15 (75)	7 (100)	8 (62)	0.08
Intensive care unit admission	5 (25)	4 (57)	1 (8)	0.03
Oxygen therapy	14 (70)	7 (100)	7 (54)	0.04
Noninvasive ventilation	6 (30)	5 (71)	1 (8)	< 0.01
Invasive ventilation	3 (15)	3 (42)	0 (0)	0.03
Length of hospital stay	13.5 ± 9.7	13.4 ± 9.1	13.6 ± 9.8	0.46
Post acute COVID-19 follow-up
Days since symptom onset	64.3 ± 12.3	60.8 ± 12.7	66.2 ± 12.2	0.36
Days since hospital discharge	36.1 ± 12.9	37.8 ± 11.7	36.0 ± 10.2	0.54
Persistent symptoms
Dyspnea	17 (85)	5 (71)	12 (92)	0.27
Joint pain	6 (30)	1 (14)	5 (38)	0.04
Dysgeusia	5 (25)	1 (14)	4 (31)	0.14
Sore Throat	5 (25)	1 (14)	4 (31)	0.14
Anosmia	4 (20)	1 (14)	3 (23)	0.56
Rhinitis	2 (10)	1 (14)	1 (14)	0.58
BMI (Kg/m²)	22.1 ± 3.8	23.4 ± 2.2	21.3 ± 4.3	0.25
Hang grip strength (Kg)	24.0 ± 6.0	29.5 ± 4.5	21.0 ± 4.4	<0.001
Skeletal mass index (Kg/m²)	7.25 ± 1.00	8.35 ± 0.69	6.65 ± 0.52	<0.001
Albumin (g/dl)	4.11 ± 0.32	3.80 ± 0.25	4.25 ± 0.25	0.38
Vitamin D (ng/dl)	23.9 ± 9.2	20.9 ± 5.5	25.2 ± 10.3	0.39
Quality of life (EuroQol scale)	68.0 ± 15.9	77.4 ± 11.1	63.0 ± 16.2	0.05

* Data are given as number (percent) for persistent symptoms and acute COVID-19 characteristics; for all the other variables, means ±SD are reported.

BMI: Body mass index; BP: blood pressure

Quality of life was assessed using EuroQol visual analog scale, ranging from 0 (worst imaginable health) to 100 (best imaginable health)

Table 2: Characteristics of study population according to gender *