Examples of Nutrients Gaining Acceptance as Conditionally Essential in Certain Disease States |
CONDITION |
NUTRIENT |
Phase 1 Defic |
Phase 2 Defic |
Phase 3 Defic |
Parkinson’s |
Q10 |
Synthesized by HMG-CoA reductase (commonly inhibited by statins) |
SpectaCell FIA 4-fold risk of Q10 defic [11]. |
TBD: Myalgia?
Fatigue?
Weakness?
Cardiomyopathy? |
Parkinson’s |
Glutathione |
Synthesized on demand, not stored. |
40% depletion of nigral GSH at diagnosis;
GSH defic leads to inflammation, ROS, mitochondrial dysfunction |
GSH depletion associated with aging, GSH progression
|
Parkinson’s
See also:
Epilepsy
Mental illness
Tics
Addiction
ADHD
Migraine
Alzheimer’s
MS, ALS, HD |
Lithium |
Not stored. Typically obtained |
Ecological studies from 1970s show municipal supply assoic with body level. Depletion in rainy regions, highest in desert. *To-do: Repeat in WA |
Low Li associated with psychosis, depression, aggressive behavior, and suicide. Calls in the literature for more research and Li the water supply of depleted regions have been ignored. *To-do: Study Li repletion among those deficient. Reverse feeding study. |
Parkinson’s
See also:
IBS, IBD
Autoimmune disease
Atopia |
Probiotics |
|
Following probiotic supplementation, improvement in normal stools, bloat, and pain in constipated PD patients
[8]. |
Constipation affects 80% of PD pts. Individuals who have a bowel mov. every other day are 4x as likely to develop PD as those who have 2+ bowel mov./ d [10]. |
Parkinosn’s
See also:
Alzheimer’s
Epilepsy
MS |
Vitamin D |
|
Levels lower in PD than healthy elderly or AD [11, 7]. |
PD associated with osteoporosis, balance, weakness, depression- all also assoc with D.
Higher vit D assoc with better mood and cognitive function in PD [9]. |
Metabolic syndrome |
Glycine |
|
[5] |
|
Coronary Heart Disease |
DHA + EPA |
|
Immune dysfunction
[Calder 2010] |
Cognitive decline [Calder 2010] |
|
Flavonoids |
|
Inflammation |
CVD, obesity, neurodegeneration, neuronal hyperexcitability: tics, seizures, ADD, etc. |