Examples of Nutrients Gaining Acceptance as Conditionally Essential in Certain Disease States

CONDITION

NUTRIENT

Phase 1 Defic

Phase 2 Defic

Phase 3 Defic

Parkinson’s

Q10

Synthesized by HMG-CoA reductase (commonly inhibited by statins)

SpectaCell FIA 4-fold risk of Q10 defic [11].

TBD: Myalgia?
Fatigue?
Weakness?
Cardiomyopathy?

Parkinson’s

Glutathione

Synthesized on demand, not stored.

40% depletion of nigral GSH at diagnosis;
GSH defic leads to inflammation, ROS, mitochondrial dysfunction

GSH depletion associated with aging, GSH progression

Parkinson’s

See also:
Epilepsy
Mental illness
Tics
Addiction
ADHD
Migraine
Alzheimer’s
MS, ALS, HD

Lithium

Not stored. Typically obtained

Ecological studies from 1970s show municipal supply assoic with body level.  Depletion in rainy regions, highest in desert. *To-do: Repeat in WA

Low Li associated with psychosis, depression, aggressive behavior, and suicide.  Calls in the literature for more research and Li the water supply of depleted regions have been ignored. *To-do: Study Li repletion among those deficient. Reverse feeding study.

Parkinson’s

See also:
IBS, IBD
Autoimmune disease
Atopia

Probiotics

Following probiotic supplementation, improvement in normal stools, bloat, and pain in constipated PD patients
[8].

Constipation affects 80% of PD pts.  Individuals who have a bowel mov. every other day are 4x as likely to develop PD as those who have 2+ bowel mov./ d [10].

Parkinosn’s

See also:
Alzheimer’s
Epilepsy
MS         

Vitamin D

Levels lower in PD than healthy elderly or AD [11, 7].

PD associated with osteoporosis, balance, weakness, depression- all also assoc with D.
Higher vit D assoc with better mood and cognitive function in PD [9].

Metabolic syndrome

Glycine

[5]

Coronary Heart Disease

DHA + EPA

Immune dysfunction
[Calder 2010]

Cognitive decline [Calder 2010]

Flavonoids

Inflammation

CVD, obesity, neurodegeneration, neuronal hyperexcitability: tics, seizures, ADD, etc.