Figure 1 Pattern of Cannabis sativa L. var. Bedrocan (a) and one of unknown origin (b).The 12 signals used for detection of cannabis Consumption in breath are numbered and 2 exemplary differences are indicated by a red frame.

Figure 2GC-IMS signal pattern of Cannabis sativa L. var. Bedrocan: headspace of a dried sample (a) and after smoking (0.5 g) by V1 (b).

Figure 3GC-IMS signal intensity of one particular Cannabis sativa L. biomarkers (peak no. 1 as indicated in Fig. 1a) overtime before () and after smoking () (0.5g).

Figure 4Pattern of Cannabis sativa L. var. Bedrocanafter smoking 0.5 g (a) and after eating 1 kg of Daucus carota by V1 (b), the red circle indicates the presence of caryophyllenexpoxid.

Figure 5 The mobile GC-IMS IONdrug with ~ 8kg incl. a battery for 4 h autonomous operation.

Figure 6 Exemplary screenshots of a complete run of Cannabis consumption detection in exhaled breath.

Volunteer 1

time after cannabis consumption (min)

THC (ng/mL)

11-OH-THC (ng/mL)

THC-COOH (ng/mL)

0

n.d.

n.d.

n.d.

26

8,0

0,33

4,3

36

6,1

0,37

4,7

46

5,1

0,34

4,1

56

4,4

0,36

3,6

66

4,7

0,42

3,6

106

3,4

0,40

3,2

136

1,9

0,32

3,3

316

0,30

n.d.

2,6

406

n.d.

n.d.

n.d.

Table 1 Concentrations in a toxicokinetic blood profile of 2 volunteers recorded by GC-MS.