Continue with the treatment. Increase the frequency of monitoring to 2-3 times per week
Moderate
999-500 / microL
Stop treatment. Consult with the hematologist. Daily monitoring Lmtil the count rises> 1000 I microL where restarting clozapi ne could be
considered
Severe
<500 / microL
Stop treatment. Consult with the hematologist.
Reintroduction of treatment is not
recom mended unless the benefit outweighs the risks and with the agreement of
the hematologist.
Table 1: Recommendations for the management of clozapine-associated neutropenia
Tables at a glance