Table 1: Demographic and clinical characteristics of the subjects (n=100).

Variables	Mean (s.d.)/n(%)
Age	69.0±8.7
Sex(male)	62(62.0%)
Education years	5.1±3.6
Hypertension	71(71.0%)
Diabetes	32(32.0%)
Smoking history	51(51.0%)
Prior stroke	11(11.0%)
NIHSS on admission	4.5±3.1
MMSE	25.8 (3.2)
GDS	4.5 (3.9)
Intracranial volume (cm3)	1446.82 (173.62)
Grey matter volume (cm3)	574.12 (75.31)
Grey matter / intracranial volume	0.397
Hippocampal volume (cm3)* Amygdala volume (cm3)*	7.36 (0.91) 2.81 (0.42)
White matter lesions volume (cm3)	5.44 (4.22)

NIHSS=the National Institutes of Health Stroke Scale; BI=Barthle index; MMSE=Mini-Mental State Examination; GDS= Geriatric Depression Scale. * The sum of left and right

Table 2: Clinical and imaging characteristics between smaller and larger volume groups in term of hippocampus, amygadala and cortical grey matter.

	Hippocampus		Amygdala		Cortical grey matter
	smaller n=50	larger n=50	smaller n=50	larger n=50	smaller n=50	larger n=50
*Clinical variables*
age	71.9±9.3‡	66.1±7.4	71.9±8.6‡	66.1±8.2	71.5±7.9‡	66.4±9.1
sex(male)	38(76.0%)‡	24(48.0%)	34(68.0%)	28(56.0%)	37(74.0%)†	25(50.0%)
education years	5.1±3.5	5.2±3.6	5.1±3.6	5.1±3.5	5.2±3.2	5.0±3.9
hypertension	34(68.0%)	37(74.0%)	33(66.0%)	38(76.0%)	35(70.0%)	36(72.0%)
diabetes mellitus	17(34.0%)	15(30.0%)	14(28.0%)	18(36.0%)	17(34.0%)	15(30.0%)
hyperlipidemia	28(56.0%)	27(54.0%)	25(50.0%)	30(60.0%)	24(48.0%)	31(62.0%)
ischemic heart disease	2(4.0%)	4(8.0%)	2(4.0%)	4(8.0%)	4(8.0%)	2(4.0%)
previous stroke	7(14.0%)	4(8.0%)	7(14.0%)	4(8.0%)	6(12.0%)	5(10.0%)
smoking history	30(60.0%)*	21(42.0%)	28(56.0%)	23(46.0%)	30(60.0%)*	21(42.0%)
MMSE	25.6±3.5	26.0±3.1	25.7±3.2	25.9±3.3	25.9±3.3	25.7±3.2
GDS	4.2±3.9	4.8±3.8	4.3±4.1	4.7±3.6	4.3±3.9	4.6±3.8
*Imaging variables*
no of old lacunes	0.9±1.6	0.6±1.0	0.8±1.6	0.6±1.0	0.8±1.4	0.6±1.3
no of old infarcts	1.0±1.6	0.7±1.1	1.0±1.6	0.8±1.1	1.0±1.4	0.8±1.3
Std. volume of old infarcts	1.2±3.2*	0.1±0.1	1.0±2.2	0.5±2.4	1.0±3.0†	0.3±1.2
Std. WMLs volume	5.1±3.5‡	2.4±1.7	4.9±3.6‡	2.6±1.8	4.0±2.1‡	3.5±3.8
presence of CMBs	14(28.0%)	12(24.0%)	12(24.0%)	14(28.0%)	16(32.0%)	10(20.0%)
no of CMBs	1.3±2.9	0.9±3.2	1.2±2.9	0.9±3.1	1.3±2.8	0.9±3.2

*P< 0.1; †P< 0.05; ‡P< 0.01. MMSE= Mini-mental Status Examination; GDS= Geriatric Depression Scale; Std. WMLs volume = Standardized white matter lesions volume; CMBs= cerebral microbleeds.

Table 3: Logistic regression analysis of smaller volumes of the hippocampus, amygdale and cortical grey matter

Variables	Smaller hippocampal		Smaller Amygdala		Smaller CGM volume
	P	OR (95%C.I.)	P	OR (95%C.I.)	P	OR (95%C.I.)
Age	0.098	1.060 (0.989-1.135)	0.033	1.062 (1.005-1.123)	<0.001	1.123 (1.055-1.195)
Sex(male)	0.004	5.714 (1.754-18.519)	--	--	0.001	6.173 (2.105-18.182)
Std. WMLs volume	0.004	1.869 (1.226-2.849)	0.070	1.042 (0.997-1.090)	0.317	0.903 (0.740-1.103)
Old infarcts volume	0.139	2.919 (0.706-12.074)	--	--	0.204	1.151 (0.926-1.431)
Smoking history	0.574	0.701 (0.220-2.230)	--	--	0.661	0.795 (0.285-2.217)

CGM= Cortical grey matter; Std. WMLs volume = Standardized white matter lesions volume; OR=odds ratio.