1Al-Shammri S, Rawoot P, Azizieh F, AbuQoora A,
Hanna M, et al. (2004) Th1/Th2 cytokine patterns and clinical
profiles during and after pregnancy in women with multiple
sclerosis. J Neurol Sci 222: 21-27.
2Annunziato F, and Maggi L (2017) Methods in
Molecular Biology. New York: Springer Science+Business
Media.
3Apelgren LD, Bailey DL, Fouts RL, Short N, Evans GF,
et al. (1996) The effect of a selective estrogen receptor modulator
on the progression of spontaneous autoimmune disease in MRL
lpr/lpr. mice. Cellular Immunology 173: 55-63.
4Baaten BJ, Li CR, Deiro MF, Lin MM, et al. (2010)
CD44 regulates survival and memory development in Th1 cells.
Immunity. Immunity 32: 104-115.
5Bagnoli F, Oliveira VM, Silva MA, Taromaru GC, et al.
(1992) The interaction between aromatase, metalloproteinase 2,9
and CD44 in breast cancer. Rev Assoc Med Bras 56: 472-477.
6Bebo BF, Fyfe-Johnson A, Adlard K, Beam AG, et al.
(2001) Low- dose estrogen therapy ameliorates experimental
autoimmune encephalomyelitis in two different inbred mouse
strains. Journal of Immunology 166: 2080-2089.
7Benedek G, Zhang J, Nguyen H, Kent G, Seifert HA, et
al. (2017) Estrogen protection against EAE modulate the
microbiota and mucosal-associated regulatory cells. J
Neuroimmunol 310: 51-59.
8Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, et al.
(2006) Reciprocal developmental pathways for the generation of
pathogenic effector TH17 and regulatory T cells. Nature 441:
235-238.
9Bitan M, Weiss L, Reibstein I, Zeira M, Fellig Y, Slavin S,
et al. (2010) Heparanase upregulates Th2 cytokines, ameliorating
experimental autoimmune encephalitis. Mol Immunol 47: 1890-
1898.
10Bollyky PL, Falk BA, Long SA, Preisinger A, et al.
(2009) CD44 costimulation promotes FoxP3+ regulatory T cell
persistence and function via the production of IL-2, IL-10, and
TGF-beta. Immunol 183: 2232– 2241.
11Bollyky PL, Lord JD, Masewicz SA, Evanko SP, et al.
(2007) Cutting edge: high molecular weight hyaluronan
promotes the suppressive effects of CD4 CD25 regulatory T
cells. J Immunol 179: 744–747.
12Bourguignon LY, Gilad E, Rothman K, and Peyrollier
K (2005) Hyaluronan-CD44 interaction with IQGAP1 promotes
Cdc42 and ERK signaling, leading to actin binding, Elk-
1/estrogen receptor transcriptional activation, and ovarian cancer
progression. J Biol Chem 280: 11961-11972.
13Chitrala KN, Guan H, Singh NP, Busbee B, Gandy A, et
al. (2017) CD44 deletion leading to attenuation of experimental
autoimmune encephalomyelitis results from alterations in gut
microbiome in mice. Eur J Immunol 47: 1188-1199.
14Elloso MM, Phiel K, Henderson RA, Harris HA, and
Adelman SJ (2005) Suppression of experimental autoimmune
encephalomyelitis using estrogen receptor-selective ligands. J
Endocrinol 185: 243-252.
15Esparza J, Kruse M, Lee J, Michaud M, and Madri JA (2004)
MMP-2 null mice exhibit an early onset and severe experimental
autoimmune encephalomyelitis due to an increase in MMP-9 expression
and activity. FASEB J 18: 1682-1691.
16Fang YJ, Zhang L, Wu XJ, Lu ZH, Li JB, Ou QJ, et al. (2012)
Impact of ERβ and CD44 expression on the prognosis of patients
with stage II colon cancer. Tumour Biol 33: 1907-1914.
17Figueiredo AS, and Schumacher A (2016) The T helper type
17/regulatory T cell paradigm in pregnancy. Immunology 148:
13-21.
18Filippi M, Bar-Or A, Piehl F, Preziosa P, Solari A, et al. (2018)
Multiple sclerosis. Nat Rev Dis Primers 4: 43.
19Firan M, Dhillon S, Estess P, and Siegelman MH (2006) Suppressor
activity and potency among regulatory T cells are
discriminated by functionally active CD44. BLOOD 107: 619–
627.
20Flynn K, Michaud M, Canosa S, and Madri JA (2013) CD44
Regulates Vascular Endothelial Barrier Integrity via a PECAM-1
Dependent Mechanism. Angiogenesis 16: 689-705.
21Flynn K, Michaud M, and Madri JA (2013) CD44 Deficiency
Contributes to Enhanced Experimental Autoimmune
Encephalomyelitis: A Role in Immune Cells and Vascular Cells
of the Blood Brain Barrier. Amer J Pathol 182: 1322-1336.
22Fuentes N, Silveyra P (2019) Estrogen receptor signaling
mechanisms. Adv Protein Chem Struct Biol 116: 135-170.
23Glatigny S, and Bettelli E (2018) Experimental Autoimmune
Encephalomyelitis (EAE) as Animal Models of Multiple Sclerosis
(MS). Cold Spring Harb Perspect Med 8.
24Gonzalez GA, Hofer MP, Syed YA, Amaral AI, et al. (2016)
Tamoxifen accelerates the repair of demyelinated lesions in the
central nervous system. Sci Rep 6: 31599.
25Guan H, Nagarkatti PS, and Nagarkatti M (2011) CD44
Reciprocally regulates the differentiation of encephalitogenic
Th1/ Th17 and Th2/regulatory T cells through epigenetic
modulation involving DNA methylation of cytokine gene
promoters, thereby controlling the development of experimental
autoimmune en- cephalomyelitis. J Immunol 186.
26Guan H, Nagarkatti PS, and Nagarkatti M (2009) Role of
CD44 in the differentiation of Th1 and Th2 cells: CD44-defi-ciency enhances the development of Th2 effectors in
response to sheep RBC and chicken ovalbumin. J Immunol 183:
172-180.
27Haghmorad D, Amini AA, Mahmoud iMB, et al. (2014)
Pregnancy level of estrogen attenuates experimental
autoimmune encephalomyelitis in both ovariectomized and
pregnant C57BL/6 mice through the expansion of Treg and Th2
cells. J Neuroimmunol 277: 85-95.
28Hofstetter H, Gold R, and Hartung HP (2009) Th17 cells in
MS and experimental autoimmune encephalomyelitis. Int MS J
16: 12-18.
29Ibrahim EM, Stewart RL, Corke K, et al. (2006) Upregulation
of CD44 expression by interleukins [1, 4, and 13] transforming
growth factor-beta1, estrogen, and progestogen in human
cervical adenocarcinoma cell lines. Int J Gynecol Cancer 16:
1631- 1642.
30Javadian A, Salehi E, Bidad K, Sahraian MA, and Izad M
(2014) Effect of estrogen on Th1, Th2 and Th17 cytokines production
by proteolipid protein and PHA activated peripheral
blood mononuclear cells isolated from multiple sclerosis
patients. Arch Med Res 45: 177- 182.
31Katoh S, Kaminuma O, Hiroi T, Mori A, Ohtomo T, et al.
(2011) CD44 is critical for airway accumulation of antigenspecific
Th2, but not Th1, cells induced by antigen challenge in
mice. European Journal of Immunology 41: 3198-3320.
32Kebir H, Kreymborg K, Ifergan I, Dodelet-Devillers A, et al.
(2007) Human TH17 lymphocytes promote blood-brain barrier
disruption and central nervous system inflammation. Nat Med
13: 1173-1175.
33Liu T, Soong L, Liu G, König R, and Chopra AK (2009) CD44
expression positively correlates with Foxp3 expression and
suppressive function of CD4+ Treg cells. Biol Direct 4: 40.
34Macdonald DC, Leir SH, Brooks C, et al. (2003) CD44 isoform
expression on colonic epithelium mediates lamina propria
lymphocyte adhesion and is controlled by Th1 and Th2
cytokines. Eur J Gastroenterol Hepatol 15: 1101-1110.
35Mills EA, Ogrodnik MA, Plave A, and Mao-Draayer Y (2018)
Emerging Understanding of the Mechanism of Action for
Dimethyl Fumarate in the Treatment of Multiple Sclerosis. Front
Neurol 9: 5.
36Morales LB, Loo KK, Liu HB, Peterson C, et al. (2006)
Treatment with an estrogen receptor alpha ligand is
neuroprotective in experimental autoimmune encephalomyelitis.
J Neurosci 26: 6823-6683.
37Nilsson ME, Vandenput L, Tivesten Å, Norlén AK, et al.
(2015) Measurement of a Comprehensive Sex Steroid Profile in
Rodent Serum by High-Sensitive Gas Chromatography-Tandem
Mass Spectrometry. Endocrinology 156: 2492-2502.
38Nishimura T, Katoh S, Mori A, Ohtomo T, et al. Critical role
of CD44 in antigen-induced Th2- but not Th17-mediated murine
airway inflammation. Allergol Int 65: S59-61.
39Papenfuss TL, Rogers CJ, Gienapp I, et al. (2004) Sex
differences in experimental autoimmune encephalomyelitis in
multiple murine strains. J Neuroimmunol 150: 59-69.
40Polanczyk MJ, Hopke C, Huan J, Vandenbark AA, and Offner
H (2005) Enhanced FoxP3 expression and Treg cell function in
pregnant and estrogen-treated mice. J Neuroimmunol 170: 85-
92.
41Ponta H, Sgerman L, and Herrlich PA (2003) From adhesion
molecules to signaling regulators. Nature Reviews Molecular
Cell Biology 4: 33-45.
42Reddy J, Waldner H, Zhang X, Illes Z, et al. (2005) Cutting
edge: CD4+CD25+ regulatory T cells contribute to gender
differences in susceptibility to experimental autoimmune
encephalomyelitis. J Immunol 175: 5591-5595.
43Seifert HA, Benedek G, Nguyen H, Kent G, et al. (2017)
Estrogen protects both sexes against EAE by promoting
common regulatory cell subtypes independent of endogenous
estrogen. Metab Brain Dis 32: 1747-1754.
44Sekiya T, and Yoshimura A (2016) In Vitro Th Differentiation
Protocol. Methods Mol Biol183-191.
45Shi J, Chen Y, Chen W, Tang C, Zhang H, et al. (2018)
Isobavachalcone sensitizes cells to E2-induced paclitaxel
resistance by down-regulating CD44expression in ER+ breast
cancer cell. J Cell Mol Med 22: 5220-5230.
46Sinha S, Kaler LJ, Proctor TM, et al. (2008) IL-13- mediated
gender difference in susceptibility to autoimmune
encephalomyelitis. J Immunol 180: 2679-2685.
47Tiwari-Woodruff S, and Voskuhi RR (2009) Neuroprotective
and anti-inflammatory effects of estrogen receptor ligand
treatment in mice. Journal of the Neurological Sciences 286: 81-
85.
48Tsuneki M, and Madri JA (2014) Adhesion Molecule-
Mediated Hippo Pathway Modulates Hemangioendothelioma
Cell Behavior. Mol Cell Biol 34: 4485-4499.
49Tsuneki M, and Madri JA (2015) CD44 influences fibroblast
behaviors via modulation of cell- cell and cell-matrix
interactions, affecting Survivin and Hippo pathways. Journal of
Cellular Physiology 231: 731-743.
50Tsuneki M, and Madri JA (2014) CD44 regulation of endotheand VE-cadherin expression. J Biol Chem: 5357-5370.
51Valéra MC, Fontaine C, Dupuis M, et al. (2018) Towards
optimization of estrogen receptor modulation in medicine.
Pharmacol Ther 189:123-129
52Weber JD, Smith E, Berry-Kravis E, et al. (2019) Voice of
People with Fragile X Syndrome and Their Families: Reports
from a Survey on Treatment Priorities. Brain Sci 92: pii: E18.
53Wittig BM, Johansson B, Zöller M, Schwärzler C, et al. (2000)
Abrogation of experimental colitis correlates with increased
apoptosis in mice deficient for CD44variant exon 7 (CD44v7). J
Exp Med 191: 2053-2064.
54Wittig BM, Stallmach A, Zeitz M, and Günthert U (2003)
Functional involvement of CD44 variant 7 in gut immune response.
Pathobiology 70: 184-189.
55Wu Q, Wang Q, Mao G, Dowling CA, et al. (2017) Dimethyl
Fumarate Selectively Reduces Memory T Cells and Shifts the
Balance between Th1/Th17 and Th2 in Multiple Sclerosis
Patients. J Immunol 198: 3069-3080.
56Xue L, Liang H, and Jiang X (2011) Up-regulation of CD44
expression by interleukin-13 in a murine model of asthma. Mol
Med Rep 4: 1233-1237.
57Yakubenko VP, Lobb RR, Plow EF, and Ugarova TP (2000)
Differential induction of gelatinase B (MMP-9) and gelatinase A
(MMP-2) in T lymphocytes upon alpha (4) beta (1)-mediated
adhesion to VCAM-1 and the CS-1 peptide of fibronectin. Exp
Cell Res 260: 73-84.
58Yang M, Liu Y, Ren G, Shao Q, Gao W, et al. (2015) Increased
expression of surface CD44 in hypoxia-DCs skews helper T cells
toward a Th2 polarization. Sci Rep 5: 13674.