Figure 1: Peaks of size distribution of DEPs were detected by Zetasizer Nano-ZS system. (A) Size vs. Number and (B) Size vs. Volume

Figure 2: Gender differences in the elevated plus maze navigation by the male (M) and female (F) animals (A) Percentage of the entered open arms by the different groups of mice during the plus maze searching. While the DEPs exposure led a marked decrease in entering the open arms in all exposure groups. (B) Percentage of the duration of stay in the entered open arms during the plus maze navigation. The male and female animals displayed a considerable decrease in the time of the open arm steering. Results are represented as mean ± SEM with n=10 in each group. Asterisks indicate significant differences between genders compared with the control mice.*P < 0.05, **P < 0. 01, ***P < 0.001

Figure 3: Gender differences in effects of sub-chronic DEPs exposure on enhanced immobility in the (A) forced swim task. Bar diagram repre? senting the day-dependent study on the effects of DEPs exposure, increased the duration of time spent floating and immobility (in second) of male (M) and female (F) mice in forced swim test which is consistent with a depressive-like state. (B) DEPs exposure mice also reduced the latency to first float (in second) demonstrating rapid attainment of behavioral despair in male (M) and female (F) mice. Results are represented as mean ± SEM with n=10 in each group.Asterisks indicate significant differences between genders compared with the control mice. *P < 0.05, **P < 0. 01, ***P < 0.001