
Variable	Total	Both AQT and CRT index normal	Only AQT abnormal	Only CRT index abnormal	Both AQT and CRT index abnormal
Total	74	34	6	25	9
Men, n (%)	52 (70)	24 (71)	3 (50)	19 (76)	6 (67)
Mean age (IQR)	49 (43-54)	46 (42-53)	47 (41-53)	51 (46-58)	49 (47-50)
Highest education completed
Basic schooling, n (%)	23 (31)	11 (32)	0 (0)	9 (36)	3 (33)
Short education, n (%)	28 (38)	10 (29)	3 (50)	9 (36)	6 (67)
Tertiary education, n (%)	23 (31)	13 (38)	3 (50)	7 (28)	0 (0)
Employed, n (%)	15 (20)	11 (32)	0 (0)	2 (8)	2 (22)
Years of alcohol dependence, median (IQR)	14 (6-21)	13 (10-21)	5 (4-5)	14 (6-19)	19 (13-24)
Days of high alcohol consumption (≥5 drinks/day), median (IQR)a	30 (10-31)	20 (8-30)	30 (7-30)	30 (25-30)	30 (20-30)
Weekly alcohol intake (drinks/week), median (IQR)a	100 (50-168)	103 (42-140)	67 (35-102)	91 (66-175)	130 (90-210)
Other drug use (cannabis, cocaine or other substances), n (%)	11 (15)	7 (21)	1 (17)	1 (4)	2 (22)
Relapse, n (%)	13 (18)	5 (15)	0 (0)	4 (16)	4 (44)
Use of psychoactive medicine, n (%)	42 (57)	16 (47)	6 (100)	13 (52)	7 (78)
Psychiatric disorders, n (%)	32 (43)	15 (44)	1 (17)	13 (52)	3 (33)

Table 1: Baseline characteristics of study population, normal/abnormal baseline tests of the Quick Test of Cognitive Speed (AQT) and Continuous reaction time (CRT) index

IQR, interquartile range
^a30 days before start of treatment

	Linear regression (beta, 95%CI, p-value)	Test for interaction
All patients (N=191)	β = -3.3, 95%CI: -5.5; -1.2, p>0.05
By years of alcohol dependence
<14 years (N=113):	β = -3.0, 95%CI: -5.8; -0.3, p=0.03	p=0.80
≥14 years (N=78):	β = -3.5, 95%CI: -6.6; -0.4, p=0.03	p=0.80
By days of high alcohol use (≥5 drinks/day) last 30 days
<30 days (N=103)	β = -3.7, 95%CI: -5.8; -1.6, p>0.05	p=0.65
≥30 days (N=88)	β = -2.6, 95%CI: -6.8; 1.6, p=0.22	p=0.65
By other drug use
No other drug use (N=166)	β = -3.1, 95%CI: -5.2; -1.1, p>0.05	p=0.84
Other drug use (N=25)	β = -3.0, 95%CI: -9.4; 3.5, p=0.37	p=0.84
By relapse
No relapse (N=155)	β = -3.8, 95%CI: -5.9; -1.7, p>0.05	p=0.59
At least one relapse (N=36)	β = -2.4, 95%CI: -7.3; 2.5, p=0.33	p=0.59
By use of psychoactive medicine
No use of psychoactive medicine (N=88)	β = -3.3, 95%CI: -5.7; -0.9, p>0.05	p=0.81
Use of at least one psychoactive medicine (N=103)	β = -3.5, 95%CI: -6.7; -0.2, p>0.05	p=0.81
By psychiatric diagnosis
No psychiatric diagnosis (N=106)	β = -2.6, 95%CI: -5.0; -0.2, p>0.05	p=0.41
At least one psychiatric diagnosis (N=85)	β = -4.6, 95%CI: -8.5; -0.6, p>0.05	p=0.41

	Linear regression (beta, 95%CI, p-value)	Test for interaction
All patients (N=191)	β = 0.09, 95%CI: -0.04; 0.21, p=0.16
By years of alcohol dependence
<14 years (N=113):	β = 0.25, 95%CI: 0.09; 0.43, p=0.003	p=0.01
≥14 years (N=78):	β = -0.05, 95%CI: -0.20; 0.09, p=0.45	p=0.01
By days of high alcohol use (≥5 drinks/day) last 30 days
<30 days (N=103)	β = 0.03, 95%CI: -0.15; 0.20, p=0.76	p=0.26
≥30 days (N=88)	β = 0.17, 95%CI: -0.004; 0.34, p=0.06	p=0.26
By other drug use
No other drug use (N=166)	β = 0.10, 95%CI: -0.03; 0.24, p=0.13	p=0.59
Use of at least one drug (N=25)	β = 0.01, 95%CI: -.27; 0.29, p=0.92	p=0.59
By relapse
No relapse (N=155)	β = 0.11, 95%CI: -0.05; 0.26, p=0.19	P=0.83
At least one relapse (N=36)	β = 0.11, 95%CI: -0.09; 0.30, p=0.27	P=0.83
By use of psychoactive medicine
No use of psychoactive medicine (N=88)	β = 0.17, 95%CI: -0.05; 0.39, p=0.12	P=0.21
Use of at least one psychoactive medicine (N=103)	β = 0.01, 95%CI: -0.12; 0.14, p=0.85	P=0.21
By psychiatric diagnosis
No psychiatric diagnosis (N=106)	β = 0.01, 95%CI: -0.11; 0.13, p=0.85	P=0.08
At least one psychiatric diagnosis (N=85)	β = 0.22, 95%CI: 0.01; 0.44, p=0.04	P=0.08

Tables at a glance

Figures at a glance