Figure 1: Test values for AQT and CRT index during the study period
Variable |
Total |
Both AQT and CRT index normal |
Only AQT abnormal |
Only CRT index abnormal |
Both AQT and CRT index abnormal |
Total |
74 |
34 |
6 |
25 |
9 |
Men, n (%) |
52 (70) |
24 (71) |
3 (50) |
19 (76) |
6 (67) |
Mean age (IQR) |
49 (43-54) |
46 (42-53) |
47 (41-53) |
51 (46-58) |
49 (47-50) |
Highest education completed |
|
|
|
|
|
Basic schooling, n (%) |
23 (31) |
11 (32) |
0 (0) |
9 (36) |
3 (33) |
Short education, n (%) |
28 (38) |
10 (29) |
3 (50) |
9 (36) |
6 (67) |
Tertiary education, n (%) |
23 (31) |
13 (38) |
3 (50) |
7 (28) |
0 (0) |
Employed, n (%) |
15 (20) |
11 (32) |
0 (0) |
2 (8) |
2 (22) |
Years of alcohol dependence, median (IQR) |
14 (6-21) |
13 (10-21) |
5 (4-5) |
14 (6-19) |
19 (13-24) |
Days of high alcohol consumption (≥5 drinks/day), median (IQR)a |
30 (10-31) |
20 (8-30) |
30 (7-30) |
30 (25-30) |
30 (20-30) |
Weekly alcohol intake (drinks/week), median (IQR)a |
100 (50-168) |
103 (42-140) |
67 (35-102) |
91 (66-175) |
130 (90-210) |
Other drug use (cannabis, cocaine or other substances), n (%) |
11 (15) |
7 (21) |
1 (17) |
1 (4) |
2 (22) |
Relapse, n (%) |
13 (18) |
5 (15) |
0 (0) |
4 (16) |
4 (44) |
Use of psychoactive medicine, n (%) |
42 (57) |
16 (47) |
6 (100) |
13 (52) |
7 (78) |
Psychiatric disorders, n (%) |
32 (43) |
15 (44) |
1 (17) |
13 (52) |
3 (33) |
Table 1: Baseline characteristics of study population, normal/abnormal baseline tests of the Quick Test of Cognitive Speed (AQT) and Continuous reaction time (CRT) index
IQR, interquartile range
a30 days before start of treatment
Variable |
Total |
Both AQT and CRT index normal |
Only AQT abnormal |
Only CRT index abnormal |
Both AQT and CRT index abnormal |
Total |
74 |
34 |
6 |
25 |
9 |
Men, n (%) |
52 (70) |
24 (71) |
3 (50) |
19 (76) |
6 (67) |
Mean age (IQR) |
49 (43-54) |
46 (42-53) |
47 (41-53) |
51 (46-58) |
49 (47-50) |
Highest education completed |
|
|
|
|
|
Basic schooling, n (%) |
23 (31) |
11 (32) |
0 (0) |
9 (36) |
3 (33) |
Short education, n (%) |
28 (38) |
10 (29) |
3 (50) |
9 (36) |
6 (67) |
Tertiary education, n (%) |
23 (31) |
13 (38) |
3 (50) |
7 (28) |
0 (0) |
Employed, n (%) |
15 (20) |
11 (32) |
0 (0) |
2 (8) |
2 (22) |
Years of alcohol dependence, median (IQR) |
14 (6-21) |
13 (10-21) |
5 (4-5) |
14 (6-19) |
19 (13-24) |
Days of high alcohol consumption (≥5 drinks/day), median (IQR)a |
30 (10-31) |
20 (8-30) |
30 (7-30) |
30 (25-30) |
30 (20-30) |
Weekly alcohol intake (drinks/week), median (IQR)a |
100 (50-168) |
103 (42-140) |
67 (35-102) |
91 (66-175) |
130 (90-210) |
Other drug use (cannabis, cocaine or other substances), n (%) |
11 (15) |
7 (21) |
1 (17) |
1 (4) |
2 (22) |
Relapse, n (%) |
13 (18) |
5 (15) |
0 (0) |
4 (16) |
4 (44) |
Use of psychoactive medicine, n (%) |
42 (57) |
16 (47) |
6 (100) |
13 (52) |
7 (78) |
Psychiatric disorders, n (%) |
32 (43) |
15 (44) |
1 (17) |
13 (52) |
3 (33) |
Appendix 1, Table A: Characteristic of patients with incomplete follow-up and odds ratio for not participating in test 3 by sex, years of alcohol dependence and relapse
|
Linear regression (beta, 95%CI, p-value) |
Test for interaction |
All patients (N=191) |
β = -3.3, 95%CI: -5.5; -1.2, p>0.05 |
|
By years of alcohol dependence |
||
<14 years (N=113): |
β = -3.0, 95%CI: -5.8; -0.3, p=0.03 |
p=0.80 |
≥14 years (N=78): |
β = -3.5, 95%CI: -6.6; -0.4, p=0.03 |
|
By days of high alcohol use (≥5 drinks/day) last 30 days |
||
<30 days (N=103) |
β = -3.7, 95%CI: -5.8; -1.6, p>0.05 |
p=0.65 |
≥30 days (N=88) |
β = -2.6, 95%CI: -6.8; 1.6, p=0.22 |
|
By other drug use |
||
No other drug use (N=166) |
β = -3.1, 95%CI: -5.2; -1.1, p>0.05 |
p=0.84 |
Other drug use (N=25) |
β = -3.0, 95%CI: -9.4; 3.5, p=0.37 |
|
By relapse |
||
No relapse (N=155) |
β = -3.8, 95%CI: -5.9; -1.7, p>0.05 |
p=0.59 |
At least one relapse (N=36) |
β = -2.4, 95%CI: -7.3; 2.5, p=0.33 |
|
By use of psychoactive medicine |
||
No use of psychoactive medicine (N=88) |
β = -3.3, 95%CI: -5.7; -0.9, p>0.05 |
p=0.81 |
Use of at least one psychoactive medicine (N=103) |
β = -3.5, 95%CI: -6.7; -0.2, p>0.05 |
|
By psychiatric diagnosis |
||
No psychiatric diagnosis (N=106) |
β = -2.6, 95%CI: -5.0; -0.2, p>0.05 |
p=0.41 |
At least one psychiatric diagnosis (N=85) |
β = -4.6, 95%CI: -8.5; -0.6, p>0.05 |
Appendix 2, Table A: Test results of the Quick Test of Cognitive Speed (AQT) by days since alcohol treatment start, by years of alcohol dependence, by days of high alcohol use last 30 days, by other drug use, by relapse, by use of psychoactive medicine and by psychiatric diagnosis, beta, 95%CI, p-value and test for interaction
|
Linear regression (beta, 95%CI, p-value) |
Test for interaction |
All patients (N=191) |
β = 0.09, 95%CI: -0.04; 0.21, p=0.16 |
|
By years of alcohol dependence |
||
<14 years (N=113): |
β = 0.25, 95%CI: 0.09; 0.43, p=0.003 |
p=0.01 |
≥14 years (N=78): |
β = -0.05, 95%CI: -0.20; 0.09, p=0.45 |
|
By days of high alcohol use (≥5 drinks/day) last 30 days |
||
<30 days (N=103) |
β = 0.03, 95%CI: -0.15; 0.20, p=0.76 |
p=0.26 |
≥30 days (N=88) |
β = 0.17, 95%CI: -0.004; 0.34, p=0.06 |
|
By other drug use |
||
No other drug use (N=166) |
β = 0.10, 95%CI: -0.03; 0.24, p=0.13 |
p=0.59 |
Use of at least one drug (N=25) |
β = 0.01, 95%CI: -.27; 0.29, p=0.92 |
|
By relapse |
||
No relapse (N=155) |
β = 0.11, 95%CI: -0.05; 0.26, p=0.19 |
P=0.83 |
At least one relapse (N=36) |
β = 0.11, 95%CI: -0.09; 0.30, p=0.27 |
|
By use of psychoactive medicine |
||
No use of psychoactive medicine (N=88) |
β = 0.17, 95%CI: -0.05; 0.39, p=0.12 |
P=0.21 |
Use of at least one psychoactive medicine (N=103) |
β = 0.01, 95%CI: -0.12; 0.14, p=0.85 |
|
By psychiatric diagnosis |
||
No psychiatric diagnosis (N=106) |
β = 0.01, 95%CI: -0.11; 0.13, p=0.85 |
P=0.08 |
At least one psychiatric diagnosis (N=85) |
β = 0.22, 95%CI: 0.01; 0.44, p=0.04 |
Appendix 3, Table B: Test results of the continuous reaction time (CRT) index by days since alcohol treatment start, by time, by years of alcohol dependence, by days of high alcohol use last 30 days, by other drug use, by relapse, by use of psychoactive medicine and by psychiatric diagnosis, beta, 95%CI, p-value and test for interaction
The black curves are cubic smooth splines illustrating the association between days since alcohol treatment start and AQT for AD patients with respectively =14 years of alcohol dependence, =30 days of high alcohol use the month before start of treatment, user of other drugs, relapse, use of psychoactive medicine and psychiatric disorders. The grey curves are cubic smooth splines illustrating the association between days since alcohol treatment start and AQT for AD patients with respectively <14 years of alcohol dependence, <30 days of high alcohol use the month before start of treatment, no use of other drugs, no relapse, no use of psychoactive medicine and no psychiatric disorders.
The black curves are cubic smooth splines illustrating the association between days since alcohol treatment start and CRT index for AD patients with respectively =14 years of alcohol dependence, =30 days of high alcohol use the month before start of treatment, user of other drugs, relapse, use of psychoactive medicine and psychiatric disorders. The grey curves are cubic smooth splines illustrating the association between days since alcohol treatment start and CRT index for AD patients with respectively <14 years of alcohol dependence, <30 days of high alcohol use the month before start of treatment, no use of other drugs, no relapse, no use of psychoactive medicine and no psychiatric disorders.
Tables at a glance
Figures at a glance