Figure 1 Kaplan Meier survival function by baseline ART regimen

Variables

 

Non Zidovudine

Zidovudine

 

 

(N=308)

(N=308)

 

 

[n (%)]

[n (%)]

 

 

 

 

Sex

Male

107 (34.74)

108 (34.09)

 

Female

201 (65.26)

200 (64.94)

Educational

No education

80 (25.97)

78

(25.32)

status

Primary education

159 (51.62)

193 (62.66)

 

 

Secondary education

39 (12.66)

19

(6.17)

 

Tertiary education

30 (9.74)

18

(5.84)

Employment

Non employed

120 (38.96)

97

(31.49)

 

Employed

188 (61.04)

211(68.51)

Place of residence

Rural

112(36.36)

102(33.22)

Urban

196(63.64)

205(66.78)

 

Anemia

Censored

234 (75.97)

181(58.77)

 

Anemia

74(24.03)

127(41.23)

Opportunistic

No

151(49.03)

91(29.55)

infection

Yes

157(50.97)

217(70.45)

 

Tuberculosis

No

237(76.95)

213(69.16)

infection

Yes

71(23.05)

95(30.84)

 

Age

Age range

16 – 68 years

17

– 71 years

Baseline CD4

count

Count range

85 – 340 cells/mm3

50

– 295 cells/mm3

 

 

 

 

 

 

 

 

 

Table1 Baseline Socio-demographic and clinical characteristics of patients who were taking ART in St. Paul's and ALERT hospital during January 2008 – December 2012 (n=616)

Variables

 

Non Zidovudine

Zidovudine

 

 

(N=308)

(N=308)

 

 

[n (%)]

[n (%)]

 

 

 

 

Oral or vaginal

Candidiasis

No

258(83.77)

223(72.40)

Yes

50(16.23)

85(27.60)

 

Chronic

Diarrhea

No

274(88.96)

249(80.84)

Yes

34(11.04)

59(19.16)

 

Tuberculosis

treatment

No

246(79.87)

213(69.16)

Yes

62(20.13)

95(30.84)

 

Baseline

Weight

Greater than or equal to 60

60(19.48)

57(18.51)

Kg

 

 

 

Less than 60 Kg

248(80.52)

251 (81.49)

Baseline

functional

status

Working

53(17.21)

54 (17.53)

Ambulatory

233(75.65)

237 (76.95)

 

 

 

 

Bed ridden

22(7.14)

17 (5.52)

CD4 count

Greater than or equal to 200

51(67.86)

106 (68.51)

 

cells

 

 

 

Less than 200 cells

257(32.14)

202 (31.49)

Baseline ALT

Normal

281(91.23)

238 (77.27)

 

Abnormal

27(8.77)

70 (22.73)

Baseline AST

Normal

208(67.53)

197 (63.96)

 

Abnormal

100(32.47)

111 (36.04)

Table2 Baseline clinical and laboratory characteristics of patients who were taking ART in St. Paul's and ALERT hospital during January 2008 – December 2012 (n=616)

Variables

 

UHR [95% CI]

P-value

AHR [95% CI]

P-value

 

 

 

 

 

 

Sex

Male

1.00

 

 

 

 

Female

1.44 [1.0663- 1.9482]

0.002

--

 

Age

 

1.014 [1.0006 - 1.0267]

0.004

1.017 [1.0041 - 1.0307]

0.011

Oral or

No

1.00

 

 

 

vaginal

Candidiasis

Yes

1.74 [1.2969 - 2.3235]

0.001

--

--

 

 

 

 

 

Chronic

No

1.00

 

1.00

 

Diarrhea

Yes

2.08 [1.5167 - 2.8659]

0.001

1.85 [1.3439 - 2.5695]

0.001

 

Baseline

ART

Non ZDV regimen

1.00

 

1.00

 

ZDV regimen

1.71 [1.2838 - 2.2776]

0.001

2.84 [1.5224 - 5.3137]

0.001

regimen

 

 

 

 

 

Baseline

functional

status

 

Working

1.00

--

1.00

--

Ambulatory

0.71 [0.5038 - 0.9973]

0.048

0.67 [0.4783 - 0.9597]

0.028

         

Bed ridden

0.57 [0.2931 - 1.1068]

0.097

0.47 [0.2407 - 0.9228]

0.028

Baseline

WHO

staging

Stage I

1.00

--

 

 

Stage II

0.98 [0.6443 - 1.4762]

0.906

 

 

 

 

 

 

 

 

 

 

Stage III

1.95 [1.1926 - 3.2068]

0.008

--

--

 

Stage IV

1.65 [0.9608 - 2.8337]

0.007

 

 

Baseline

>= 200 cell

1.00

 

1.00

 

CD4 count

 

 

0.001

 

0.001

 

 

 

 

 

< 200 cells

5.91 [4.3346 - 8.0501]

 

4.96 [3.4144 - 7.2049]

 

 

 

 

 

 

 

Table3 Shows the unadjusted and adjusted hazard ratios of socio demographic, clinical and laboratory variables