(A) All survivors with PM; (B) Survivors with solid PM; (C) Survivors with germ cell tumors as PM; (D) Survivors with hematologic PM; (E) Survivors with acute lymphoblastic leukemia as PM. 1F/U: follow-up; 2NA: No case of SPM was observed due to limited number of PM cases.
Figure 1: Forest plot of the SIR of all SPM in survivors of various PM by age at diagnosis and follow-up time

(A) OS of all SPM in CACS; (B) OS of solid SPM in CACS; (C) OS of hematologic SPM in CACS. *For hematologic SPM, cases diagnosed at 21-30 and 30+ years of follow-up were pooled together due to the limited number of cases
Figure 2: OS of SPM in CACS diagnosed at different periods of follow-up.

(A) 1-10 years; (B) 11-20 years; (C) 21-30 years; (D) 30+ years
Figure 3: Wind rose diagrams of the top 15 SPM in CACS at different periods of follow-up.

Figure 4: Risk factors of SPM in CACS at different periods of follow-up

(A) Solid tumors as SPM in survivors of all types of PM; (B) Testicular cancer as SPM in survivors of all types of PM; (C) Breast cancer as SPM in survivors of all types of PM; (D) Soft tissue cancer as SPM in survivors of all types of PM; (E) Hematologic malignancy as SPM in survivors of all types of PM; (F) Leukemia as SPM in survivors of all types of PM. 1F/U: follow-up; 2NA: No case of SPM was observed due to limited number of PM cases.
Figure 5: Forest plot of SIR of selected SPM in survivors of all PM by age at diagnosis and follow-up time.