Figure 1: Inclusion and exclusion diagram
Characteristics |
NCGC |
CGC |
P |
Sex |
|
|
<0.001 |
Female |
2217 (45.1%) |
492 (20.8%) |
|
Male |
2695 (54.9%) |
1874 (79.2%) |
|
Age (y) |
|
|
<0.001 |
<60 |
1589 (32.3%) |
970 (41.0%) |
|
61-74 |
1806 (36.8%) |
972 (41.1%) |
|
>75 |
1517 (30.9%) |
424 (17.9%) |
|
Marital status |
|
|
<0.001 |
Married |
2972 (60.5%) |
1679 (71.0%) |
|
Unmarried * |
1809 (36.8%) |
641 (27.1%) |
|
Unknown |
131 (2.7%) |
46 (1.9%) |
|
Race |
|
|
<0.001 |
White |
2751 (56.0%) |
2086 (88.2%) |
|
African-American |
761 (15.5%) |
94 (4.0%) |
|
Other |
1400 (28.5%) |
186 (7.9%) |
|
Year of diagnosis |
|
|
0.241 |
2004-2006 |
2066 (42.1%) |
949 (40.1%) |
|
2007-2008 |
1417 (28.8%) |
719 (30.4%) |
|
2009-2010 |
1429 (29.1%) |
698 (29.5%) |
|
Grade |
|
|
<0.001 |
Well/moderate |
1343 (27.3%) |
869 (36.7%) |
|
Poor/undifferentiated |
3390 (69.0%) |
1381 (58.4%) |
|
Unknown |
179 (3.6%) |
116 (4.9%) |
|
Surgery |
|
|
<0.001 |
Gastrectomy (partial, subtotal, |
3093 (63.0%) |
360 (15.2%) |
|
hemi-) |
|
|
|
Near-total or total gastrectomy |
737 (15.0%) |
199 (8.4%) |
|
Gastrectomy with the removal of a |
534 (10.9%) |
1493 (63.1%) |
|
portion of the esophagus |
|
|
|
Gastrectomy with en bloc |
538 (11.0%) |
286 (12.1%) |
|
resection of other organs |
|
|
|
Gastrectomy or surgery |
10 (0.2%) |
28 (1.2%) |
|
T stage |
|
|
<0.001 |
T1 |
1125 (22.9%) |
481 (20.3%) |
|
T2 |
620 (12.6%) |
262 (11.1%) |
|
T3 |
1706 (34.7%) |
942 (39.8%) |
|
T4a |
1087 (22.1%) |
549 (23.2%) |
|
T4b |
374 (7.6%) |
132 (5.6%) |
|
N stage |
|
|
<0.001 |
N0 |
1991 (40.5%) |
797 (33.7%) |
|
N1 |
1765 (35.9%) |
1139 (48.1%) |
|
N2 |
860 (17.5%) |
321 (13.6%) |
|
N3 |
296 (6.0%) |
109 (4.6%) |
|
Stage |
|
|
<0.001 |
IA/IB |
1443 (29.4%) |
587 (24.8%) |
|
IIA/IIB |
1693 (34.5%) |
969 (41.0%) |
|
IIIA/IIIB/IIIC |
1776 (36.2%) |
810 (34.2%) |
|
Table 1: Comparison of clinicopathologic characteristics between patients with CGC and NCGC
Characteristics n |
5-year CSS |
P |
HR |
95% CI |
P |
|
Sex |
|
|
0.985 |
NI |
|
|
Male |
4569 |
45% |
|
|
|
|
Female |
2709 |
46% |
|
|
|
|
Age (years) |
|
|
<0.001 |
|
|
|
<60 |
2559 |
51% |
|
Reference |
|
|
61-74 |
2778 |
47% |
|
1.372 |
1.7271-1.481 |
<0.001 |
>75 |
1941 |
34% |
|
2.227 |
2.053-2.415 |
<0.001 |
Marital status |
|
|
<0.001 |
|
|
|
Married |
4651 |
48% |
|
Reference |
|
|
Unmarried* |
2450 |
40% |
|
1.158 |
1.082-1.238 |
<0.001 |
Unknown |
177 |
49% |
|
0.983 |
0.794-1.216 |
0.837 |
Race |
|
|
<0.001 |
|
|
|
White |
4837 |
42% |
|
Reference |
|
|
African-American |
855 |
44% |
|
1.026 |
0.928-1.135 |
0.618 |
Other |
1586 |
56% |
|
0.755 |
0.693-0.823 |
<0.001 |
Year of diagnosis |
|
|
<0.001 |
|
|
|
2004-2006 |
3015 |
41% |
|
Reference |
|
|
2007-2008 |
2136 |
45% |
|
0.922 |
0.856-0.992 |
0.030 |
2009-2010 |
2127 |
53% |
|
0.773 |
0.714-0.837 |
<0.001 |
Tumor location |
|
|
<0.001 |
|
|
|
Non-cardia |
4912 |
48% |
|
Reference |
|
|
Cardia |
2366 |
39% |
|
1.303 |
1.216-1.397 |
<0.001 |
Grade |
|
|
<0.001 |
|
|
|
Well/moderate |
2212 |
55% |
|
Reference |
|
|
Poor/undifferentiated |
4771 |
40% |
|
1.328 |
1.234-1.430 |
<0.001 |
Unknown |
295 |
58% |
|
1.058 |
0.879-1.275 |
0.550 |
Surgery |
|
|
<0.001 |
|
|
|
Gastrectomy (partial, subtotal, hemi-) |
3453 |
50% |
|
Reference |
|
|
Near-total or total gastrectomy |
936 |
44% |
|
1.012 |
0.642-1.595 |
0.960 |
CSS: cancer-specific survival; HR: hazard ratio; NI, not included; CI: confidence interval
*Including single (never married), widowed, separated, and divorce.
#Continuous variable. Bold: P<0.05.
Table 2: Prognostic factors for cause-specific survival in GC patients
Gastrectomy with the removal of a portion of the esophagus |
|
|
|
2027 |
40% |
|
1.208 |
0.762-1.914 |
0.421 |
||
Gastrectomy WITH en bloc |
resection |
of |
other |
824 |
40% |
|
1.183 |
0.752-1.863 |
0.467 |
||
organs |
|
|
|
|
|
|
|
|
|
||
Gastrectomy or surgery |
|
|
|
38 |
49% |
|
1.170 |
0.738-1.854 |
0.504 |
||
Lymph nodes examined# |
|
|
|
|
|
|
0.987 |
0.984-0.990 |
<0.001 |
||
T stage |
|
|
|
|
|
<0.001 |
NI |
|
|
||
T1 |
|
|
|
1606 |
79% |
|
|
|
|
||
T2 |
|
|
|
882 |
63% |
|
|
|
|
||
T3 |
|
|
|
2648 |
36% |
|
|
|
|
||
T4a |
|
|
|
1636 |
24% |
|
|
|
|
||
T4b |
|
|
|
506 |
20% |
|
|
|
|
||
N stage |
|
|
|
|
|
<0.001 |
NI |
|
|
||
N0 |
|
|
|
2788 |
70% |
|
|
|
|
||
N1 |
|
|
|
2904 |
37% |
|
|
|
|
||
N2 |
|
|
|
1181 |
19% |
|
|
|
|
||
N3 |
405 |
9% |
|
|
|
||||||
Stage |
|
|
<0.001 |
|
|||||||
IA/IB |
2030 |
79% |
|
Reference |
|||||||
IIA/IIB |
2662 |
44% |
|
3.131 |
2.813-3.485 |
<0.001 |
|||||
IIIA/IIIB/IIIC |
2586 |
20% |
|
6.476 |
5.826-7.197 |
<0.001 |
PSM: propensity score matching; CSS, cancer-specific survival; CI, confidence interval; HR, hazard ratio.
* Adjusted for age, LN examined, surgery, marital status, year of diagnosis, grade.
# Adjusted for age, LN examined, surgery, marital status, year of diagnosis, grade, and radiation.
Table 3: Prognostic value of tumor site on cause-specific survival of GC patients by TNM stage
Figure 1: Inclusion and exclusion diagram
Overall survival in (A) the unmatched, (B) the propensity score-matched, and (C) the inverse probability of treatment weight-adjusted analysis in cardia adenocarcinoma patients and non-cardia GC patients after surgery
Figure 2: Overall survival of cardia adenocarcinoma and non-cardia GC patients
Tables at a glance
Figures at a glance