
Compounds	*S. aureus*	*B. substills*	*E. coli*	*C. albicans*	*A. niger*
3a	+	+++	+	++	++
3b	++	++	+++	+++	++
3c	+	++	+++	++	++
3d	_	+++	+	+++	+++
3e	+++	++	++	+++	++
3f	++	+++	_	++	++
3g	+++	_	+	_	+++
3h	++	+	+++	++	_
3i	_	+++	+	+++	+++
3j	_	+++	+	+++	+++
3k	+++	++	++	+++	++
3l	++	+++	_	++	++
3m	+++	_	+	_	+++
3n	++	+	+++	++	_
3o	_	+++	+	+++	+++

SM (streptomycin) and G F (Griseofulvin). The inhibition diameter in Mm (-) < 6, (+) 7-9, (++) 10-15, (+++) 16-22, (++++) 23-28
Table 1: Antibacterial and Antifungal activities of compounds 3a-o


compounds	IR(KBr)	H1NMR (300MHz DMSO)	C13NMR (300MHz, DMSO-d6)
3a	2945 (C-H Aromatic stretch) 1791.8, 1713, 1641, 1520, 779 (C-S)	9.53 (S1H NH)	14.2,13.1,13.6,23.0,37.9,38.2, 34.5,39.4,40.0,58.5,76.8,7.3,111. 8,159.1,126.2,137.3,160.2,162.1.
3b	2945 (C-H Aromatic stretch),3275(OH of phenyl ring) 1639 & 1655 cyclic carbonyl ring,690 (C-S-C linkage of thiazolidinone ring),1152 (c-o str)3209 (N-H Stretch) 1791.8,1713,1641,1520,779(C-S);	2.24,4.23,3.56 6.8-7.8 (M.8H Aromatic proton) 3.5 (s,2H,CH2 Thiazolidine ring)	14.1,13.0,13.62,23.1,37.9,38. 0,34.1,39.2,40.1,58.3,72.3,7.3, 111.5,159.1,126.0, 137.1,160.2,162.1.
3c	2945 (C-H Aromatic stretch) 3272(OH of phenyl ring) 1637 & 1653 cyclic carbonyl ring,693(C-S-C linkage of thiazolidinone ring),1151 (c-o str)3208 (N-H Stretch) 1791.8,1713,1641,1520,779 (C-S);	2.24,4.21,3.54 6.8-7.8(M.8H Aromatic proton)3.4(s,2H,CH2 Thiazolidine ring	14.2,13.1,13.2,23.0,37.8,38.1, 34.2,39.4,40.1, 58.5,76.5,7.3,111.3,159.2,126.1, 137.32,160.2,162.2.
3d	2945 (C-H Aromatic stretch) 3274(OH of phenyl ring) 1638 & 1650 cyclic carbonyl ring,691(C-S-C linkage of thiazolidinone ring),1150 (c-o str) 3207(N-H Stretch) 1791.8,1713,1641,1520,779(C-S)	2.25,4.20,3.52 6.8-7.8(M.8H Aromatic proton)3.3(s,2H,CH2 Thiazolidine ring)	14.2,13.1,13.6,23.0,37.9,38.2, 34.5,39.4,40.0,58.5,76.8,7.3,111.8, 159.1,126.2,137.3,160.2,162.1.
3e	2945 (C-H Aromatic stretch)1791.8, 1713, 1641, 1520, 779(C-S)	2.22,4.20,3.51 6.8-7.8(M.8H Aromatic proton)3.3(s, 2H,CH2 Thiazolidine ring)	14.2, 13.1, 13.2, 23.1, 37.9, 38.1, 34.2, 39.4, 40.0, 58.1, 76.8, 7.3, 111.2, 159.0, 126.1, 137.3, 160.1, 162.1.
3f	2945 (C-H Aromatic stretch)1791.8, 1713, 1641, 1520, 779 (C-S)	2.20,4.21,3.54m, 6.8-7.8(M.8H Aromatic proton) 3.3( s, 2H, CH2 Thiazolidine ring)	14.1, 13.2, 13.0, 23.0, 37.9, 38.1, 34.5, 39.2, 40.0, 58.2, 76.8, 7.3, 111.2, 159.1, 126.2, 137.3, 160.2, 162.1.
3g	2942 (C-H Aromatic stretch) 1791.8, 1713, 1641, 1520, 779 (C-S)	2.24,4.23,3.56 6.8-7.8 (M.8H Aromatic proton)3.4 (s,2H,CH2 Thiazolidine ring)	14.0,13.1,13.6,23.1,37.9,38.0, 34.5, 39.4, 40.0, 58.2,76.2,7.3,111.3,159.1,126.1, 137.2,160.2,162.1.
3h	2944 (C-H Aromatic stretch) 1791.8,1713,1641,1520,779(C-S); 1689(C= O) of thiazolidinone ring	2.24, 4.23, 3.56 6.5-7.8 (M.8H Aromatic proton) 3.3 ( s, 2H, CH2 Thiazolidine ring)	14.0,13.213.6,23.0,37.9,38.2, 34.2,39.1,40.0,58.51,76.2,7.,111.3, 159.1,126.2,137.3,160.2,162.1.
3i	2941 (C-H Aromatic stretch) 1791.8, 1713, 1641, 1520, 779 (C-S);	2.24, 4.23, 3.56, 6.7-7.8 (M.8H Aromatic proton) 3.3 (s, 2H, CH2 Thiazolidine ring)	14.2,13.1, 13.5, 23.1, 37.9, 38. 2, 34.5, 39.4, 40.1,58.5,76.8,7.3,111.8,159.1, 126.2,137.3,160.2,162.1.
3j	2945 (C-H Aromatic stretch),3275(OH of phenyl ring) 1639 & 1655 cyclic carbonyl ring,690 (C-S-C linkage of thiazolidinone ring),1152 (c-o str)3209 (N-H Stretch) 1791.8,1713,1641,1520,779(C-S);	2.24,4.23,3.56 6.8-7.8 (M.8H Aromatic proton) 3.5 (s,2H,CH2 Thiazolidine ring)	14.1,13.0,13.62,23.1,37.9,38.0, 34.1,39.2,40.1,58.3,72.3,7.3,111.5, 159.1,126.0,137.1,160.2,162.1.
3k	2945 (C-H Aromatic stretch) 3272(OH of phenyl ring) 1637 & 1653 cyclic carbonyl ring,693(C-S-C linkage of thiazolidinone ring),1151 (c-o str)3208 (N-H Stretch) 1791.8,1713,1641,1520,779(C-S)	2.24,4.21,3.54 6.8-7.8(M.8H Aromatic proton)3.4(s,2H,CH2 Thiazolidine ring	14.2,13.1,13.2,23.0,37.8,38.1,34.2, 39.4,40.1,58.5,76.5,7.3,111.3, 159.2,126.1,137.32,160.2,162.2.
3l	2945 (C-H Aromatic stretch) 3274(OH of phenyl ring) 1638 & 1650 cyclic carbonyl ring,691(C-S-C linkage of thiazolidinone ring),1150 (c-o str) 3207(N-H Stretch) 1791.8,1713,1641,1520,779(C-S)	2.25,4.20,3.52 6.8-7.8(M.8H Aromatic proton)3.3(s,2H,CH2 Thiazolidine ring)	14.2,13.1,13.6,23.0,37.9,38.2, 34.5,39.4,40.0,58.5, 76.8,7.3,111.8,159.1,126.2, 137.3,160.2,162.1
3m	2945 (C-H Aromatic stretch)1791.8, 1713, 1641, 1520, 779(C-S)	2.22,4.20,3.51 6.8-7.8(M.8H Aromatic proton)3.3(s, 2H,CH2 Thiazolidine ring)	14.2, 13.1, 13.2, 23.1, 37.9, 38.1, 34.2, 39.4, 40.0, 58.1, 76.8, 7.3, 111.2, 159.0, 126.1, 137.3, 160.1, 162.1
3n	2945 (C-H Aromatic stretch)1791.8, 1713, 1641, 1520, 779 (C-S)	2.20,4.21,3.54m, 6.8-7.8(M.8H Aromatic proton) 3.3( s, 2H, CH2 Thiazolidine ring)	14.1, 13.2, 13.0, 23.0, 37.9, 38.1, 34.5, 39.2, 40.0, 58.2, 76.8, 7.3, 111.2, 159.1, 126.2, 137.3, 160.2, 162.1
3o	2942 (C-H Aromatic stretch) 1791.8, 1713, 1641, 1520, 779 (C-S)	2.24,4.23,3.56 6.8-7.8 (M.8H Aromatic proton)3.4 (s,2H,CH2 Thiazolidine ring)	14.0,13.1,13.6,23.1,37.9,38.0, 34.5, 39.4, 40.0, 58.2,76.2,7.3,111.3,159.1,126.1, 137.2,160.2,162.1

Table 3: IR, H1NMR & C13NMR of newly synthesized 3(a-o)


Comp	R*	Mol. Formula	Mol. Wt (gm)	M.Pt (C0)	RF Value	% Yield	Analysis found (Cal) % C H N
3a	H	C18H 14 O2 N 2S	322	165	0.91	83	67.08 67.0	4.34 4.33	8.69 8.11
3b	2-OH	C17H16 O2N 2S	338	172	0.72	79	63.90 63.2	4.14 4.74	7.62 7.43
3c	3-OH	C17H16 O2N 2S	338	181	0.75	75	63.90 63.2	4.14 4.74	7.62 7.43
3d	4-OH	C17H16 O2N 2S	338	188	0.82	58	63.90 63.2	4.14 4.74	7.62 7.43
3e	2-NO2	C18H 13O4N3S	367	191	0.77	54	58.85 58.84	3.54 3.41	11.4 11.0
3f	3-NO2	C18H 13O4N3S	367	191	0.77	54	58.85 58.84	3.54 3.41	11.4 11.0
3g	4-NO2	C18H 13O4N3S	367	191	0.77	54	58.85 58.84	3.54 3.41	11.4 11.0
3h	2-CL	C18H13O2N2SCI	356	161	0.75	56	60.67 60.2	3.65 3.62	7.86 7.54
3i	4-CL	C18H13O2N2SCI	356	161	0.75	56	60.67 60.2	3.65 3.62	7.86 7.54
3j	3-OCH3	C19H16O3N2S	352	144	0.66	66	64.77 64.2	4.54 4.20	7.9 7.54
3k	4-OCH3	C19H16O3N2S	352	144	0.66	66	64.77 64.2	4.54 4.20	7.9 7.54
3l	3-(OCH3)3	C21H20O3N2S	380	138	0.73	68	66.31 66.0	5.26 5.20	7.36 7.33
3m	-N(CH3)2	C20H19O2N3S	365	172	0.77	62	65.75 56.03	5.20 5.20	11.5 11. 4
3n	2-Br	C18H13O2N2SBr	391	163	0.73	59	55.24 55.22	3.32 3.20	7.16 7.54
3o	4-Br	C18H13O2N2SBr	391	163	0.73	59	55.24 55.22	3.32 3.20	7.16 7.54


	Surface Dot 3-D structure	Binding Energy In Kcal/mole	H-bond distance	Amino acids
1*		-11.6863	2.744652	955-DEF 145-ASP 955- DEF 82-PHE 80-PHE 33-LYS
2		-10.7636		958- DEF
3		-10.0056	2.452949 2.900864	145 -ASP
4		-10.0197	2.633822 2.936493 2.482387 2.62280 2.478299	83-LEU
5		-10.0197	2.895364	145- ASP
6		-10.3206	2.907496 2.552889	125 -HIS 145- ASP
7		-9.84859	2.555301, 2.892527, 2.900609A	14 -THR 127 -ASP
8*		-11.0653	2.980913A 2.22294A 2.735119A 2.857214, 2.5155 A	85-GLN,85-LEU
9
10		-9.62396	2.59475, 2.593906, 2.882631, 2.493378.	83-LEU
11		-9.62396	2.59475, 2.593906, 2.882631, 2.493378.	83-LEU
12		-10.7636	---
13		-9.68543	----
14		-10.5341	2.840492 2.412427
15		-10.475	1.064365 2.474559 2.296541 1.952081 1.935802 1.758240	145- ASP 80 -PHE 15 -TYR 15- TYR 33- LYS 147 -ASP

Tables at a glance

Figures at a glance