Figure 1 Figure 1: Scatter plots with least square fit for the disease group

Figure 1a: Scatter plot showing a positive correlation between PBAC and left eye PSD (p=0.009)
Figure 1b: Scatter plot showing a negative correlation between PBAC and left eye MD (p=0.003)
Figure 1c: Scatter plot showing negative correlation between PBAC and left eye VFI (p=0.010)
Figure 1d: Scatter plot showing a negative correlation between PBAC and left eye average NFL thickness (p=0.11)

Figure 2 Figure 2 Scatter plots with least square fit for all subjects

Figure 2a: Scatter plot showing a positive correlation between PBAC and left eye PSD (p<0.0001)
Figure 2b: Scatter plot showing a negative correlation between PBAC and left eye MD (p=0.002)
Figure 2c: Scatter plot showing negative correlation between PBAC and left eye VFI (p=0.003)
Figure 2d: Scatter plot showing a negative correlation between PBAC and left eye average NFL thickness (p=0.266)

 

Disease group
(n=25)

Control group (n=23)

p value

Mean age

45 +/- 7

48 +/- 6

0.1

Family history of glaucoma

2

4

0.33#

Gonioscopy

Open

Open

 

Spherical equivalent (dioptre)

-1.7 +/- 1.7

-1.9 +/- 2.7

0.8

Central corneal thickness (um)

548 +/- 26

548 +/- 26

0.9

IOP (mmHg)

15 +/- 3

14 +/- 2

0.4

CDR

0.3

0.3

1.0

PBAC

1815 +/- 1944

35.3 +/- 49.6

<0.0001

Menorrhagia duration (years)

2.6

NA

 

Ferritin (ng/mL)

44.05 +/- 48.3 (n=23)

NA

 

Pre-transfusion Hb (g/dl)

8.04 +/- 1.97 (n=23)

NA

 

Table1 Table showing baseline data for study subjects

 

Disease group (n=25)

Control group
(n=23)

p value

PSD

2.73 +/- 1.9

1.82 +/- 0.42

<0.01

MD

-3.0 +/- 3.3

-2.28 +/- 1.26

0.35

VFI

95.64 +/- 7.5

97.4 +/- 1.9

0.34

NFL

105.6 +/- 11.4

103.8 +/- 10.0

0.57

Table2 Table comparing the mean visual field global indices and average NFL thickness in the disease group and control group

 

All subjects
(n = 48)

Disease group
(n= 25)

Control group (n= 23)

PSD against PBAC
Correlation coefficient
(p value)

0.63
(<0.0001)

0.60
(0.009)

-0.28
(0.22)

MD against PBAC
Correlation coefficient
(p value)

-0.61
(0.001)

-0.68
(0.003)

0.46
(0.04)

VFI against PBAC
Correlation coefficient
(p value)

-0.61
(0.003)

-0.65
(0.009)

0.22
(0.35)

NFL against PBAC
Correlation coefficient
(p value)

-0.17
(0.27)

-0.33
(0.11)

0.02
(0.93)

Table3 Table tabulating the correlation coefficient calculated using Pearson’s correlation analysis

 

Normal menses (n=9)

Menopause
(n=14)

p value

PSD

1.66 +/- 0.44

1.95 +/- 0.38

0.15

MD

-1.66 +/- 1.33

-2.79 +/- 0.97

0.06

VFI

97.8 +/- 1.8

97.1 +/- 2.0

0.45

NFL

104.8 +/- 10.5

103.2 +/- 10.1

0.72

Table4 Table comparing the mean VF indices and NFL thickness between subjects with normal menses and subjects with menopause

 

All subjects
(n = 34)

Control group
(n= 9)

PSD against PBAC
Correlation coefficient
(p value)

0.63 (<0.003)

0.09 (0.83)

MD against PBAC
Correlation coefficient
(p value)

-0.67 (0.001)

0.14 (0.72)

VFI against PBAC
Correlation coefficient
(p value)

-0.64 (0.003)

0.21 (0.59)

NFL against PBAC
Correlation coefficient
(p value)

-0.25 (0.16)

-0.2 (0.6)

Table5 Table tabulating the correlation coefficient calculated using Pearson’s correlation analysis, with menopause subjects excluded