Figure 1: The fundus structure change of a patient had PIC without CNV. (a) Multicolor fundus photo showed local edema with sporadic, small, round, yellow-white lesions limited to the posterior pole of right eye and revealed no hemorrhage. (b) SD-OCT showed the presence of focal elevations of the EZ band with underlying hyper-reflective material. RPE and BM were integral and neither choroidal hyper-transmission nor hypo-transmission was observed below the lesion. (c) OCTA showed no sign of CNV development. (d) Just two weeks later, the edema absorbed. (e) SD-OCT showed hyper-reflective material under EZ shrunk and choroid maintained normal transmission. (f) OCTA was no sign of CNV development during two weeks follow-up.

Figure 2: The funds structure of a patient had PIC without CNV at baseline and developed secondary CNV during follow-up. (a) At first visit, fundus photography showed a distributed yellow-white lesion in her macular region. (b) SD-OCT imaging revealed a disruption of the EZ zone, minimal sub-retinal fluid with a slight elevation of RPE, and normal choroidal transmission. (c) Two weeks later, SD-OCT imaging showed a small round lesion appeared in the inferior nasal of fovea (red arrowheads), and a moderate reflective material under RPE with a disruption of BM, hyper-transmission could be found in choroid (white arrowheads). (d) Meanwhile, the 3×3 mm SD-OCTA en face image showed an abnormal vascular network. (e) As the disease progressed, SD-OCT images began to show an area of choroidal hypo-transmission adjacent to the areas of a choroidal hyper-transmission (yellow arrowheads).(f, g, h) The vascular network grown larger and lesion extended, because the patient refused anti-VEGF treatment.

Figure 3: The choroidal neovascularization before and after treatment. (a, b) Before treatment, OCTA show vascular network. (c, d) After anti-VEGF treatment, the neovascularization shrinkaged after treatment.