Figure 1 Effect of GLM extract on hot plate test (i.e. Paw withdrawal threshold). Data are expressed as mean ± SEM, n = 6 rats per group. ap < 0.01 versus normal control group; bp < 0.01 versus VC group; cp > 0.05 non significant versus normal control group.

Figure 2 Effect of GLM extract on acetone drop test (i.e. Paw reflex threshold). Data are expressed as mean ± SEM, n = 6 rats per group. ap < 0.01 versus normal control group; bp < 0.01 versus VC group; cp > 0.05 non significant versus normal control group.

Figure 3 Effect of GLM extract on paw pressure test (i.e. Paw withdrawal threshold). Data are expressed as mean ± SEM, n = 6 rats per group. ap < 0.01 versus normal control group; bp < 0.01 versus VC group; cp > 0.05 non significant versus normal control group.

Figure 4 Effect of GLM extract on Von Frey hair test (i.e. Paw withdrawal threshold). Data are expressed as mean ± SEM, n = 6 rats per group. ap < 0.01 versus normal control group; bp < 0.01 versus VC control group; cp > 0.05 non significant versus normal control group.

Figure 5 Effect of GLM extract on Tail immersion test (Tail withdrawal threshold). Data are expressed as mean ± SEM, n = 6 rats per group. ap < 0.01 versus normal control group; bp < 0.01 versus VC group; c,dp > 0.05 non significant versus normal control group & VC group.

Figure 6 Effect of GLM extract on muscle grip strength (i.e. Fall off time). Data are expressed as mean ± SEM, n = 6 rats per group. ap < 0.01 versus normal control group; bp < 0.01 versus VC group; cp > 0.05 non significant versus normal control group.

Groups

TBARS (nmols MDA/mg of protein)

GSH
(mg/mg of protein)

CAT
(Units/mg of protein)

Total calcium
(ppm/mg of protein)

Normal control group

5.97 ± 0.26

73.25 ± 2.14

0.194 ± 0.002

2.98± 0.25

Vincristine group

8.28 ± 0.24a

45.93 ± 2.92a

0.111 ± 0.003a

22.72 ± 0.41a

  GLM extract (50 mg/kg; p.o.) + Vincristine group

6.86 ± 0.16b

54.91 ± 1.48b

0.156 ± 0.007b

11.64± 0.27b

GLM extract (100 mg/kg; p.o.) + Vincristine group

6.58 ± 0.14b

64.85 ± 1.78b

0.178 ± 0.008b

8.06 ±0.38b

Gabapentin+  Vincristine   group

6.46 ± 0.19b

65.93 ± 1.76b

0.187 ± 0.015b

7.26± 0.42b

Per se ( GLM, 100 mg/kg; p.o.) group

6.01 ± 0.28c

73.48 ±1.45c

0.183 ± 0.009c

3.05 ± 0.54c

Table 1: Data were expressed as mean ± S.E.M., n = 6 rats per group ap < 0.01 versus normal control group, bp < 0.01 versus Vincristine control group. cp> 0.05 non-significant versus normal control group.