Tables at a glance

Table 1

Figures at a glance

Figure 1

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Figure 14

Table 1

Table 1: Comparison of the similarities and differences of tandem-mass spectra of PSMA-617 and Imp. 2.

FIGURE 1

Figure 1: The synthetic scheme of PSMA-617 and drug of 175/177Lu-PSMA-617 [8].

FIGURE 2

Figure 2: Tandem-mass spectra at m/z of (a) 1042 and (b) 522. (c) The fragmentation pathways of PSMA-617.

FIGURE 3

Figure 3: Tandem-mass spectra at m/z of (a) 1215 and (b) 608. (c) The fragmentation pathways of Lu-PSMA-617.

FIGURE 4

Figure 4: Chromatograms of (a) purchased PSMA-617 reference standard, (b) homemade PSMA-617 product, and (c) Lu-PSMA-617.

FIGURE 5

Figure 5: (a) Molecular and fragmented ion mass spectra of impurity 1 at retention time tR of 5.83 min and (b) molecular fragmentation pathway.

FIGURE 6

Figure 6: Tandem-mass spectra of m/z = 1057 for Impurity 2 at retention time tR of 6.35 min in PSMA-617.

FIGURE 7

Figure 7: Supposed identity of Imp. 2 and its fragmented structures in synthetic PSMA-617 product.

FIGURE 8

Figure 8: Fragmented ion mass spectra at m/z = 307 and supposed metabolite identity by rat liver microsomes.

FIGURE 9

Figure 9: Fragmented ion mass spectra at m/z = 365 and supposed metabolite identity by rat liver microsomes

FIGURE 10

Figure 10: Fragmented ion mass spectra at m/z = 432 and supposed metabolite identity.

FIGURE 11

Figure 11: Fragmented ion mass spectra at m/z = 896 and supposed metabolite identity.

FIGURE 12

Figure 12: Fragmented ion mass spectra at m/z = 495 and supposed metabolite identity by rat kidney homogenate.

FIGURE 13

Figure 13: Fragmented ion mass spectra at m/z = 697 and supposed metabolite identity by rat kidney homogenate.

FIGURE 14

Figure 14: Metabolism study for Lu-PSMA-617 by rat liver microsomes and kidney homogenate.